Category: 2625-49-2

Adding a certain compound to certain chemical reactions, such as: 2625-49-2, name is 2-(1-Methyl-1H-imidazol-4-yl)acetic acid, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2625-49-2, COA of Formula: C6H8N2O2

EXAMPLE 53A {4-[4-(1-Methylimidazol-4-yl)-3-keto-1-butynyl]-2-phenylbenzoyl}-methionine methyl ester To a solution of 1-methyl-4-imidazoleacetic acid (5 mmol) in methylene chloride at 0 C. is added oxalyl chloride (6 mmol) and DMF (0.05 mmol). After 30 minute, the solvent is evaporated in vacuo. The residue is redissolved in dichloromethane, followed by the addition of the resultant acetylene from Example 47A (5 mmol), triethylamine (10 mmol), and copper(I) iodide (1 mmol). The reaction is stirred at 25 C. until TLC analysis indicates no starting material is left in the reaction mixture. The reaction is diluted with ether, washed with water and brine, dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo. The residue is then purified by column chromatography on silica gel to give the title compound.

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Reference:
Patent; University of Pittsburgh; US6310095; (2001); B1;; ; Patent; University of Pittsburgh; US2002/193596; (2002); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

2625-49-2, A common heterocyclic compound, 2625-49-2, name is 2-(1-Methyl-1H-imidazol-4-yl)acetic acid, molecular formula is C6H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a mixture of 2-amino-5-(4-methylphenyl) thiophene-3-carboxamide 1a (0.25 g, 0.107 mol) and 4-benzyloxy benzoic acid 4a (0.319 g, 0.140 mol) in anhydrous chloroform (4 ml) was added triethylamine (0.32 g, 0.323 mol) and phosphonic acid cyclic anhydride (1.02 g, 0.323 mol). The reaction mixture was irradiated at 120 C in a microwave initiator for a given period of time (Table 1, entry 1). Once the substrate was completely consumed as monitored by TLC, the brown reaction mixture was cooled and poured into ice-cold water (10 ml). The product was extracted with ethyl acetate (2 ¡Á 25 ml) and the combined organic phase was washed with water, brine solution and dried over anhydrous sodium sulfite. The solvent was removed under vacuum and the brown residue was passed through a small plug of silica gel using petroleum ether/ethyl acetate (9/1) to afford 429 mg (94%) of 2a as a yellow solid.

The synthetic route of 2625-49-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Poojari, Subba; Parameswar Naik; Krishnamurthy; Tetrahedron Letters; vol. 53; 35; (2012); p. 4639 – 4643;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem