Category: 29518-68-1

These common heterocyclic compound, 29518-68-1, name is 2-(1H-Benzo[d]imidazol-2-yl)ethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 29518-68-1

Step 2; N3-[4-[2-(Benzimidazol-2-yl)ethyl)aminomethylbenzoyl)-N2-Cbz-L-2,3-diaminopropionic acid on 2-chlorotrityl resin; [Show Image] Shake the resin (Preparation 4, Step 1) (0.8 g, 0.4 mmol) and 2-[2-(aminoethyl)]benzimidazole (3.25 g) in DMF (25 mL) in a sealed vial for 44 hours. Transfer resin to funnel apparatus, and wash the resin with DMF (25 mL x 5) and then CH2Cl2 (20 mL x 5) to give the title resin.

The synthetic route of 2-(1H-Benzo[d]imidazol-2-yl)ethanamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SCHERING CORPORATION; EP1135374; (2006); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

These common heterocyclic compound, 29518-68-1, name is 2-(1H-Benzo[d]imidazol-2-yl)ethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C9H11N3

Step 2; N3-[4-[2-(Benzimidazol-2-yl)ethyl)aminomethylbenzoyl)-N2-Cbz-L-2,3-diaminopropionic acid on 2-chlorotrityl resin; [Show Image] Shake the resin (Preparation 4, Step 1) (0.8 g, 0.4 mmol) and 2-[2-(aminoethyl)]benzimidazole (3.25 g) in DMF (25 mL) in a sealed vial for 44 hours. Transfer resin to funnel apparatus, and wash the resin with DMF (25 mL x 5) and then CH2Cl2 (20 mL x 5) to give the title resin.

The synthetic route of 2-(1H-Benzo[d]imidazol-2-yl)ethanamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SCHERING CORPORATION; EP1135374; (2006); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 29518-68-1,Some common heterocyclic compound, 29518-68-1, name is 2-(1H-Benzo[d]imidazol-2-yl)ethanamine, molecular formula is C9H11N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under argon protection, [RuCl2(C6H6)] 28.2 mg (0.0164 mmol) and (S)-SEGPHOS 20 mg (0.0328 mmol) was suspended in 2 ml of argon gas degassed DMF.Stir at 100 C for 1 hour; The solvent was removed under vacuum at 50 C. Obtained a brown solid; Then, add beta-bimaH 5.3 mg (0.0328 mmol) and2.6 ml of argon gas degassed DCM (dichloromethane)-methanol mixed solvent (DCM:methanol = 10:3),Then add Et3N9.9mg (0.0984mmol),Stir at room temperature for 12 hours under argon protection; The solvent was removed in vacuo, 3 mL DCM was added and filtered.The filtrate was concentrated under reduced pressure to about 0.5 ml.Add 3 ml of n-hexane to precipitate, filter, wash twice with 3 mL of diethyl ether, and dry in vacuo.The product was obtained in 23.3 mg (yield 76%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(1H-Benzo[d]imidazol-2-yl)ethanamine, its application will become more common.

Reference:
Patent; Zhongshanyi Antai Pharmaceutical Technology Co., Ltd.; Ke Lisidian·A·shanduofu; Xu Liang; Pa Telike·boermate; A Shenli·woke; (18 pag.)CN103889995; (2016); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 29518-68-1, name is 2-(1H-Benzo[d]imidazol-2-yl)ethanamine, A new synthetic method of this compound is introduced below., Product Details of 29518-68-1

General procedure: To a 50-ml glass round-bottom flask was added sequentially the primary amine 2 (1.0 mmol; aliphatic, aromatic or heteroaromatic; as free naked amine or as HCl, MsOH, TsOH or tartrate salt), FSO2N3 solution (containing 1.0 mmol FSO2N3, approximately 200 mM in DMF/MTBE 1:1, v/v, approximately 5 ml, volume adjusted according to the concentration; prepared according to the above procedure and diluted with equal volume of DMF) and aqueous KHCO3 solution (3.0 M, 1.33 ml, containing 4.0 mmol KHCO3). The reaction mixture was stirred for 5 min at room temperature, while monitoring by LC-MS. After completion, EtOAc (40 ml) was added and the mixture was washed sequentially with brine (60 ml × 6), water (60 ml × 2) and brine (60 ml), dried over Na2SO4, concentrated by rotary evaporation and dried under vacuum to afford the azide product 3. For products containing acidic functional groups, this extraction process was modified with acidified aqueous phase (acidified with aqueous HCl). Detailed procedures and the various modifications, as well as the characterization data for each compound, can be found in Supplementary Information 1.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Meng, Genyi; Guo, Taijie; Ma, Tiancheng; Zhang, Jiong; Shen, Yucheng; Sharpless, Karl Barry; Dong, Jiajia; Nature; vol. 574; 7776; (2019); p. 86 – 89;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 29518-68-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 29518-68-1 name is 2-(1H-Benzo[d]imidazol-2-yl)ethanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A suitable round bottom flask or reacti-vial was charged with aryl halide (1 equiv.), tryptamine (1.1 equiv.), IPA (lOmL/mmol) and triethylamine (2 equiv.) and heated at 100C for 3 h (reaction monitored by UPLC analysis). On cooling the reaction mixture was evaporated to dryness and the resultant residue partitioned between ethyl acetate and water. The organic phase was separated and sequentially washed with saturated bicarbonate solution, water, brine, then dried over sodium sulfate, filtered and evaporated. Purification, if required was performed by chromatography or trituration.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(1H-Benzo[d]imidazol-2-yl)ethanamine, and friends who are interested can also refer to it.

Reference:
Patent; JAGUAHR THERAPEUTICS PTE LTD; METE, Antonio; HITCHIN, James, R,; GRAHAM, Mark; KING-UNDERWOOD, John; THORNE, Philip, Vellacott,; (62 pag.)WO2020/39093; (2020); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 29518-68-1, These common heterocyclic compound, 29518-68-1, name is 2-(1H-Benzo[d]imidazol-2-yl)ethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Starting amino compound (0.238 mmol) was dissolved in THF (25 mL) and triethylamine (10 drops) was added to the stirred solution. Acyl halide (0.149 mmol) was added dropwise to the stirred solution, which was then heated under reflux for 3h. The reaction mixture was concentrated under reduced pressure. The residue was dissolved in EtOAc and washed with aq. K2CO3 solution followed by brine. The organic layer was then dried over Na2SO4, filtered, and concentrated in vacuo. The residue was purified by silica gel column chromatography eluting with 1-5 methanol/DCM v/v.

Statistics shows that 2-(1H-Benzo[d]imidazol-2-yl)ethanamine is playing an increasingly important role. we look forward to future research findings about 29518-68-1.

Reference:
Article; Elshihawy, Hosam; Helal, Mohamed A.; Said, Mohamed; Hammad, Mohamed A.; Bioorganic and Medicinal Chemistry; vol. 22; 1; (2014); p. 550 – 558;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 29518-68-1, name is 2-(1H-Benzo[d]imidazol-2-yl)ethanamine, A new synthetic method of this compound is introduced below., Quality Control of 2-(1H-Benzo[d]imidazol-2-yl)ethanamine

STEP A: {1-[2-(1H-Benzoimidazol-2-yl)-ethylcarbamoyl]-2-thiophen-2-yl-ethyl}-(S)-carbamic acid tert-butyl ester A 50 mL round bottom flask was charged with (S)-2-(tert-butoxycarbonylamino)-3-(thiophen-2-yl)propanoic acid (300 mg, 1.10 mmol), 1-hydroxybenzotriazole hydrate (75 mg, 0.55 mmol), O-benzotriazole-N,N,N’, N’-tetramethyl-uronium-hexafluorophosphate (500 mg, 1.33 mmol), and dimethylformamide (5.0 mL). Triethylamine (0.77 mL, 0.55 mmol) and 2-(1H-benzo[d]imidazol-2-yl)ethanamine (388.2 mg, 1.66 mmol) were added and the resulting mixture stirred at room temperature for 22 h. The resulting mixture was then concentrated in vacuo and the residue purified via flash silica gel chromatography (ISCO, SF25-40 g column, gradient 90:10-75:25 Heptane:EtOAc) to yield {1-[2-(1H-benzoimidazol-2-yl)-ethylcarbamoyl]-2-thiophen-2-yl-ethyl}-(S)-carbamic acid tert-butyl ester. 1H NMR (300 MHz, CDCl3) 6.7.73-7.69 (m, 2H), 7.29-7.37 (m, 2H), 7.54-7.33 (m, 4H), 7.11 (d, J=8.2 Hz, 1H), 6.82-6.88 (m, 2H), 5.32 (t, J=3.71 Hz, 1H), 4.33 (m, 1H), 3.78-3.97 (s, 2H), 3.45-3.35 (m, 2H), 3.15-2.91 (m, 4H) and 1.41-1.21 (m, 9 H); MS (ES+) 415 (M+1).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Lawson, Edward C.; Hlasta, Dennis J.; Ghosh, Shyamali; DesJarlais, Renee L.; Schubert, Carsten; US2011/152321; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 29518-68-1, name is 2-(1H-Benzo[d]imidazol-2-yl)ethanamine, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 29518-68-1, Recommanded Product: 2-(1H-Benzo[d]imidazol-2-yl)ethanamine

Carbonyldiimidazole (23.4 g; 0.145 mol) was added to a solution of glutaric acid (8 g; 0.06 mol) in anhydrous tetrahydrofuran (500 ml) and stirred for 2 hours. Then benzimidazolyl ethylamine (21.6 g; 0.133 mol) was added to the reaction mixture. The resulting solution was stirred for 3 hours and allowed to stand at room temperature. The residue of the product was separated, washed with water, and dried. The yield was 21 g (82.9%). Rf 0.21 (2). M.p. 170-170.5 C. [M]+419. 1H-NMR (DMSO): delta, m.d.: 1.61-1.76 (m, 2H, CH2), 1.95-2.07 (t, 2H, CH2), 2.9-3.0 (t, 4H, 2CH2), 3.45-3.55 (quint, 4H, 2CH2), 7.06-7.14 (m, 4H, Ar), 7.39-7.54 (m, 4H, Ar), 7.98-8.08 (t, 2H, Ar), 11.6-12.7 (s, 2H, NH). HPLC under condition B: an individual peak at a retention time of 26.6 min.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTIYU “PHARMENTERPRISES”; NEBOLSIN, Vladimir Evgenievich; KROMOVA, Tatyana Alexandrovna; ZHELTUKHINA, Galina Alexandrovna; (19 pag.)US2016/31858; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 29518-68-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 29518-68-1, name is 2-(1H-Benzo[d]imidazol-2-yl)ethanamine belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

(a) 1 -[2-(I H-B enzimidazol-2-y) ethyl] thiourea; {2-(lH-Benzimidazol-2-yl)ethylamine was made as the dihydrochloride salt according to a procedure described by Nicolaou etaJ. Bioorg. Med. Chem., 1998, 6, 1185-1208 and pretreated with DIPEA (2.07 mL, 11.86 mmol) for 5 minutes.} To a suspension of 2-(1H- benzimidazol-2-yl)ethylarnine (1.39 g, 5.93 mmol) in dichloromethane (20 mL) was added benzoyl isothiocyanate (0.88 mL, 6.52 mmol). After 1 h, the reaction mixture was concentrated in vacuo. Ammonia in methanol (7N, 30 mL) was then added and the reaction stirred another 4 h. The excess ammonia and methanol were removed in vacuo and dichloromethane (15 mL) was added. The solid was removed by filtration and the filtrate concentrated in vacuo and purified by flash chromatography (methanol/dichloromethane, 5% thenltheta%) to give the title compound as a solid (1.12 g, 86% yield). 1H NMR (DMSO-de) delta ppm 12.28 (IH), 7.85-7.62 (2H), 7.49 (2H), 7.15-7.10 (2H), 7.05 (IH), 3.86 (2H), 3.04 (2H); MS (ESI) m/z 221 (M+l).

The synthetic route of 2-(1H-Benzo[d]imidazol-2-yl)ethanamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; WO2007/120098; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 29518-68-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 29518-68-1 name is 2-(1H-Benzo[d]imidazol-2-yl)ethanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a 20 mL scintillation vial was added isoxazolidine 60 (20 mg) and 1-H-benzimidazole-2-ethanamine (72.1 mg) followed by 0.35 M 2-hydroxypyridine solution (0.7 mL). The solution was heated to 50 C. for 19 h and then diluted with ethyl acetate (10 mL) and water (10 mL). The organic layer was separated and concentrated in vacuo. The title compound was purified by preparative TLC (1000 microns, silica) eluting with 95:5 ethyl acetate/methanol to yield 12.7 mg of the desired product as a solid. MS (ESI(+)) m/e 539.0 (M+H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(1H-Benzo[d]imidazol-2-yl)ethanamine, and friends who are interested can also refer to it.

Reference:
Patent; Infinity Pharmaceuticals, Inc.; US2006/20004; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem