Category: 2735-62-8

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2735-62-8 as follows. category: imidazoles-derivatives

General procedure: 2-(1-Methyl-1H-benzo[d]imidazol-2-yl)acetonitrile (171 mg, 1.0 mmol), t-BuOK (112 mg, 1.0 mmol), and dry THF (5 mL) were stirred for 30 min at room temperature. To the resulting mixture 3-(phenylethynyl)quinoxaline-2-carbonitrile 1a (128 mg, 0.5 mmol) was added by portions. The reaction mixture was stirred for 48 h at room temperature and then evaporated to dryness without heating. The residue was treated with some drops of acetic acid. After evaporation it was mixed with silica gel and purified by flash column chromatography on silica gel (2.5×40 cm) with CHCl3 as the eluent. The first fraction recovered was 1a (32 mg, 25%). The orange fraction was collected and purified additionally by flash column chromatography on Al2O3 (2.5×20 cm) with CHCl3 as the eluent. The orange red fraction with Rf 0.65 gave 5e (48 mg, 24%).

According to the analysis of related databases, 2735-62-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Nguyen, Huong T.L.; Gulevskaya, Anna V.; Pozharskii, Alexander F.; Nelina-Nemtseva, Julia I.; Tetrahedron; vol. 70; 31; (2014); p. 4617 – 4625;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 2735-62-8, These common heterocyclic compound, 2735-62-8, name is 2-(1-Methyl-1H-benzo[d]imidazol-2-yl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of nitrile (33a, b, 36a-f, i) (1.0mmol) in pyridine (2.5mL) was added 2-mercaptoacetic acid or 37a-c (1.0mmol), and the mixture was stirred at reflux for 8h. After addition of H2O (10mL), the mixture was extracted with EtOAc (3×10mL) and the combined organic layers were washed with brine (30mL) and dried (MgSO4). Evaporation of the solvent followed by chromatography (hexane-EtOAc, 1:1) of the residue gave thiazole (5, 6, 10, 14, 16-20 and 24).

The synthetic route of 2735-62-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Sogame, Shinya; Suenaga, Yoshihito; Atobe, Masakazu; Kawanishi, Masashi; Tanaka, Eiichi; Miyoshi, Shiro; European Journal of Medicinal Chemistry; vol. 71; (2014); p. 250 – 258;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2735-62-8, name is 2-(1-Methyl-1H-benzo[d]imidazol-2-yl)acetonitrile belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C10H9N3

General procedure: To a solution of substituted acetonitriles (12 mmol) in MeOH (25 mL) was added triethylamine (12 mmol) and aldehydes (12 mmol). The mixture was stirred at 50 C, after the reaction was complete (typically 1-3 h). The reaction mixture was cooled to room temperature, the precipitate was isolated by filtration and washed with cold MeOH (2 * 1 mL) to give the desired products.

The synthetic route of 2735-62-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Huijie; Lv, Kaikai; Ma, Lanping; Zhang, Yongliang; Yu, Ting; Chen, Lin; Wang, Xin; Shen, Jingkang; Meng, Tao; Tetrahedron Letters; vol. 61; 23; (2020);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 2735-62-8,Some common heterocyclic compound, 2735-62-8, name is 2-(1-Methyl-1H-benzo[d]imidazol-2-yl)acetonitrile, molecular formula is C10H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-(1-Methyl-1H-benzo[d]imidazol-2-yl)acetonitrile (171 mg, 1.0 mmol), t-BuOK (112 mg, 1.0 mmol), and dry THF (5 mL) were stirred for 30 min at room temperature. To the resulting mixture 3-(phenylethynyl)quinoxaline-2-carbonitrile 1a (128 mg, 0.5 mmol) was added by portions. The reaction mixture was stirred for 48 h at room temperature and then evaporated to dryness without heating. The residue was treated with some drops of acetic acid. After evaporation it was mixed with silica gel and purified by flash column chromatography on silica gel (2.5¡Á40 cm) with CHCl3 as the eluent. The first fraction recovered was 1a (32 mg, 25%). The orange fraction was collected and purified additionally by flash column chromatography on Al2O3 (2.5¡Á20 cm) with CHCl3 as the eluent. The orange red fraction with Rf 0.65 gave 5e (48 mg, 24%).

The synthetic route of 2735-62-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Nguyen, Huong T.L.; Gulevskaya, Anna V.; Pozharskii, Alexander F.; Nelina-Nemtseva, Julia I.; Tetrahedron; vol. 70; 31; (2014); p. 4617 – 4625;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 2735-62-8, These common heterocyclic compound, 2735-62-8, name is 2-(1-Methyl-1H-benzo[d]imidazol-2-yl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 1-methyl-1H benzoimidazol-2-yl)-acetonitrile (4)(23 mg, 0.13 mmol) and 4-methoxy-2-vinyloxy-benzaldehyde (3)(24 mg, 0.13 mmol) in ethanol (4 mL) were treated with one drop ofpiperidine at RT. The solution was stirred for 1 h. No starting wasleft in TLC. The reaction mixture was evaporated. The obtainedcrude mass was purified by column chromatography on silica,product eluted with 10-15% ethyl acetate in hexane to afford 3-(4-methoxy-2-vinyloxy-phenyl)-2-(1-methyl-1H-benzoimidazol-2-yl)-acrylonitrile(VPBA) (20 mg, 44.8%) as yellow solid. 1HNMR(400 MHz, CDCl3): delta (ppm) = 8.39-8.35 (m, 2H), 7.78 (d, J = 7.8 Hz,1H), 7.38-7.30 (m, 3H), 6.75 (d, J = 8.8 Hz, 1H), 6.60-6.56 (m, 2H),4.87 (d, J = 13.64 Hz, 1H), 4.58 (d, J = 5.76 Hz, 1H), 3.99 (s, 3H), 3.87(s, 3H). 13C NMR (100 MHz, CDCl3): 164.03, 157.61, 148.34, 146.96,145.08, 142.46, 136.71, 129.98, 123.58, 122.97, 119.95, 117.32, 115.98,109.68, 108.89, 102.37, 98.23, 97.37, 55.77, 31.63. MS (ESI): m/z calc.for C20H17N3O2: 331.13; found: 332.14 [M + H]+.

The synthetic route of 2735-62-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Manna, Srimanta; Karmakar, Parthasarathi; Maiti, Kalipada; Ali, Syed Samim; Mandal, Debasish; Mahapatra, Ajit Kumar; Journal of Photochemistry and Photobiology A: Chemistry; vol. 343; (2017); p. 7 – 16;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem