Category: 30148-21-1

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 30148-21-1, name is Ethyl 1-methyl-1H-imidazole-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., category: imidazoles-derivatives

A solution of the methylimidazole (3.2 mL, 40.0 mmol) in 30 mL de CH3CN:Et3N (2:1) was cooled to -30 C and quickly added to a previously prepared solution of ethyl chloroformiate (7 mL, 66.0 mmol) in 10 mL of CH3CN. The mixture was stirred for 15h at rt. The solvents were removed under reduced pressure; the crude was re-dissolved in water (20 mL) and extracted with chloroform (3 × 20 mL). The organic fractions were dried and concentrated, and the resulting residue was purified by flash cromatography (aluminum oxide, 90% MeOH) to give 3.72 g of a crude ester residue which was directly used for the next step. A solution of this residue (1.5 g, 9.74 mmol) in 15 mL of aqueous NaOH (1 M) was refluxed for 1 h. The resulting mixture was acidified to pH 2.0 using HCl 10% (aprox.15 mL) and lyophilized. The crude was dissolved in MeOH and concentrated underreduced pressure to give 12 as a slighlty pink solid (1.2 g, 98%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 30148-21-1.

Reference:
Article; Jimenez-Balsa, Adrian; Dodero, Veronica I.; Mascarenas, Jose L.; Tetrahedron; vol. 69; 36; (2013); p. 7847 – 7853;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Some common heterocyclic compound, 30148-21-1, name is Ethyl 1-methyl-1H-imidazole-2-carboxylate, molecular formula is C7H10N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 30148-21-1

General procedure: To the solution of ester (10 mmol) in THF (20 mL) and ethyl acetate (70 mmol), LiHMDS (30 mmol) was added very quickly at -40 C, and stirred at this temperature for 20 min. After completion of the reaction, reaction mixture was quenched with acetic acid (50 mmol) and then basified using 10% NaHCO3 solution, extracted with ethyl acetate (2×100 mL), the combined organic layer was washed with water and brine solution and dried over Na2SO4. The specific purification procedure for each compound has been included along with their characterization data.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 30148-21-1, its application will become more common.

Reference:
Article; Venkat Ragavan; Vijayakumar; Rajesh; Palakshi Reddy; Karthikeyan; Suchetha Kumari; Bioorganic and Medicinal Chemistry Letters; vol. 22; 12; (2012); p. 4193 – 4197;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 30148-21-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 30148-21-1, name is Ethyl 1-methyl-1H-imidazole-2-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

(S)-[2-(hydroxydim-tolylmethyl)pyrrolidin-1-yl](1-methyl-imidazol-2-yl)methanone was first prepared by dissolving (S)-a,a-Di(3-methylphenyl)prolinol (prepared as described above, 0.8 g, 2.85 mmol) in toluene (10 mL) and NaH (60 % dispersion in mineral oil, 148 mg,3.7 mmol) added at room temperature. After stirring for 30 mins, ethyl-1-methylimidazole-2-carboxylate (527 mg, 3.4 mmol) was added. The resulting reaction mixture was slowly warm to 70 C and stirred for 24 h at the same temperature. The reaction was cooled to room temperature, quenched by addition of saturated aqueous NH4CI (20 mL) and extracted with dichloromethane (3 x 20 mL). The combined organic extracts were washed with brine (20 mL) and dried over magnesium sulfate. After filtration, the filtrate was evaporated and purified by chromatography on silica gel (10% to 50% ethyl acetate in petroleum ether) to yield the product (0.53 g, 48 %) as white solid; m.p. 162-164C;[a]D-95.5 (c1 .1 in CHCI3);vmax (thin film, cm -1) 2952, 1615, 1456, 1282; deltaEta (500 MHz, d6-DMSO, 100 C) 1 .66-1 .75 (m, 1 H, 1 xCH2), 1 .78-1 .86 (m, 1 H, 1 chi CH2), 1 .93-1 .97 (m, 1 H, 1 chi CH2), 2.05-2.12 (m, 1 H, 1 chi CH2), 2.14 (s, 3H, CH3), 2.29(s, 3H, CH3), 3.36 (s, 3H, NCH3), 3.47-3.52 (m, 1 H, 1 chi CH2), 3.87- 3.92 (m, 1 H, 1 x CH2), 5.68 (s, 1 H, NCH), 6.14 (br, s, 1 H, OH), 6.85-6.87 (m, 2H, ArH), 6.91 – 6.98 (m, 4H, ArH), 7.04 (app. d, 1 H, J 7.7, ArH), 7.18-7.24 (m, 2H, ArH), 7.28 (s, 1 H, ArH); deltaC (126 MHz, d6-DMSO, 100C) 20.6(2 x CH3), 22.2(CH2),27.2 (CH2), 33.6 (CH3),47.4(NCH2), 63.5(NCH), 80.1 (COH), 123.2, 123.3, 123.6, 125.3, 125.9, 126.2, 126.6, 126.9, 127.2, 135.2, 136.1 , 140.2, 145.3, 145.4, 158.9 ( CO) ;mlz (TOF ES+) 390.2188 (100%, MH+, C24H28N3O2 requires 390.2182), 372.2092 (20).

The synthetic route of Ethyl 1-methyl-1H-imidazole-2-carboxylate has been constantly updated, and we look forward to future research findings.

Synthetic Route of 30148-21-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 30148-21-1, name is Ethyl 1-methyl-1H-imidazole-2-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Preparation of Ethyl 4-nitro-1-methylimidazole-2-carboxylate (10) Compound (17) was carefully dissolved in 1000 ml of concentrated sulfuric acid cooled to 0 C. 90% nitric acid (1 liter) was slowly added maintaining a temperature of 0 C. The reaction was then refluxed with an efficient condenser (-20 C.) in a well ventilated hood for 50 minutes. The reaction was cooled with an ice bath, and quenched by pouring onto 10 liters of ice. The resulting blue solution was then extracted with 20 liters of dichloromethane and the combined extracts were dried and concentrated in vacuo to yield a tan solid which was recrystallized from 22 liters of 21:1 carbon tetrachloride/ethanol. The resulting white crystals were collected by vacuum filtration to provide pure (10). (103 g, 22% yield). TLC (7:2 benzene/ethyl acetate) Rf 0.5, 1 H NMR (DMSO-d6) delta 8.61 (s, 1 H), 4.33 (1, 2 H, J=6.4 Hz), 3.97 (s, 3 H), 1.29 (t, 3 H, J=6.0 Hz); 13 C NMR (DMSO-d6) delta 158.2, 145.4, 135.3, 127.4, 62.2, 37.3, 14.5; IR(KBr) 3139, 1719, 1541, 1508, 1498, 1381, 1310, 1260, 1147, 1122, 995, 860, 827, 656; FABMS m/e 200.066 (M+H 200.067 calc. for C7 H10 N3 O4).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 1-methyl-1H-imidazole-2-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; California Institute of Technology; US6090947; (2000); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

30148-21-1, name is Ethyl 1-methyl-1H-imidazole-2-carboxylate, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C7H10N2O2

A solution of the methylimidazole (3.2 mL, 40.0 mmol) in 30 mL de CH3CN:Et3N (2:1) was cooled to -30 C and quickly added to a previously prepared solution of ethyl chloroformiate (7 mL, 66.0 mmol) in 10 mL of CH3CN. The mixture was stirred for 15h at rt. The solvents were removed under reduced pressure; the crude was re-dissolved in water (20 mL) and extracted with chloroform (3 ¡Á 20 mL). The organic fractions were dried and concentrated, and the resulting residue was purified by flash cromatography (aluminum oxide, 90% MeOH) to give 3.72 g of a crude ester residue which was directly used for the next step. A solution of this residue (1.5 g, 9.74 mmol) in 15 mL of aqueous NaOH (1 M) was refluxed for 1 h. The resulting mixture was acidified to pH 2.0 using HCl 10% (aprox.15 mL) and lyophilized. The crude was dissolved in MeOH and concentrated underreduced pressure to give 12 as a slighlty pink solid (1.2 g, 98%).

The synthetic route of 30148-21-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Jimenez-Balsa, Adrian; Dodero, Veronica I.; Mascarenas, Jose L.; Tetrahedron; vol. 69; 36; (2013); p. 7847 – 7853;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Some common heterocyclic compound, 30148-21-1, name is Ethyl 1-methyl-1H-imidazole-2-carboxylate, molecular formula is C7H10N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of Ethyl 1-methyl-1H-imidazole-2-carboxylate

Step 6a. A solution of ethyl 1 -methyl- lH-imidazole-2-carboxy late (2.0 g, 13 mmol) in 8 ml cone. H2SO4 and 8 ml cone. HNO3 was stirred for 3 hours at 70C. The solution was diluted with H2O, then adjusted to pH 7-8 with aq Na2C03 solution and extracted with DCM. The organic layer was concentrated and chromatographed (silica, ethyl acetate/petroleum ether) to give the desired compound as yellow solid (0.9g, 34.7%). ESI- MS m/z = 200.20 [M+H]+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 30148-21-1, its application will become more common.

Reference:
Patent; ENANTA PHARMACEUTICALS, INC.; QIU, Yao-ling; LI, Wei; CAO, Hui; JIN, Meizhong; GAO, Xuri; PENG, Xiaowen; KASS, Jorden; OR, Yat, Sun; (84 pag.)WO2016/183266; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 30148-21-1,Some common heterocyclic compound, 30148-21-1, name is Ethyl 1-methyl-1H-imidazole-2-carboxylate, molecular formula is C7H10N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

IM-1 (1.8 g) was dissolved in concentrated H2S04 (5 mL) and cooled to 0C. Nitric acid (90%, 5 mL) was slowly added and the solution warmed to room temperature and then refluxed at-20C for 1.5 hr. The reaction was quenched by pouring onto ice (50 mL). The resulting blue solution was extracted with DCM, dried over sodium sulphate, and evaporated under vacuum to yield a tanned and oily product. The residue was precipitated with CCL4 : EtOH (1 : 1, 5 mL) to yield the product as white crystals. Yield (1.0543 g, 45%). H NMR (DMSO): 6 8.61 (s, 1H), 4.33 (q, 2H, J=6. 4 Hz), 3.97 (s, 3H), 1.29 (t, 3H, J=6. 0 HZ). 13C (DMSO) : 158.2, 145.4, 135.3, 127.4, 62.2, 37.3, 14.5.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 1-methyl-1H-imidazole-2-carboxylate, its application will become more common.

Reference:
Patent; UNIVERSITY OF WESTERN SYDNEY; WO2005/33077; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem