Application of 28890-99-5, These common heterocyclic compound, 28890-99-5, name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[28890-99-5] (3.0 g, 14.4 mmol) is dissolved in THF (0204) (100 ml) and the suspension is cooled to 0 C. NaH as 60% suspension (691 mg, 17.3 mmol) is added in portions. [98-59-9] is dissolved in THF (50 ml) and the solution is dropped into the reaction mixture. It is stirred over night at room temperature. Saturated NH4CI solution (150 ml) is slowly added. It is extracted with ethyl acetate. The crude product is used without further purification.
The synthetic route of 28890-99-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK PATENT GMBH; STENGEL, Ilona; MAIER-FLAIG, Florian; HARBACH, Philipp; MONTENEGRO, Elvira; LUDEMANN, Aurelie; (0 pag.)WO2019/170691; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem