Category: 258278-25-0

Wei, Yi-Ming published the artcileIron-catalyzed stereospecific arylation of enol tosylates using Grignard reagents, Related Products of imidazoles-derivatives, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(7), 1101-1104, database is CAplus and MEDLINE.

The stereospecific Fe-catalyzed arylation of enol tosylates with Grignard reagents was reported for the synthesis of Z- and E- tri/tetrasubstituted acrylates (Ar)(R)C=C(CO₂R¹)(R²) [R = Me, i-Pr, Ph, etc.; R¹ = Me, Et; R² = H, Me, Ph; Ar = Ph, 2-CNC₆H₄, 2-thienyl, etc.]. Various tri- or tetrasubstituted Z or E-enol tosylates of β-keto esters were arylated using common and Knochel-type Grignard reagents with complete stereofidelity. The precursors for Z/E-zimelidine, tamoxifen and other bioactive compounds were facilely prepared without precious and toxic transition metals.

Chemical Communications (Cambridge, United Kingdom) published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C39H35N5O8, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ariki, Zachary T. published the artcilePreparation of Quaternary Centers via Nickel-Catalyzed Suzuki-Miyaura Cross-Coupling of Tertiary Sulfones, Category: imidazoles-derivatives, the publication is Journal of the American Chemical Society (2018), 140(1), 78-81, database is CAplus and MEDLINE.

We describe the development of a nickel-catalyzed Suzuki-Miyaura cross-coupling of tertiary benzylic and allylic sulfones with arylboroxines. A variety of tertiary sulfones, which can easily be prepared via a deprotonation-alkylation route, were reacted to afford sym. and unsym. quaternary products in good yields. We highlight the use of either BrettPhos or Doyle’s phosphines as effective ligands for these challenging desulfonative coupling reactions. The utility of this methodol. was demonstrated in the concise synthesis of a vitamin D receptor modulator analog.

Journal of the American Chemical Society published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sioriki, Eleni published the artcileIn vitro Anti-atherogenic Properties of N-Heterocyclic Carbene Aurate(I) Compounds, Product Details of C27H39ClN2, the publication is ChemMedChem (2018), 13(23), 2484-2487, database is CAplus and MEDLINE.

The anti-atherogenic (anti-inflammatory) properties of various aurate(I) salts, of the general formula [NHC·H][AuCl₂] (NHC=N-heterocyclic carbene) were investigated. The aurates were easily synthesized and obtained in anal. pure form. In addition, the biol. activity of these compounds against atheromatosis via in vitro inhibition of platelet-activating factor (PAF)-induced platelet aggregation was probed. All complexes were found to possess anti-aggregatory properties in vitro with [IPr*·H][AuCl₂] (6) being the most potent inhibitor of PAF at micromolar concentration Based on our findings, we conclude that these simply assembled aurates are a very promising class of PAF inhibitors and anti-inflammatory drugs.

ChemMedChem published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C9H13NO2, Product Details of C27H39ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Gu, Yang published the artcileLigand-Controlled Copper-Catalyzed Highly Regioselective Difluoromethylation of Allylic Chlorides/Bromides and Propargyl Bromides, Product Details of C27H39ClN2, the publication is Chinese Journal of Chemistry (2018), 36(1), 55-58, database is CAplus.

Highly regiodivergent copper-catalyzed allylic/propargylic difluoromethylation reactions by employing different ligands were described. When 5,6-dimethyl-1,10-phenanthroline was used as the ligand, exclusively α-difluoromethylated products I [R = 4-ClC₆H₄, 4-CF₃C₆H₄, 1-naphthyl, etc.] were obtained, while γ-selective difluoromethylated products II were generated when N-heterocyclic carbene-SIPr was used as the ligand. Likewise, α-difluoromethylated products III [Ar = 4-ClC₆H₄, 4-CF₃C₆H₄, 4-t-BuC₆H₄, etc.] and γ-difluoromethylated products IV were achieved in the presence of similar copper catalysts for the reactions of propargyl bromides. Moreover, a copper-catalyzed asym. allylic difluoromethylation reaction with moderate to good enantioselectivity by the use of chiral ligands was afforded α-difluoromethylated products II [R = 3-ClC₆H₄, 4-CO₂MeC₆H₄, 2,5-(Br)₂C₆H₃, etc.].

Chinese Journal of Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Product Details of C27H39ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Jiang, Cheng published the artcileNi-Catalyzed 1,2-Acyl Migration Reactions Triggered by C-C Bond Activation of Ketones, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is ACS Catalysis (2020), 10(3), 1947-1953, database is CAplus.

A Ni-catalyzed 1,2-acyl migration triggered by C-C bond cleavage was developed. The process of 1,2-acyl migration followed by olefin isomerization provides a convenient access to α,β-unsaturated ketones, which are well-known building blocks in organic synthesis. Exptl. and computational studies show that the selective β-hydride elimination and Ni-hydride reinsertion play an essential role in this reaction.

ACS Catalysis published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Han, Bo published the artcileChromium- and Cobalt-Catalyzed, Regiocontrolled Hydrogenation of Polycyclic Aromatic Hydrocarbons: A Combined Experimental and Theoretical Study, Computed Properties of 258278-25-0, the publication is Journal of the American Chemical Society (2019), 141(22), 9018-9026, database is CAplus and MEDLINE.

Polycyclic aromatic hydrocarbons are difficult substrates for hydrogenation because of the thermodn. stability caused by aromaticity. We report here the first chromium- and cobalt-catalyzed, regiocontrolled hydrogenation of polycyclic aromatic hydrocarbons at ambient temperature These reactions were promoted by low-cost chromium or cobalt salts combined with diimino/carbene ligand and methylmagnesium bromide and are characterized by high regioselectivity and expanded substrate scope that includes tetracene, tetraphene, pentacene, and perylene, which have rarely been reduced. The approach provides a cost-effective catalytic protocol for hydrogenation, is scalable, and can be utilized in the synthesis of tetrabromo- and carboxyl-substituted motifs through functionalization of the hydrogenation product. The systematic theor. mechanistic modelings suggest that low-valent Cr and Co monohydride species, most likely from zerovalent transition metals, are capable of mediating these hydrogenations of fused PAHs.

Journal of the American Chemical Society published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Computed Properties of 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Tran, Van T. published the artcileNi(COD)(DQ): An Air-Stable 18-Electron Nickel(0)-Olefin Precatalyst, Formula: C27H39ClN2, the publication is Angewandte Chemie, International Edition (2020), 59(19), 7409-7413, database is CAplus and MEDLINE.

We report that Ni(COD)(DQ) (COD = 1,5-cyclooctadiene, DQ = duroquinone), an air-stable 18-electron complex originally described by Schrauzer in 1962, is a competent precatalyst for a variety of nickel-catalyzed synthetic methods from the literature. Due to its apparent stability, use of Ni(COD)(DQ) as a precatalyst allows reactions to be conveniently performed without use of an inert-atm. glovebox, as demonstrated across several case studies.

Angewandte Chemie, International Edition published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C14H10O4, Formula: C27H39ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wei, Kaijie published the artcileIron-Catalyzed 1,4-Phenyl Migration/Ring Expansion of α-Azido N-Phenyl Amides, Name: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is Organic Letters (2021), 23(21), 8650-8654, database is CAplus and MEDLINE.

A novel iron-catalyzed skeleton rearrangement of alkyl azides was reported. Upon treatment with FeCl₂ and N-heterocyclic carbene S_IPr·HCl in the presence of H₂O and Et₃N, 2-azido-N,N-diphenylamides underwent 1,4-Ph migration and ring expansion to give azepin-2-ones in good yield. The reaction proceeds via intramol. nitrene cycloaddition followed by C-N cleavage, water addition, and electrocyclic ring opening.

Organic Letters published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C18H10F3NO3S2, Name: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhou, Tongliang published the artcile[Pd(NHC)(acac)Cl]: Well-Defined, Air-Stable, and Readily Available Precatalysts for Suzuki and Buchwald-Hartwig Cross-coupling (Transamidation) of Amides and Esters by N-C/O-C Activation, Quality Control of 258278-25-0, the publication is Organic Letters (2019), 21(9), 3304-3309, database is CAplus and MEDLINE.

A general class of well-defined, air-stable, and readily available Pd(II)-NHC precatalysts (NHC = N-heterocyclic carbene) for Suzuki and Buchwald-Hartwig cross-coupling of amides (transamidation) and esters by selective N-C/O-C cleavage is reported. Since these precatalysts are highly active and the easiest to synthesize, the study clearly suggests that [Pd(NHC)(acac)Cl] should be routinely included during the development of new cross-coupling methods. An assay for in situ screening of NHC salts in this cross-coupling manifold is presented.

Organic Letters published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C18H23N3O4S, Quality Control of 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Yao, Wei-Wei published the artcileNi-catalyzed hydroaminoalkylation of alkynes with amines, Name: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is Nature Communications (2021), 12(1), 3800, database is CAplus and MEDLINE.

Here, a late transition metal Ni-catalyzed hydroaminoalkylation of alkynes RCCR¹ (R = Me, n-Bu, Ph, 4-methoxyphenyl, etc.; R¹ = Me, i-Pr, TMS, 4-ethylphenyl, etc.) with N-sulfonyl amines R²CH₂NHR³ (R² = pentyl, cyclohexyl, Ph, thiophen-2-yl, 2H-1,3-benzodioxol-5-yl, etc.; R³ = Ms, Ts, [2,4,6-tris(propan-2-yl)phenyl]sulfonyl, etc.), providing a series of allylic amines R²CH(NHR³)C(=CHR¹)(R) in up to 94% yield was reported. Double ligands of N-heterocyclic carbene (IPr) and tricyclohexylphosphine (PCy₃) effectively promote the reaction.

Nature Communications published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C5H11NO2S, Name: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem