Category: 3034-38-6

Some common heterocyclic compound, 3034-38-6, name is 5-Nitro-1H-imidazole, molecular formula is C3H3N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 3034-38-6

Nitroimidazole (4.52 g, 40 mmol) was dissolved in conc. aq NH3 (70 mL) to give a clear yellow solution. A solution of silver nitrate (6.8 g, 40 mmol) in water (40 mL) was added dropwise(20 min) with moderate stirring at rt. After further stirring (10 min) the resultant pale yellow precipitate was filtered off, washed well with ethanol and dried under high vacuum to give the product 11 (8.16 g, 93%) as apale yellow/white chalky powder. mp >300 C (lit.17, > 300 C). 1H NMR (250.1 MHz, DMSO-d6): d 7.34 (s, 1H,CH), 7.89 (s, 1H, CH), not observed (CNO2). MS (CI) m/z (%) 112 (M-, 100).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3034-38-6, its application will become more common.

Reference:
Article; Clayton, Russell; Davis, Michael L.; Li, Wei; Fraser, William; Ramsden, Christopher A.; Arkivoc; vol. 2017; 3; (2017); p. 87 – 104;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3034-38-6 as follows. HPLC of Formula: C3H3N3O2

General procedure: A mixture of 1.6 mmol of C-nitro-NH-azole (1a-e), 2.6 mmol of arylboronic acid (2a-n), 1.6 mmol of sodium hydroxide, 0.2 mmol of CuCl2 and methanol (15 mL) was refluxed while air was bubbled through the reaction mixture. After completion of the reaction, determined on the basis of TLC analysis, the solvent was removed under reduced pressure using a rotary evaporator. The obtained crude product was purified by silica gel column chromatography with 5:95 v/v MeOH/CHCl3 as an eluent to give corresponding N-aryl-C-nitroazole. The product was crystallized from methanol/water.

According to the analysis of related databases, 3034-38-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kurpet, Marta K.; Dabrowska, Aleksandra; Jarosz, Malgorzata M.; Kajewska-Kania, Katarzyna; Kuznik, Nikodem; Suwinski, Jerzy W.; Beilstein Journal of Organic Chemistry; vol. 9; (2013); p. 1517 – 1525;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem