Category: 3034-50-2

Electric Literature of 3034-50-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3034-50-2, name is Imidazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows.

To a mixture of acetophenone 7 (0.56g, 3.0mmol) and imidazole-4-carbaldehyde (0.29g, 3.0mmol) in ethanol (25mL) was added 10% sodium hydrate aqueous (5mL), the mixture was stirred for 24h at room temperature [17]. The solution was acidified with 1N HCl and filtered, and the filter cake was recrystallized from ethanol got 8 as white power (0.60g). Yield: 87.4%; mp: 185-186C; IR (KBr, cm-1) nu: 3443 (OH), 3063 (Ar-H), 1719 (C=O), 1617, 1571 (aromatic frame); 1H NMR (400MHz, DMSO-d6) delta: 11.44 (s, 1H, OH), 7.91 (s, 1H, imidazole-2-H), 7.79 (s, 1H, imidazole-5-H), 7.59 (d, J=8.4Hz, 1H, flavone-5-H), 6.85 (d, J=1.8Hz, 1H, flavone-3-H), 6.77-6.72 (m, 2H, flavone-6-H, flavone-8-H) ppm; 13C NMR (101MHz, DMSO-d6) delta: 181.2, 167.7, 166.9, 146.0, 138.0, 130.6, 126.0, 113.9, 113.3, 104.1, 99.0ppm; MS (m/z): 229 [M+H]+; HRMS (TOF) calcd for C12H8N2O3: [M+H]+, 229.0613; found, 229.0617.

The chemical industry reduces the impact on the environment during synthesis Imidazole-4-carbaldehyde. I believe this compound will play a more active role in future production and life.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3034-50-2, name is Imidazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: Imidazole-4-carbaldehyde

General procedure: To a mixture of 2-aminopyridines (1 mmol), aromatic aldehydes (1 mmol) and isocyanides in EtOH (or MeCN) was added beta-cyclodextrin-SO3H (10 mol%). The reaction mixture was then allowed to stir for 1 h under 80 C.After complication of this reaction, the resulting mixture was cooled and the beta-cyclodextrin-SO3H was removed by filtration, the organic phase was concentrated under reduced pressure. Afterwards the residue were washed with EtOAc and cyclohexane (1:3) and dried to give the product

According to the analysis of related databases, 3034-50-2, the application of this compound in the production field has become more and more popular.

Electric Literature of 3034-50-2, The chemical industry reduces the impact on the environment during synthesis 3034-50-2, name is Imidazole-4-carbaldehyde, I believe this compound will play a more active role in future production and life.

Example 10 : Ethyl 4-cyclohexyl-1-[(/?)-2-{3-[5-(1 H-imidazol-4-yl)pentyl]- ureido}-3-(4-methoxyphenyl)propionyl]piperidine-4-carboxylate10-1-1 1-Trityl- 1 H-imidazole-4-carbaldehyde:To a solution containing 1 g (10.4 mmol) of 1 H-imidazole-4-carbaldehyde and 3.18 g (11.4 mmol) of trityl chloride suspended in 28 ml of acetonitrile are added dropwise 2.5 ml (17.7 mmol) of triethylamine. After stirring for 2 hours at room temperature, 30 ml of water are added and the crude reaction product is filtered. 3.2 g in the form of a beige-coloured powder are obtained and used in the following step without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Imidazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Application of 3034-50-2,Some common heterocyclic compound, 3034-50-2, name is Imidazole-4-carbaldehyde, molecular formula is C4H4N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[1815] To a stirred solution of 4(5)-imidazolecarboxaldehyde (20.0 g, 0.208 mmol) in CH2Cl2 (200 mL), was added Et3N (29.0 mL, 0.208 mmol). The solution was then cooled down at 0 C., followed by addition of triphenylmethylchloride (52.8 g, 0.18 mmol) at 0 C. The resulting solution was stirred at room temperature overnight and then washed it with brine, water and concentrated to dryness to give a white solid (63.0 g, 98% yield, MH+=339.1)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Imidazole-4-carbaldehyde, its application will become more common.

Application of 3034-50-2, The chemical industry reduces the impact on the environment during synthesis 3034-50-2, name is Imidazole-4-carbaldehyde, I believe this compound will play a more active role in future production and life.

To a cooled (0 C) solution of NaH (60 % oil dispersion, 832 mg, 20.8 mmol) and 4-formylimidazole (2.0 g, 20.8 mmol) in dry DMF (30 mL) was added dropwise iodomethane (1.5 mL, 23.0 mmol). The reaction mixture was stirred at rt for 1.5 hr. After quenching the reaction with water, the solvent was removed by evaporation. The residue was dissolved in water and extracted with CHCl3. The extracts were dried over MgSO4 and concentrated by evaporation. The residue was purified by flash column chromatography on SiO2 (CHCl3 ? CHCl3 : MeOH = 100 : 1 ? 50 : 1 ? 10 : 1) to give 36 (1.2 g, 53 %) as a pale yellow solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Imidazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Fuchida, Hirokazu; Tabata, Shigekazu; Shindo, Naoya; Takashima, Ippei; Leng, Qiao; Hatsuyama, Yuji; Hamachi, Itaru; Ojida, Akio; Bulletin of the Chemical Society of Japan; vol. 88; 6; (2015); p. 784 – 791;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 3034-50-2, These common heterocyclic compound, 3034-50-2, name is Imidazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 3C (4.35 g, 21.16 mmol) in anhydrous dichloroethane (60 mL) was treated with imidazole-4-carboxaldehye (1B, 2.79 g, 28.99 mmol) and AcOH (0.35 mL, 6 mmol). The mixture was stirred at RT for 10 min and then treated with NaBH(OAc)3 (15.36 g, 72.48 mmol). The reaction mixture was stirred at RT overnight, and quenched with 2N NaOH solution, concentrated under vacuum. The residue was diluted with water (50 mL) and extracted with EtOAc (4¡Á100 mL). The organic layer was dried (MgSO4), filtered, and concentrated under vacuum. Chromatography (DCM containing 1 to 5% of 7N NH3 in MeOH) provided 3D (5.56 g, 89%). MS m/z 261 (MH+).

The synthetic route of 3034-50-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Schering Corporation and Pharmacopeia Drug Discovery, Inc.; US2007/93477; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 3034-50-2,Some common heterocyclic compound, 3034-50-2, name is Imidazole-4-carbaldehyde, molecular formula is C4H4N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(i) Preparation of 1-(triphenylmethyl)-1H-imidazol-4-carboxaldehyde (7): To a stirred suspension of 4-imidazole carboxaldehyde (from Maybridge Chemicals, United Kingdom) (35.0 g, 364 mmol) and triethylamine (55.8 mL; 400 mmol) in dichloromethane (2 L), was added a solution of triphenylmethyl chloride in dichloromethane (600 mL) while maintaining the reaction temperature at approximately 15 C. with a cooling bath. The resultant solution was warmed to room temperature and stirred for 19 h. Washed the reaction solution with a solution of saturated brine and water (1:3.5; 3*600 mL), followed by brine (1*800 mL). Dried over sodium sulfate; filtered to remove drying agent; and removed solvent under vacuum to obtain the desired tritylated product (7) as an off-white solid. MP 186.5-194 C. [Trituration of this product with ether yielded a cream-colored powder with mp 195-197 C.]

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Imidazole-4-carbaldehyde, its application will become more common.

Reference:
Patent; Shih, Neng-Yang; Aslanian, Robert G.; Piwinski, John J.; Lupo JR., Andrew T.; Afonso, Adriano; US2002/82272; (2002); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3034-50-2, name is Imidazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C4H4N2O

To a suspension of 10 (4.94 g, 51.4 mmol) in dry THF (30 mL) was added NaH (2.48 g, assey 60%, 61.9mmol, 1.2 eq) at -78 C under argon atmosphere, and stirred for 10 min at rt. The reaction mixture was cooledto -78 C and added MeI (3.9 ml, 62.6 mmol, 1.2 eq) dropwise at -78 C. The mixture was gradually warmed to rt and stirred for 18 h. The mixture was quenched with MeOH, then concentrated in vacuo. The residue was dissolved with CH2Cl2 and the solution was filtered through a pad of Celite to afford the crude product, which was purified by silica gel chromatography (20:1 CHCl3 / MeOH) to afford 15 (5.58 g, 99%) as a yellow oil. 1H NMR (500 MHz, CDCl3) delta 3.79 (s, 3H), 7.53 (s, 1H), 7.60 (s, 1H), 9.88 (s, 1H)

According to the analysis of related databases, 3034-50-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Yamashita, Megumi; Shimizu, Keita; Koizumi, Yasuaki; Wakimoto, Toshiyuki; Hamashima, Yoshitaka; Asakawa, Tomohiro; Inai, Makoto; Kan, Toshiyuki; Synlett; vol. 27; 19; (2016); p. 2734 – 2736;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 3034-50-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3034-50-2, name is Imidazole-4-carbaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a stirring solution of 1H-imidazole-4-carbaldehyde (2.00 g, 20.81 mmol) in THF (20 mL) was added DMAP (0.64 g, 5.20 mmol) and TEA (5.80 ml, 41.60 mmol) followed by Boc-anhydride (5.80 mL, 24.98 mmol) and the resulting reaction mixture was stirred as ambient temperature for 18 h. The reaction mixture was concentrated to dryness under reduced pressure and diluted with water (50 mL). The solid precipitate was filtered and dried under vacuum to obtain Intermediate 130A (2.50 g, 49.00%) as a pale yellow solid. 1H NMR (400 MHz, DMSO-d6) G ppm 1.59 (s, 9 H), 8.37-8.39 ( d, J = 5.40 Hz, 2 H), 9.80 (s., 1 H). LCMS (Method-O): retention time 1.00 min, [M-56] 141.2.

The synthetic route of Imidazole-4-carbaldehyde has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; YADAV, Navnath Dnyanoba; BHIDE, Rajeev S.; BORA, Rajesh Onkardas; GUNAGA, Prashantha; PANDA, Manoranjan; PRIESTLEY, Eldon Scott; RICHTER, Jeremy; (444 pag.)WO2018/222795; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3034-50-2, name is Imidazole-4-carbaldehyde, A new synthetic method of this compound is introduced below., Recommanded Product: 3034-50-2

First, 4-imidazole formaldehyde (1a, 960 mg, 10 mmol) was added to the reaction flask.Place in ice water bath. After 10min,Add triethylamine (TEA) (278 mul, 2.0 mmol) to the reaction flask,The mixture was stirred in an ice-water bath for 5 min.Di-tert-butyl dicarbonate (2.4 g, 1.0 mmol) was then added to the reaction flask.The reaction was moved to room temperature and reacted overnight. After the reaction was detected by TLC, the solvent was spin-dried.Alumina column chromatography (PE: EA = 2: 1) gave Intermediate 1b.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Xihua University; Wang Zhouyu; Qian Shan; Yang Lingling; Li Ling; Xu Wei; Yang Huan; Liu Siyan; Yao Hao; Yan Jie; Li Chao; (23 pag.)CN110294714; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem