Category: 26832-08-6

Ribosidation of 4-amino-5-imidazolecarboxamide by Escherichia coli was written by Ben-Ishai, R.;Bergmann, Ernst D.;Volcani, B. E.. And the article was included in Nature (London, United Kingdom) in 1951.Related Products of 26832-08-6 This article mentions the following:

Evidence is presented for the conversion of 4-amino-5-imidazolecarboxamide (I) by E. coli into a glycoside. The supernatant from a cell suspension of E. coli B, incubated with the hydrochloride of I in 0.066 M phosphate buffer, contained a growth-enhancing component for a purine-requiring E. coli mutant, which was more effective than I. The supernatant was lyophilized, concentrated, chromatographed on paper with 5% KH₂PO₄ in iso-AmOH, and developed by diazotization. Two distinct spots were obtained; R_f for the unknown was 0.63, and for the HCl of I 0.68. A pos. orcinol test and a color reaction with diphenylamine, exceeding that for the blank, indicated the presence of desoxyribose. The ultraviolet spectrum for the unknown had an absorption maximum at 2600 A. The ultraviolet maximum for the hydrochloride of I was 2680 A. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Related Products of 26832-08-6).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Related Products of 26832-08-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Manganese-zeolitic imidazolate frameworks-90 with high blood circulation stability for MRI-guided tumor therapy was written by Jiang, Zhenqi;Yuan, Bo;Qiu, Nianxiang;Wang, Yinjie;Sun, Li;Wei, Zhenni;Li, Yanyin;Zheng, Jianjun;Jin, Yinhua;Li, Yong;Du, Shiyu;Li, Juan;Wu, Aiguo. And the article was included in Nano-Micro Letters in 2019.Recommanded Product: 1H-Imidazole-4-carboxamide This article mentions the following:

Zeolitic imidazolate frameworks (ZIFs) as smart drug delivery systems with microenvironment-triggered release have attracted much attention for tumor therapy. However, the exploration of ZIFs in biomedicine still encounters many issues, such as inconvenient surface modification, fast drug release during blood circulation, undesired damage to major organs, and severe in vivo toxicity. To address the above issues, we developed an Mn-ZIF-90 nanosystem functionalized with an originally designed active-targeting and pH-responsive magnetic resonance imaging (MRI) Y₁ receptor ligand [Asn²⁸, Pro³⁰, Trp³²]-NPY (25-36) for imaging-guided tumor therapy. After Y₁ receptor ligand modification, the Mn-ZIF-90 nanosystem exhibited high drug loading, better blood circulation stability, and dual breast cancer cell membrane and mitochondria targetability, further favoring specific microenvironment-triggered tumor therapy. Meanwhile, this nanosystem showed promising T1-weighted magnetic resonance imaging contrast in vivo in the tumor sites. Especially, this nanosystem with fast clean-up had almost no obvious toxicity and no damage occurred to the major organs in mice. Therefore, this nanosystem shows potential for use in imaging-guided tumor therapy. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Recommanded Product: 1H-Imidazole-4-carboxamide).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Recommanded Product: 1H-Imidazole-4-carboxamide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Pharmacokinetic results of a phase I trial of sorafenib in combination with dacarbazine in patients with advanced solid tumors was written by Brendel, Erich;Ludwig, Matthias;Lathia, Chetan;Robert, Caroline;Ropert, Stanislas;Soria, Jean-Charles;Armand, Jean-Pierre. And the article was included in Cancer Chemotherapy and Pharmacology in 2011.Name: 1H-Imidazole-4-carboxamide This article mentions the following:

Sorafenib, a multikinase inhibitor of Raf and several growth factor receptors, is under investigation in combination with dacarbazine, a commonly used chemotherapeutic agent for the treatment of many cancers. The current phase I study investigates the effects of sorafenib on the pharmacokinetic (PK) profile of dacarbazine and its metabolite 5-amino-imidazole-4-carboxamide (AIC). AIC is formed in amounts equimolar to the active alkylating moiety, methane diazohydroxide, which is undetectable by known validated assays. Patients with advanced solid tumors received i.v. dacarbazine 1000 mg/m² on day 1 of a 21-day cycle to evaluate the PK of dacarbazine alone. Sorafenib 400 mg was administered twice daily continuously starting at day 2 of cycle 1. The PK of dacarbazine in the presence of sorafenib was assessed on day 1 of cycle 2. Sorafenib PK was also assessed at steady state. PK data were available for 15 of 23 patients. With concomitant administration of sorafenib, the mean AUC and C _max values of dacarbazine were reduced by 23% and 16%, resp. Mean AUC and C _max values of AIC were increased by 41% and 45%, resp., with individual increases of up to 106% and 136%, resp. The apparent terminal half-lives of the two compounds were not significantly influenced by sorafenib. Based on coefficients of variation, the AUC and C _max values for sorafenib and its three metabolites were highly variable with dacarbazine coadministration. Concomitant administration of sorafenib and dacarbazine as described above may result in decreased dacarbazine exposure but increased AIC exposure. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Name: 1H-Imidazole-4-carboxamide).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Name: 1H-Imidazole-4-carboxamide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-喂 was written by Sajan, Mini P.;Nimal, Sonali;Mastorides, Stephen;Acevedo-Duncan, Mildred;Kahn, C. Ronald;Fields, Alan P.;Braun, Ursula;Leitges, Michael;Farese, Robert V.. And the article was included in Metabolism, Clinical and Experimental in 2012.HPLC of Formula: 26832-08-6 This article mentions the following:

Excessive activity of hepatic atypical protein kinase (aPKC) is proposed to play a critical role in mediating lipid and carbohydrate abnormalities in obesity, the metabolic syndrome, and type 2 diabetes mellitus. In previous studies of rodent models of obesity and type 2 diabetes mellitus, adenoviral-mediated expression of kinase-inactive aPKC rapidly reversed or markedly improved most if not all metabolic abnormalities. Here, we examined effects of 2 newly developed small-mol. PKC-喂/位 inhibitors. We used the mouse model of heterozygous muscle-specific knockout of PKC-位, in which partial deficiency of muscle PKC-位 impairs glucose transport in muscle and thereby causes glucose intolerance and hyperinsulinemia, which, via hepatic aPKC activation, leads to abdominal obesity, hepatosteatosis, hypertriglyceridemia, and hypercholesterolemia. One inhibitor, 1H-imidazole-4-carboxamide, 5-amino-1-[2,3-dihydroxy-4-[(phosphonooxy)methyl]cyclopentyl-[1R-(1a,2b,3b,4a)]], binds to the substrate-binding site of PKC-位/喂, but not other PKCs. The other inhibitor, aurothiomalate, binds to cysteine residues in the PB1-binding domains of aPKC-位/喂/味 and inhibits scaffolding. Treatment with either inhibitor for 7 days inhibited aPKC, but not Akt, in liver and concomitantly improved insulin signaling to Akt and aPKC in muscle and adipocytes. Moreover, both inhibitors diminished excessive expression of hepatic, aPKC-dependent lipogenic, proinflammatory, and gluconeogenic factors; and this was accompanied by reversal or marked improvements in hyperglycemia, hyperinsulinemia, abdominal obesity, hepatosteatosis, hypertriglyceridemia, and hypercholesterolemia. Our findings highlight the pathogenetic importance of insulin signaling to hepatic PKC-喂 in obesity, the metabolic syndrome, and type 2 diabetes mellitus and suggest that 1H-imidazole-4-carboxamide, 5-amino-1-[2,3-dihydroxy-4-[(phosphonooxy)methyl]cyclopentyl-[1R-(1a,2b,3b,4a)]] and aurothiomalate or similar agents that selectively inhibit hepatic aPKC may be useful treatments. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6HPLC of Formula: 26832-08-6).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.HPLC of Formula: 26832-08-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Probing the cannabinoid CB₁/CB₂ receptor subtype selectivity limits of 1,2-diarylimidazole-4-carboxamides by fine-tuning their 5-substitution pattern was written by Lange, Jos H. M.;van der Neut, Martina A. W.;Borst, Alice J. M.;Yildirim, Mahmut;van Stuivenberg, Herman H.;van Vliet, Bernard J.;Kruse, Chris G.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Recommanded Product: 1H-Imidazole-4-carboxamide This article mentions the following:

The cannabinoid CB₁/CB₂ receptor subtype selectivity in the 1,2-diarylimidazole-4-carboxamide series was boosted by fine-tuning its 5-substitution pattern. The presence of the 5-methylsulfonyl group in 11 led to a greater than 鈭?40-fold CB₁/CB₂ subtype selectivity. The compounds 10, 18 and 19 were found more active than rimonabant (1) in a CB₁-mediated rodent hypotension model after oral administration. Our findings suggest a limited brain exposure of the P-glycoprotein substrates 11, 12 and 21. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Recommanded Product: 1H-Imidazole-4-carboxamide).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Recommanded Product: 1H-Imidazole-4-carboxamide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis and evaluation of 2-(4-[4-acetylpiperazine-1-carbonyl] phenyl)-1H-benzo[d]imidazole-4-carboxamide derivatives as potential PARP-1 inhibitors and preliminary study on structure-activity relationship was written by Chen, Miaojia;Huang, Honglin;Wu, Kaiyue;Liu, Yunfan;Jiang, Lizhi;Li, Yang;Tang, Guotao;Peng, Junmei;Cao, Xuan. And the article was included in Drug Development Research in 2022.Category: imidazoles-derivatives This article mentions the following:

A series of 2-(4-[4-substitutedpiperazine-1-carbonyl]phenyl)-1H-benzo[d]imidazole-4-carboxamide derivatives I [R = Me, Ph, 2-furyl, etc.] was designed, synthesized and successful characterization as novel and effective poly ADP-ribose polymerases (PARP)-1 inhibitors to improve the structure-activity relationships about the substituents in the hydrophobic pocket. These derivatives were evaluated for their PARP-1 inhibitory activity and cellular inhibitory against BRCA-1 deficient cells (MDA-MB-436) and wild cells (MCF-7) using PARP kit assay and MTT method. The results indicated that compared with other heterocyclic compounds, furan ring-substituted derivatives I [R = 2-furyl, 3-methyl-2-furyl, 5-bromo-2-furyl, 5-chloro-2-furyl] showed better PARP-1 inhibitory activity. Among this derivatives, compound I [R = 5-bromo-2-furyl] displayed the strongest inhibitory effects on PARP-1 enzyme (IC₅₀ = 0.023渭M), which was close to that of Olaparib. The compounds I [R = 5-bromo-2-furyl] (IC₅₀ = 43.56 卤 0.69渭M) and I [R = 5-chloro-2-furyl] (IC₅₀ = 36.69 卤 0.83渭M) displayed good antiproliferation activity on MDA-MB-436 cells and inactivity on MCF-7 cells, indicating that they had high selectivity and targeting. The mol. docking method was used to explore the binding mode of compound I [R = 5-bromo-2-furyl] and PARP-1, and implied that the formation of hydrogen bond was essential for PARP-1 inhibition activities. This study also showed that in the hydrophobic pocket (AD binding sites), the introduction of strong electroneg. groups (furan ring, e.g.) or halogen atoms in the side chain of benzimidazole might improve its inhibitory activity and this strategy could be applied in further research. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Category: imidazoles-derivatives).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Vascular action of some imidazoles was written by Loeper, M.;Mougeot, A.;Aubertot, R.. And the article was included in Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales in 1934.SDS of cas: 26832-08-6 This article mentions the following:

The action of 4-methylimidazole, 4-methoxyimidazole, imidazole-4-formamide and diarabinotetrahydroxybutylimidazole on snail hearts, isolated arteries and live dogs was studied. The first 2 are hypertensive. Similar experiments by others with various imidazole derivatives are reviewed. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6SDS of cas: 26832-08-6).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.SDS of cas: 26832-08-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Disclosure of mystery of “fairy rings” by chemistry was written by Kawagishi, Hirokazu. And the article was included in Yuki Gosei Kagaku Kyokaishi in 2015.Reference of 26832-08-6 This article mentions the following:

A review on chems. responsible for “fairy rings” of turf grass, their formation through a new purine metabolic pathway, and chem. synthesis of ¹³C,¹⁵N-labeled metabolites. 2-Azahypoxanthine (AHK, I) (rice plant-growth promotor) and imidazole-4-carboxamide (ICA, II) (turf grass growth inhibitor) were isolated from a fairy-ring forming fungus Lepista sordida. AHK was converted into a metabolite, 2-aza-8-oxohypoxanthine (AOH, III) (turf grass growth-promoters), in plants. Afterward, it turned out that these three compounds, fairy chems. (FSc), endogenously exist in plants and are biosynthesized via a new purine metabolic pathway. Furthermore, FCs increased the yields of rice, wheat and other crops in the field experiments In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Reference of 26832-08-6).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Reference of 26832-08-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Valorization of Sugar Beet Pulp via Torrefaction with a Focus on the Effect of the Preliminary Extraction of Pectins was written by Brachi, Paola;Riianova, Evelina;Miccio, Michele;Miccio, Francesco;Ruoppolo, Giovanna;Chirone, Riccardo. And the article was included in Energy & Fuels in 2017.Synthetic Route of C4H5N3O This article mentions the following:

An agro-industrial residue, i.e., sugar beet pulp, was taken into consideration in this work as a feedstock for valorization as a solid fuel and, potentially, as a source of valuable biochems. obtainable from the torgas condensable fraction. To this end, an exptl. program based on torrefaction of such a residue after pectin extraction (PE-SBP) was performed. The alternative scenario of raw sugar beet pulp (raw-SBP) torrefaction was also investigated for comparison. Raw biomasses and torrefaction products were analyzed by different techniques including thermogravimetric anal. and derivative thermogravimetry (TGA-DTG), Fourier transform IR spectroscopy (FTIR), gas chromatrog. coupled to mass spectrometry (GC/MS), and proximate and ultimate analyses. This allowed the comparative investigation of the role played by the pectin extraction method and the torrefaction temperature on the process performance and main properties of the resulting solid products. Outcomes showed that light torrefaction (200-240 掳C) is a suitable and more energy-efficient process for production of high quality solid fuels from SBP. Moreover, it resulted that PE-SBP is better than raw-SBP as a feedstock due to its lower nitrogen and ash content. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Synthetic Route of C4H5N3O).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Synthetic Route of C4H5N3O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chemical Fragments that Hydrogen Bond to Asp, Glu, Arg, and His Side Chains in Protein Binding Sites was written by Chan, A. W. Edith;Laskowski, Roman A.;Selwood, David L.. And the article was included in Journal of Medicinal Chemistry in 2010.Recommanded Product: 26832-08-6 This article mentions the following:

We present an anal. of the chem. fragments from lead-like ligands in the Protein Data Bank (PDB) that form hydrogen bonds to the side chains of Asp, Glu, Arg, and His, which are the most common residues found in ligand binding sites. A fragment is defined as the largest ring assembly containing the atoms involved in hydrogen bonding. In total, 462 fragments were found in 2038 ligands from over 8000 protein-ligand structures in the PDB. The results show which fragments have a higher propensity for interaction with specific side chains. Some fragments interact with Asp but not with Glu, and vice versa, despite these side chains sharing the same chem. moiety. Arg side chains form hydrogen bonds almost exclusively with O-mediated ligands, and the fragments are the most diverse. Hydrogen bond distances from the imidazole of His showed a wider range than the other three amino acids. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Recommanded Product: 26832-08-6).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 26832-08-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem