According to the analysis of related databases, 3034-62-6, the application of this compound in the production field has become more and more popular.
Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3034-62-6, name is 2-Iodo-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C3H3IN2
To a stirred solution of 2-iodo-1H-imidazole (174 mg, 896 pmol) and cyclopropyl{4-[(2-{[6- (4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yI)-1 H-benzimidazol-2-yI]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone (150 mg, 299 jjmol) in dioxane (2.0 mL) and water (0.5 mL) was added sodium carbonate (130 mg, 1.22 mmol) and Pd(dppf)C12 . CHCI (48.8 mg, 59.7 pmol) and Tetrakis(triphenylphosphin)palladium (69.0 mg, 59.7 ljmol). The mixture washeated to reflux for 36 h. Further 2-iodo-1H-imidazole (174 mg, 896 pmol) Pd(dppf)C12. CH2CI2 (48.8 mg, 59.7 jjmol) and Tetrakis(triphenylphosphin)palladium (69.0 mg, 59.7 pmol). were added and the mixture was heated to reflux for 7 h. Methanol was added, the mixture was filtered and the solvent was removed in vacuum. Silicagel chromatography gave a solid that was crystallized from ethanol to give 20.0 mg (14 % yield) of the title compound.LC-MS (Method 5): R1 = 2.17 mm; MS (ESIpos): m/z = 443 [M+H]1H-NMR (400 MHz, DMSO-d6) [ppm]: 2.490 (1.57), 2.495 (3.44), 2.500 (4.85), 2.505 (3.44),2.509 (1.55), 3.303 (16.00).
According to the analysis of related databases, 3034-62-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; SCHULZE, Volker; HEINRICH, Tobias; PRINZ, Florian; LEFRANC, Julien; SCHROeDER, Jens; MENGEL, Anne; BONE, Wilhelm; BALINT, Joszef; WENGNER, Antje; EIS, Knut; IRLBACHER, Horst; KOPPITZ, Marcus; BOeMER, Ulf; BADER, Benjamin; BRIEM, Hans; LIENAU, Philip; CHRIST, Clara; STOeCKIGT, Detlef; HILLIG, Roman; (1256 pag.)WO2017/102091; (2017); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem