Category: 28890-99-5

Adding a certain compound to certain chemical reactions, such as: 28890-99-5, name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 28890-99-5, COA of Formula: C13H9N3

d) Compound 8-3 (3.0 g, 8.10 mmol), benzimidazolo[1,2-a]benzimidazole (1.85 g, 8.91mmol), and potassium phosphate (1.96 g, 16.2 mmol) were added to NMP (30 mL). Themixture was stirred at 190 C for 17 h. In addition, potassium phosphate (3.92 g, 32.4 mmol) was added there, and the mixture was stirred at the same temperature for 27 h. Af8-2 ter reaction mixture was cooled at room temperature, it was diluted with water to give asolid. The solid was collected by filtration, and it was washed with 300 mL of MeOH. Thecrude product was purified by by column chromatography on silica gel eluting with CH2CI2to yield 4.7 g (78%) of compound (B-29) as a white solid. LC-MS (m/z) 745.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, and friends who are interested can also refer to it.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; NISHIMAE, Yuichi; KOHLSTEDT, Julia; SCHAeFER, Thomas; NAGASHIMA, Hideaki; (114 pag.)WO2016/97983; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 28890-99-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 28890-99-5, name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

(3-bromophenyl)(9,9-dimethyl-9H-xanthen-4-yl)diphenylsilane (2, 300 mg, 0.55 mmol), 5H-benzo [d]benzo[4,5]imidazo[1,2-a]imidazole (3, 125 mg, 0.603 mg),cBRIDP (19.3 mg. 0.055 mmol) and tBuONa (132 mg, 1.37mmol) were dissolved in xylene (5 mL). The mixture wasdegassed by bubbling nitrogen through for 15 min. Alkylpalladiumchloride dimer (6 mg, 0.016 mmol) was added,and the mixture was again degassed by bubbling nitrogenthrough for another 15 min before being heated to 120 C.for 2 h. The reaction was quenched with water. The organicphase was separated and the aqueous phase was extractedwith dichloromethane. The combined organics was dried onMgS04 , filtered, and concentrated in vacuo. The crudeproduct was purified using reverse phase chromatography(20:80 to 70:30 THF:water, 1CV, 70:30 to 100:0 THF:water,10 CV, then THF). The crude product was then re-purifiedusing reverse phase chromatography (20:80 to 40:60 THF:water, 1 CV, 40:60 to 70:30 THF:water, 10 CV, then 70:30THF:water). The product was purified using normal phaseflash colunm chromatography (silica, 1:99 to 100:0 dichloromethane:heptane ). It was retained on the silica before 1:1THF:dichloromethane was used. This material was purifiedagain by normal phase chromatography (silica, 50:50 to100:0 dichloromethane:heptane) to afford Compound A aswhite solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Universal Display Corporation; Wolohan, Peter; Feldman, Jerald; (128 pag.)US2018/287079; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 28890-99-5,Some common heterocyclic compound, 28890-99-5, name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, molecular formula is C13H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

b) Compound 3-1 (1.55 g, 4.4 mmol), benzimidazolo[1,2-a]benzimidazole (960 mg, 4.6 mmol), and potassium phosphate (1.97 g, 9.3 mmol) were suspended in NMP (22 mL). The mixture was stirred at 190 Cfor 18.5 h. After the reaction mixture was cooled at roomtemperature, 44 mL of EtCH and 22 mL of water were added to the reaction mixture to give a solid. It was collected by filtration, and it was purifed by column chromatography on silica gel eluting with a mixed solvent of toluene and CHCI3.The product was further purified by recrystallization with toluene and cyclohexane to result in compound A-1O (yield: 1.55 g (65%)) as a white solid. LC-MS (mlz) 538.1HNMR (300 MHz, DMSO-c): 68.42-8.39 (m, 2H), 8.32-8.25 (m, 2H), 7.95-7.82 (m, 3H),7.72 (dd, J= 1.2, 7.6 Hz, 1H), 7.61-7.58 (m, 1H), 7.50-7.32 (m, 9H), 7.25 (t, J= 7.9 Hz,1H), 7.20-7.17 (m, 2H), 6.38 (dd, J= 1.1, 8.0 Hz, 1H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, its application will become more common.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; NISHIMAE, Yuichi; KOHLSTEDT, Julia; SCHAeFER, Thomas; NAGASHIMA, Hideaki; (114 pag.)WO2016/97983; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 28890-99-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 28890-99-5, name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Example 16 a) 7.00 g (24.7 mmol) 1-bromo-4-iodo-benzene, 10.5 g (32.2 mmol) caesium carbonate, 2.36 g (12.4 mmol) copper(I) iodide and 2.85 g (24.7 mmol) L-proline are added to 5.13 g (24.7 mmol) mmol) 5H-benzimidazo[1,2-a]benzimidazole in 80 ml DMSO under nitrogen. The reaction mixture is stirred for 15 h at 100 C. and 4 h at 150 C., filtered on Hyflo with dichloromethane. The organic phase is washed with water. The organic phase is dried with magnesium sulfate. The product is decocted with diethylether and methyl ethyl ketone (MEK). Yield: 2.90 g (77%).1H NMR (400 MHz, DMF-d7): delta 7.93-8.10 (m, 4H), 7.78-7.92 (m, 2H), 7.72-7.79 (m, 1H), 7.49-7.71 (m, 1H), 7.31-7.49 (m 4H). b) The product of Example 16b) is prepared in analogy to the procedure described in Example 4b).1H NMR (400 MHz, DMF-d7): delta=8.19-8.33 (m, 10H), 7.83-7.87 (m, 2H), 7.73-7.77 (m, 2H), 7.35-7.54 (m, 4H). One signal is covered by DMF MS (APCI(pos), m/z): 565 (M+1).

The synthetic route of 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASF SE; US2012/241681; (2012); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 28890-99-5, The chemical industry reduces the impact on the environment during synthesis 28890-99-5, name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, I believe this compound will play a more active role in future production and life.

5.00 g ( 36.0 mmol) 2,3-difluorobenzonitrile, 14.9 g (72.0 mmol) 6H-benzimidazolo[1 ,2- a]benzimidazole and 30.5 (144 mmol) potassium phosphate tribasic in 120 ml NMP (N-Methyl- 2-pyrrolidon) are stirred at 185 C under nitrogen for 6 h. The reaction mixture is filtered hot and the organic phase is poured on water. The product is filtered of. Column chromatography on silica gel with chloroform gives 6.25 g 33.9 % of the product. 1H NMR (300 MHz, DMSO-D6): rotamers: delta 8.43-8.57 (m, 2H), 7.58-8.20 (m, 6H), 6.86-7.42 (m, 9H), 6.63-7.78 (m, 1 H), 6.48-6.54 (m, 1 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; RAIMANN, Thomas; SCHAeFER, Thomas; SAITO, Masatoshi; WOLLEB, Heinz; BENEDITO, Flavio Luiz; NISHIMAE, Yuichi; NAKANO, Yuki; NAGASHIMA, Hideaki; (111 pag.)WO2016/157113; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 28890-99-5, name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 28890-99-5, Product Details of 28890-99-5

250ml four bottles,In the atmosphere of nitrogen gas,0.01 mol of 5H-benzimidazol [1,2-a] benzimidazole was added,0.015 mol of raw material C,0.03 mol of sodium tert-butoxide,1 x 10-4 mol Pd2 (dba) 3,1 x 10-4 mol tri-tert-butylphosphine,250ml toluene,Heated to reflux for 24 hours,Sampling point plate, the reaction is complete, natural cooling, filtration, the filtrate steamed, silica gel column, the target product, purity 95.26, yield 19.70%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, and friends who are interested can also refer to it.

Reference:
Patent; Jiangsu Sanyue Photoelectric Technology Co., Ltd.; Wang, Lichun; Li, Chong; Xu, Kai; Zhang, Zhaochao; Ye, Zhonghua; (39 pag.)CN106467552; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 28890-99-5, These common heterocyclic compound, 28890-99-5, name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 1 a) 20 g (96.5 mmol) 6H-benzimidazolo[1 ,2-a]benzimidazole is dissolved in 400 ml trifluoro- acetic acid under nitrogen. 43.4 g (193 mmol) N-lodosuccinimide is added in 10 minutes. The reaction mixture is stirred at 25 C for 24 h under nitrogen. The precipitated product is filtered off and crystalized from trifluoroacetic acid (yield: 19.2 g (43 %)). 1 H NMR (400 MHz, TFA-d1): delta 8.77-8-78 (m, 2H), 8.34-8.37 (m, 2H), 7.91-7.94 (m, 1 H).

The synthetic route of 28890-99-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; IDEMITSU KOSAN CO., LTD (IKC); SCHAeFER, Thomas; RAIMANN, Thomas; NAGASHIMA, Hideaki; (108 pag.)WO2016/16791; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

28890-99-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 28890-99-5, name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

250ml four bottles,In the atmosphere of nitrogen gas,0.01 mol of 5H-benzimidazol [1,2-a] benzimidazole was added,0.015 mol of 13- (4-bromophenyl) -10,10-dimethyl-10,13-dihydrobenzofuran [2,3-c] indole [1,2-g] carbazole,0.03 mol of sodium tert-butoxide,1 x 10-4 mol Pd2 (dba) 3,1 x 10-4 mol tri-tert-butylphosphine,150 ml of toluene,Heated to reflux for 24 hours,Sampling point plate, the reaction is complete, natural cooling, filtration, the filtrate steamed, silica gel column, the target product, purity 99.25, yield 49.00%.

The synthetic route of 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jiangsu Sanyue Photoelectric Technology Co., Ltd.; Wang, Lichun; Li, Chong; Xu, Kai; Zhang, Zhaochao; Ye, Zhonghua; (39 pag.)CN106467552; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem