Category: 30086-64-7

Daghlavi, Amneh; Kowsari, Elaheh; Abdouss, Majid; Ghasemi, Mohammad Hadi; Asadi, Elham published the artcile< Catalytic synthesis of thiazolidines by the reaction of Nef-isocyanide reaction>, COA of Formula: C7H12N2S, the main research area is phosphoric acid graphene oxide catalyst preparation thiazolidine Nef isocyanide.

A practical and efficient method for the synthesis of thiazolidine derivatives via Nef-isocyanide three-component reaction using supported phosphoric acid on graphene oxide (GO-H2PO4) is described. A relatively simple method starting with cyclic and acyclic thiourea was employed. The catalyst was characterized using FTIR, SEM, energy-dispersive x-ray spectroscopy, and X-ray diffraction techniques. Using a combination of acetonitrile as solvent and GO-H2PO4 as a catalytic system, the best results were obtained. All products were characterized using m.p., FTIR, MASS, 1H NMR, and 13C NMR techniques. The use of com. available chems., reusability of the catalyst, high yields, decreased environmental hazards, with no need for the separation of stereoisomers, and, consequently, a reduced number of overall steps are the advantages of this approach that make it an appropriate choice at an increased scale.

Research on Chemical Intermediates published new progress about Imidazoles Role: SPN (Synthetic Preparation), PREP (Preparation). 30086-64-7 belongs to class imidazoles-derivatives, and the molecular formula is C7H12N2S, COA of Formula: C7H12N2S.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Mardaneh, Jalal; Beyzaei, Hamid; Hashemi, Seyed Hadi; Ghasemi, Behzad; Rahdar, Abbas published the artcile< Comparative evaluation of the inhibitory potential of synthetic N-heterocycles, Cu/Fe3O4@SiO2 nanocomposites and some natural products against non-resistant and antibiotic-resistant Acinetobacter baumannii>, Application In Synthesis of 30086-64-7, the main research area is Acinetobacter Trachyspermum thiazole iron oxide silicon dioxide nanocomposite antibacterial.

Acinetobacter baumannii is a common infectious agent in hospitals. New antimicrobial agents are identified and prepared to combat these bacterial pathogens. In this context, the blocking potentials of a series of synthesized N-heterocyclic compounds, Cu/Fe3O4@SiO2 nanocomposites, glycine, poly-L-lysine, nisin and hydroalcoholic extracts of Trachyspermum ammi, Curcuma longa and green tea catechins were evaluated against non-resistant and multidrug-resistant strains of A. baumannii. Solutions of heterocyclic derivatives and hydroalcoholic extracts of Trachyspermum ammi, Curcuma longa and green tea catechins were prepared at initial concentration of 10240μg ml-1 in 10% DMSO. Other compounds were dissolved in water at the same concentrations Their in vitro inhibitory activity was assessed by determination of IZD, MIC and MBC values. Glycine, poly-L-lysine, nisin, Curcuma longa and green tea catechins extracts, and thiazoles 3a, 3d and 3f were ineffective at their initial concentrations Heterocyclic derivatives 7a-f, 3c, 3e and 3h, Cu/Fe3O4@SiO2 nanocomposites and Trachyspermum ammi extract could block the growth of bacterial strains with IZDs (7.40-15.51 mm), MICs (32-1024μg ml-1) and MBCs (128-2048μg ml-1). Among synthetic chems. and natural products, the best antimicrobial effects were recorded with (E)-2-(5-acetyl-4-methylthiazol-2-yl)-2-(thiazolidin-2-ylidene)acetonitrile (7b) and the extract of Trachyspermum ammi. It is imperative that their toxic and histopathol. effects were assessed in future researches. It is predicted that the essential oil of Trachyspermum ammi will improve its antibacterial activities.

Pharmaceutical Sciences (Tabriz, Islamic Republic of Iran) published new progress about Acinetobacter baumannii. 30086-64-7 belongs to class imidazoles-derivatives, and the molecular formula is C7H12N2S, Application In Synthesis of 30086-64-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 30086-64-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 30086-64-7 as follows.

Compound 55 (12.5 g, 80.12 mmol) was dissolved in MeOH (250 ml) and Mel (17.1 g, 120.2 mmol) was added. The resulting mixture was refluxed for 2 h. The volatileswere removed under reduced pressure yielding SC, (13.5 g Yield: 99%) as oWwhite solid that was used without further purification.

According to the analysis of related databases, 30086-64-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NANJING GATOR MEDITECH COMPANY, LTD.; IWANOWICZ, Edwin, J.; (94 pag.)WO2018/31987; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 30086-64-7, A common heterocyclic compound, 30086-64-7, name is Hexahydro-1H-benzo[d]imidazole-2(3H)-thione, molecular formula is C7H12N2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of cyclic thiourea 4a-e (1 mmol) and di(methylsulfanyl)methylenemalononitrile 5a (0.170 g, 1 mmol) in DMF (3 mL) was stirred at 120 C. Upon completion (3 h monitored by TLC), the solvent was removed by rotary evaporator under vacuum. The afforded orange solid washed by ethyl acetate and dried to give 1.

The synthetic route of 30086-64-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Alizadeh, Abdolali; Vahabi, Amir Hossein; Bazgir, Ayoob; Khavasi, Hamid Reza; Zhu, Zhe; Zhu, Long-Guan; Tetrahedron; vol. 72; 10; (2016); p. 1342 – 1350;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 30086-64-7,Some common heterocyclic compound, 30086-64-7, name is Hexahydro-1H-benzo[d]imidazole-2(3H)-thione, molecular formula is C7H12N2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of alkyl chloroglyoxalates (5 mmol), cyclohexyl isocyanide (Cy-CN,5 mmol), and thiourea derivatives (5 mmol) was added to a mixture of GO-H2PO4(0.1 g) in acetonitrile for 2 h at 50 C. The catalyst was removed by filtration, and the solvent was evaporated to yield 4-hydroxy-thiazolidine-4-carboxylates. All products are solid and purified by recrystallization in ethanol.

The synthetic route of 30086-64-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Abdouss, Majid; Asadi, Elham; Daghlavi, Amneh; Ghasemi, Mohammad Hadi; Kowsari, Elaheh; Research on Chemical Intermediates; (2020);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem