Category: 274-78-2

Amodio, Emanuele published the artcileEffectiveness of mRNA COVID-19 Vaccines in Adolescents Over 6 Months., SDS of cas: 274-78-2, the main research area is .

BACKGROUND AND OBJECTIVES: On June 4, 2021, Italy launched the COVID-19 vaccination of adolescents to pace down the COVID-19 spread. Although clinical trials have evaluated mRNA vaccine effectiveness in adolescents, there is limited literature on its real-world effectiveness. Accordingly, this study aimed to estimate the effectiveness of mRNA COVID-19 vaccines against SARS-CoV-2 infection and mild or severe COVID-19 in a cohort of Sicilian adolescents within a six-month observation period. METHODS: A retrospective cohort study was conducted with adolescents aged 12-18, residents of Sicily, that were followed from July 15 to December 31, 2021. SARS-CoV-2 infections, mild and severe COVID-19, and COVID-19-related intubation or deaths during the study period were compared between subjects vaccinated with two doses of mRNA vaccines and unvaccinated individuals. The Cox regression analysis, adjusted for age and sex, was performed to compare the two groups. RESULTS: Overall, the study included a total at-risk population of 274,782 adolescents with 61.4% (168,633) of them having completed the vaccination cycle by the end of the study. Unvaccinated subjects had higher incidence rates of SARS-CoV-2 (1,043 x 10,000 vs. 158.7 x 10,000 subjects), mild COVID-19 (27.7 x 10,000 vs. 1.8 x 10,000 subjects) and severe COVID-19 (1.41 x 10,000 vs. 0 subjects) compared to the vaccinated population. The estimated adjusted vaccine effectiveness against SARS-CoV-2 infection was 71.2%, reaching 92.1% and 97.9% against mild and severe COVID-19, respectively. CONCLUSIONS: This study provides rigorous evidence of the mRNA COVID-19 vaccines effectiveness in protecting adolescents from both SARS-CoV-2 infection, and mild or severe COVID-19.

Pediatrics published new progress in MEDLINE about 274-78-2, 274-78-2 belongs to class imidazoles-derivatives, name is Imidazo[1,2-c]pyrimidine, and the molecular formula is C6H5N3, SDS of cas: 274-78-2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Milchev, Boyan published the artcileDiet of Barn Owl Tyto alba in central South Bulgaria as influenced by landscape structure, Category: imidazoles-derivatives, the main research area is diet Barn Owl landscape feeding ecol central South Bulgaria.

This study of the diet of Barn Owl Tyto alba analyzed pellets containing 18,810 prey specimens. Small mammals (98.2% by number, 97.5% by biomass) dominated, while birds, reptiles, amphibians, and insects constituted a negligible portion of the diet (1.8% by number, 2.5% by biomass). Voles (Microtus spp.) were the most numerous prey (35.3 ± 14.4%, range 14.6%-67.1%) in 9 localities (69.2%, n = 13 individually studied localities) and dominated the biomass in all diets (51.4 ± 14.1%, range 27.4%-78.2%). The lesser white-toothed shrew (Crocidura suaveolens) (20.8 ± 7.6%, range 7.3%-32.8%) was the most frequent prey in the other 4 localities (30.8%). The breeding localities with more similar proportions of habitats in their hunting territories had significantly higher diet overlaps (r = 0.336, P < 0.01). The amount of wetlands and the indexes of habitat heterogeneity and topog. relief among the landscape characteristics of the hunting territories significantly influenced diet composition according to redundancy anal. Larger areas of wetlands correlated with higher predation on wetland mammal species, as well as the European pine vole (Microtus subterraneus) and white-toothed shrews, and thus with broader food niche breadth. Turkish Journal of Zoology published new progress about Amphibia. 274-78-2 belongs to class imidazoles-derivatives, name is Imidazo[1,2-c]pyrimidine, and the molecular formula is C6H5N3, Category: imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Clark, Jim published the artcileHeterocyclic studies. XVI. Imidazo and diimidazopyrimidines, Quality Control of 274-78-2, the main research area is imidazopyrimidines; diimidazopyrimidines; pyrimidines imidazo.

Condensation of 2,4-dichloro-6-methyl-5-nitropyrimidine (I, X = Cl) with Cl(CH2)2NH2 gave the tetrahydrodiimidazopyrimidine (II). A hydrated derivative (III) of II was prepared by POCl3 treatment of either the 2,4-bis[(2-hydroxyethyl)amino]pyrimidine (I, X = NH(CH2)2OH), the dihydroimidazo[1,2-a]pyrimidine [IV, R1 = Me, R2 = NH(CH2)2OH] or the dihydroimidazo[1,2-a]pyrimidine (V). 4,6-Dichloro-2-methyl-5-nitropyrimidine (VI, X = Cl) and Cl(CH2)2NH2 gave the bis[(2-chloroethyl)amino]-pyrimidine (VI, X = NH(CH2)2Cl), which cyclized in two steps to the dihydroimidazo[1,2-c]pyrimidine [IV, R1 = NH(CH2)2Cl, R2 = Me] and then the quaternary tricyclic compound (VII).

Journal of the Chemical Society [Section] C: Organic published new progress about Cyclization. 274-78-2 belongs to class imidazoles-derivatives, name is Imidazo[1,2-c]pyrimidine, and the molecular formula is C6H5N3, Quality Control of 274-78-2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Armarego, W. L. F. published the artcileTriazaindenes (diazaindolizines). The site of protonation, Application of Imidazo[1,2-c]pyrimidine, the main research area is .

The syntheses of 1,3a,4-, 1,3a,5-, 1,3a,6-, and 1,3a,7-triazaindenes and their 2,3-dihydro derivatives are described. Ionization and uv spectra measurements indicate that in each case protonation occurs on N-1. Evidence is given that 1,2,3a- and 2-methyl-1,3,3a-triazaindene cations are also protonated on N-1, but 1,2,7a-triazaindene cation is protonated on N-2.

Journal of the Chemical Society published new progress about Protonation. 274-78-2 belongs to class imidazoles-derivatives, name is Imidazo[1,2-c]pyrimidine, and the molecular formula is C6H5N3, Application of Imidazo[1,2-c]pyrimidine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Abignente, Enrico published the artcileResearch on heterocyclic compounds. XXVIII. Imidazo[1,2-c]pyrimidines, COA of Formula: C6H5N3, the main research area is imidazopyridine derivative antipyretic antiinflammatory analgesic structure; ulcer formation imidazopyrimidine derivative structure.

A group of 24 imidazo[1,2-c]pyrimidines (I, R1 = CO2H, CO2Et, CONH2, CH2CO2H; R2 = Me, OMe; R3 = OMe, Me, Cl) was taken into consideration to study the relationships between chem. structure and anti-inflammatory activity. Some of these compounds were synthesized by the authors in the past, the others have been synthesized and characterized to complete the series. Anti-inflammatory, analgesic, antipyretic and gastric ulcerogenic activities of such compounds were compared with those of indomethacin and discussed in terms of the effects exerted by the presence on the heterocyclic system of various substituents and an acidic or nonacidic moiety.

Farmaco published new progress about Analgesics. 274-78-2 belongs to class imidazoles-derivatives, name is Imidazo[1,2-c]pyrimidine, and the molecular formula is C6H5N3, COA of Formula: C6H5N3.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cignarella, Giogrio published the artcileBicyclic homologs of piperazine. VII. Synthesis and analgesic activity of 3-aralkenyl-8-propionyl-3,8-diazabicyclo[3.2.1]octanes, Synthetic Route of 274-78-2, the main research area is ANALGESICS AND ANTIPYRETICS; BRIDGED COMPOUNDS; CHEMISTRY, PHARMACEUTICAL; EXPERIMENTAL LAB STUDY; MICE; PHARMACOLOGY; RATS; TOXICOLOGIC REPORT.

cf. CA 59, 11490g, 15283g. With the aim of enhancing the analgesic activity of 3-cinnamyl-8-propionyl-3,8-diazabicyclo[3.2.1] octane (I), 25 derivatives were synthesized in which the 3-aralkenyl group was variously modified. Some of these compounds exhibited an analgesic potency comparable with that of I.

Journal of Medicinal Chemistry published new progress about Analgesics. 274-78-2 belongs to class imidazoles-derivatives, name is Imidazo[1,2-c]pyrimidine, and the molecular formula is C6H5N3, Synthetic Route of 274-78-2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Li, Yuqiang published the artcileEffect of water-containing acetone-butanol-ethanol gasoline blends on combustion, performance, and emissions characteristics of a spark-ignition engine, Related Products of imidazoles-derivatives, the main research area is water acetone butanol ethanol gasoline blend combustion emission engine.

Bio-butanol has proved to be a promising alternative fuel in recent years; it is typically produced from ABE (acetone-butanol-ethanol) fermentation from non-edible biomass feedstock. The high costs for dehydration and recovery from dilute fermentation broth have so far prohibited bio-butanol’s use in internal combustion engines. There is an interesting in studying the intermediate fermentation product, i.e. water-containing ABE as a potential fuel. However, most previous studies covered the use of water-containing ABE-diesel blends. In addition, previous studies on SI engines fueled with ABE did not consider the effect of water. Therefore, the evaluation of water-containing ABE gasoline blends in a port fuel-injected spark-ignition (SI) engine was carried out in this study. Effect of adding ABE and water into gasoline on combustion, performance and emissions characteristics was investigated by testing gasoline, ABE30, ABE85, ABE29.5W0.5 and ABE29W1 (29 volume% ABE, 1 volume% water and 70 volume% gasoline). In addition, ABE29W1 was compared with gasoline under various equivalence ratios (Φ = 0.83-1.25) and engine loads (3 and 5 bar BMEP). It was found that ABE29W1 generally had higher engine toque (3.1-8.2%) and lower CO (9.8-35.1%), UHC (27.4-78.2%) and NOx (4.1-39.4%) than those of gasoline. The study indicated that water-containing ABE could be used in SI engines as an alternative fuel with good engine performance and low emissions.

Energy Conversion and Management published new progress about Combustion. 274-78-2 belongs to class imidazoles-derivatives, name is Imidazo[1,2-c]pyrimidine, and the molecular formula is C6H5N3, Related Products of imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Linz, Sabine published the artcileDesign, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases, Category: imidazoles-derivatives, the main research area is dopamine D4 receptor antagonist Mannich bases SAR preparation.

A series of phenylpiperazine-methyl-substituted 1H-pyrrolo[2,3-c]pyridine, imidazo[1,2-c]-, pyrrolo[2,3-d]- and pyrrolo[3,2-d]pyrimidines were prepared as selective dopamine D4-ligands. The pyrrolo[2,3-d]pyrimidine derivatives 12d (I) (K i = 1,9 nM) and 34d (II)(K i = 2,4 nM) as well as the pyrrolo[3,2-d]pyrimidine Mannich base 49f (III) (K i = 2,8 nM) showed high dopamine D4 receptor activity superior to the atypical antipsychotic agent clozapine.

Bioorganic & Medicinal Chemistry published new progress about Antipsychotics. 274-78-2 belongs to class imidazoles-derivatives, name is Imidazo[1,2-c]pyrimidine, and the molecular formula is C6H5N3, Category: imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Demissie, Taye B. published the artcileMechanism and Site Selectivity in Visible-Light Photocatalyzed C-H Functionalization: Insights from DFT Calculations, Recommanded Product: Imidazo[1,2-c]pyrimidine, the main research area is selectivity visible photocatalyzed carbon hydrogen functionalization DFT.

Visible-light photocatalyzed (VLPC) late-stage C-H functionalization is a powerful addition to the chem. synthesis toolkit. VLPC has a demonstrated potential for discovery of elusive and valuable transformations, particularly in functionalization of bioactive heterocycles. To fully harvest the potential of VLPC in the context of complex mol. synthesis, a thorough understanding of the elementary processes involved is crucial. This would enable more rational design of suitable reagents and catalysts, as well as prediction of activated C-H sites for functionalization. Such knowledge is essential when VLPC is to be employed in retrosynthetic anal. of complex mols. Herein, the authors present a d. functional theory (DFT) study of mechanistic details in the C-H functionalization of bioactive heterocycles exemplified by the methylation of the antifungal agent voriconazole. Also, readily computed at. charges can predict major site-selectivity in good agreement with exptl. studies and thus be informative tools for the identification of active C-H functionalization sites in synthetic planning.

Journal of Organic Chemistry published new progress about C-C bond cleavage. 274-78-2 belongs to class imidazoles-derivatives, name is Imidazo[1,2-c]pyrimidine, and the molecular formula is C6H5N3, Recommanded Product: Imidazo[1,2-c]pyrimidine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Galasso, Vinicio published the artcileElectronic structure and absorption spectra of indolizines, Product Details of C6H5N3, the main research area is INDOLIZINES SPECTRA.

The electronic structure and spectra of indolizine and a large number of its aza-derivatives have been calculated by the S.C.F.M.O.-C.I. method, taking into account all the singlet monoexcited configurations. The results are in good agreement with the experiment The assignment of the observed bands is also discussed. 17 references.

Theoretica Chimica Acta published new progress about Electron configuration. 274-78-2 belongs to class imidazoles-derivatives, name is Imidazo[1,2-c]pyrimidine, and the molecular formula is C6H5N3, Product Details of C6H5N3.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem