Category: 25676-75-9

25676-75-9, Name is 4-Bromo-1-methylimidazole, molecular formula is C4H5BrN2, HPLC of Formula: C4H5BrN2, belongs to imidazoles-derivatives compound, is a common compound. In a patnet, author is Vlaicu, Ioana Dorina, once mentioned the new application about 25676-75-9.

Thermal, spectral and biological investigation of new nickel complexes with imidazole derivatives

Four new Ni(II) complexes with acrylate and imidazole (Him) or imidazole derivatives [2-methylimidazole(2-MeIm)/5-methylimidazole(5-MeIm)/2-ethylimidazole(2-EtIm)] as ligands were prepared and characterized. All coordination compounds were characterized by elemental analysis, infrared (FTIR) and ultraviolet-visible-near-infrared (UV-Vis-NIR) spectroscopy, mass spectroscopy, magnetic moments measurements and thermal analysis (TG). The resulted complexes were formulated as follows: [Ni(HIm)(2)(acr)(2)] (1), [Ni(2-MeIm)(2)(acr)(2)(H2O)] center dot H2O (2), [Ni(5-MeIm)(2)(acr)(2)]center dot H2O. (3), [Ni(2-EtIm)(2)(acr)(2)(H2O)] center dot H2O (4). On the basis of magnetic moments measurements and on UV-Vis-NIR spectra, for all Ni(II) complexes was proposed an octahedral stereochemistry. Acrylate ions act as bidentate in complexes (1) and (3); meanwhile, in (2) and (4) they behave as bidentate and unidentate. Antimicrobial activity of complexes was investigated on ATCC reference and clinical microbial strains. The MIC (minimum inhibitory concentration) values revealed moderate antimicrobial activity of complex (1) against Enterococcus faecium and of complex (2) against Pseudomonas aeruginosa and Bacillus subtilis.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 25676-75-9 help many people in the next few years. HPLC of Formula: C4H5BrN2.

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 25676-75-9, Name is 4-Bromo-1-methylimidazole, molecular formula is C4H5BrN2, belongs to imidazoles-derivatives compound. In a document, author is Scott, J, introduce the new discover, COA of Formula: C4H5BrN2.

Novel chromogenic, guest-sensitive host compounds

A series of novel chromogenic host compounds based on a diphenylazo core with bulky endgroups and hydrogen bonding capability has been synthesised and shown to exhibit distinct and easily detected colour changes on complexation with guests, allowing for rapid screening of host: guest complex formation.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 25676-75-9. COA of Formula: C4H5BrN2.

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 25676-75-9, Name is 4-Bromo-1-methylimidazole, molecular formula is C4H5BrN2. In an article, author is Zhang, Kun-Peng,once mentioned of 25676-75-9, Application In Synthesis of 4-Bromo-1-methylimidazole.

Syntheses of Symmetric and Unsymmetric Bis-imidazole Derivatives Using Phase-Transfer Catalysis

A convenient method for the preparation of symmetric and unsymmetric bisimidazole derivatives was established. The symmetric bisimidazolylmethane derivatives 1a-9a was prepared with 2-substituted imidazole derivatives 1-9 as reaction materials. However, the symmetric and unsymmetric bisimidazolylmethane derivatives 10a-12a and 10b-12b was obtained, respectively. With 4-position with the azo-groups imidazole derivatives 10-12 were used as reaction materials. All these compounds have been structurally characterized by the NMR, ESI-MS, and EA. And 8a and 12a were also characterized by the X-ray single crystal diffusion.

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Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 25676-75-9, Name is 4-Bromo-1-methylimidazole. In a document, author is Tseng, Chih-Hua, introducing its new discovery. COA of Formula: C4H5BrN2.

Identification of furo[3 ‘,2 ‘:3,4]naphtho[1,2-d]imidazole derivatives as orally active and selective inhibitors of microsomal prostaglandin E-2 synthase-1 (mPGES-1)

This study describes the synthesis and anti-inflammatory effects of furo[3′, 2′:3,4]naphtho[1,2-d] imidazole derivatives. Among these furo[3′, 2′:3,4]naphtho[1,2-d]imidazole derivatives, 2-(4-methoxyphenyl)furo [3′, 2’:3,4]naphtho[1,2-d]imidazole (12) exhibited a strong inhibitory activity against LPS-induced PGE(2) production, with an IC50 value of 47 nM. Compound 12 is then further examined for its inhibitory effects in the protein expression of COX-2 and microsomal prostaglandin E-2 synthase-1 (mPGES-1) in Raw 264.7 cells. Our results indicate that compound 12 was capable against inhibiting LPS-induced mPGES-1 protein expression at a concentration of 1.0 mu M and no inhibitory effect in COX-2 expression. The sepsis-induced PGE(2) production in rat serum decreased similar to 250% by the pretreatment of 12 at 10 mg/kg. These results are especially important since compound 12 exhibited good oral bioavailability (72%) and was not cytotoxic at a concentration of 10.0 mu M. Therefore, compound 12 is a highly selective mPGES-1 inhibitor that can serve as a lead for the development of novel oral anti-inflammatory drug candidates.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 25676-75-9 help many people in the next few years. COA of Formula: C4H5BrN2.

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Formula: C4H5BrN2, 25676-75-9, Name is 4-Bromo-1-methylimidazole, SMILES is CN1C=NC(Br)=C1, in an article , author is Gupta, Sarita, once mentioned of 25676-75-9.

Synthesis and antimicrobial study of 2-amino-imidazole derivatives

A novel series of 2-amino-imidazole derivatives have been synthesized by conventional method from various di carbonyl compounds with substituted N-phenyl amides in presence of ammonium acetate and glacial acetic acid under reflux conditions with good yields. All the synthesized compounds have been characterized by IR, H-1 and C-13 NMR, mass and elemental analysis in full accordance with their depicted structures. The synthesized products have been screened for antimicrobial activity and the results reveal that introduction of amine at 2nd position of imidazole moiety enhances the antibacterial as well as antifungal activity.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 25676-75-9, you can contact me at any time and look forward to more communication. Formula: C4H5BrN2.

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 25676-75-9, Name is 4-Bromo-1-methylimidazole, formurla is C4H5BrN2. In a document, author is Nemati, Firouzeh, introducing its new discovery. Safety of 4-Bromo-1-methylimidazole.

Glycerol as a green solvent for efficient, one-pot and catalyst free synthesis of 2,4,5-triaryl and 1,2,4,5-tetraaryl imidazole derivatives

A simple, efficient and catalyst-free method has been developed for the synthesis of 2,4,5-triaryl and 1,2,4,5-tetraaryl imidazole derivatives in glycerol as green solvent at 90 degrees C. It is noteworthy that in this protocol the yields of products were comparable to or better than, those in conventional media. The use of green reaction media makes this methodology simple, safe and costeffective. (C) 2013 King Saud University. Production and hosting by Elsevier B.V.

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#REF!

Nontoxic corrosion inhibitors for copper in sulphuric acid

The aim of this paper is to study influence of the molecular structure on the inhibiting properties of organic compounds in corrosion processes in acid media. The inhibiting efficiency of nontoxic imidazole derivatives on copper corrosion in sulphuric acid is investigated. The investigation is performed using electrochemical methods of potentiodynamic polarization as well as gravimetric measurements. The results of the investigation show that the inhibiting properties of substituted imidazoles depend on molecular structure. The best protection (93%) is obtained by adding a phenyl ring to the imidazole structure. The values of standard free energies of adsorption, as calculated from the Freundlich isotherm, indicate that in the presence of sulphuric acid imidazole derivatives adsorb on copper by a physisorption-based mechanism.

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Adding a certain compound to certain chemical reactions, such as: 25676-75-9, name is 4-Bromo-1-methylimidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25676-75-9, Product Details of 25676-75-9

c) To a dry, N2 purged, 500 mL three neck flask equipped with a stir bar is added 200 mL of dry diethyl ether and 4-bromo-N-methylimidazole (50.0 g, 311 mmol). The flask is then cooled to -10 C. with an acetone/ice bath. A 2.0 M heptane/THF/ethylbenzene solution of lithium diisopropylamide (171 mL, 342 mmol) is then added via syringe while maintaining the reaction temperature at 0 C. or lower. After 1 hour, dimethylformamide (DMF) (36.1 mL, 466 mmol) is added dropwise over 5 minutes. The reaction mixture is allowed to stir for 45 minutes at or below 5 C. and then quenched with a saturated aqueous solution of citric acid. The resulting mixture is stirred vigorously until the two phases separate. The organic layer is recovered and washed (3*200 mL) with water. The solvent is removed in vacuo to give the desired product, 2-formyl-4-bromo-(1) N-methylimidazole, as a brown crystalline solid (yield: 55.7 g, 95 percent, 86 percent purity by GC). Additional purification may be achieved by elution through alumina using methylene chloride solvent.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-methylimidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Vosejpka, Paul C.; Boone, Harold W.; Frazier, Kevin A.; Iverson, Carl N.; US2009/69567; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25676-75-9, name is 4-Bromo-1-methylimidazole, A new synthetic method of this compound is introduced below., Safety of 4-Bromo-1-methylimidazole

To a solution of compound 121-4 (700 mg, 1.74 mmol, 1.0 eq), compound 121-4a (308 mg, 1.91 mmol, 1.1 eq), Cs2C03 (1.13 g, 3.48 mmol, 2.0 eq) in Dioxane (8 mL) and H20 (2 mL) was added Pd(PPh3)4 (101 mg, 87.0 umol, 0.05 eq) under N2. The reaction mixture was stirred at 90 C for 16 hours. The reaction mixture was concentrated under reduced pressure. The mixture was diluted with water (20 mL) and the resultant mixture was extracted with EA (50 mL * 3). The combined organic layers were dried over Na2SC>4, filtered and concentrated to dryness under reduced pressure. The residue was purified by preparative high performance liquid chromatography. The pure fractions were collected and the volatiles were removed under vacuum. The resulting mixture was lyophilized to dryness to remove the solvent residue completely. The title compound 121-5 (180 mg, 28% yield) was obtained. LCMS (ESI): RT = 0.592 min, mass calcd. for C18H20N4O2S 356.13, m/z found 356.9 [M+H]+, lH NMR (400MHz, CDCI3) delta 9.09 (s, 1H), 7.86 (d, J = 2.3 Hz, 1H), 7.49 (dd, J= 2.3, 8.8 Hz, 1H), 7.46 (s, 1H), 7.41 – 7.30 (m, 4H), 7.29 – 7.26 (m, 2H), 6.62 (d, J = 8.8 Hz, 1H), 4.53 (s, 2H), 4.21 (q, J= 5.4 Hz, 1H), 3.75 (s, 3H), 2.61 (d, J = 5.5 Hz, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; VIVACE THERAPEUTICS, INC.; KONRADI, Andrei W.; LIN, Tracy Tzu-Ling Tang; (294 pag.)WO2019/40380; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 25676-75-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25676-75-9 as follows.

Example 831 -Methylethyl [(2S,4/?)-1 -acetyl-2-methyl-6-(1 -methyl-1 H-imidazol-4-yl)-1 ,2,3,4- tetrahydro-4-quinolinyl]carbamate h drochlorideA mixture of 1 -methylethyl [(2S,4R)-1 -acetyl-2-methyl-6-(4,4,5,5-tetramethyl-1 ,3,2- dioxaborolan-2-yl)-1 ,2,3,4-tetrahydro-4-quinolinyl]carbamate (for a preparation, see Intermediate 52) (150 mg, 0.36 mmol), 4-bromo-1 -methylimidazole (0.43 mmol), tetrakis(triphenylphosphine)palladium(0) (42 mg, 10 mol%) and potassium carbonate (199 mg, 1 .44 mmol) in toluene (2 mL) and ethanol (2 mL) was refluxed for 16 h then cooled to room temperature and concentrated in vacuo. The residue was partitioned between AcOEt (10 mL) and water (10 mL) and the layers were separated. The organic phase was dried over MgS04 and concentrated in vacuo. Purification of the residue by flash chromatography on silica gel (gradient: 0 to 6% MeOH in DCM) gave a residue which was treated with 1 M HCI in Et20 (0.5 mL, slight excess). The solvent was evaporated and the residue triturated with Et20 to give 1 -methylethyl [(2S,4R)-1 -acetyl-2-methyl-6-(1 -methyl- 1 /-/-imidazol-4-yl)-1 ,2,3,4-tetrahydro-4-quinolinyl]carbamate hydrochloride (8 mg, 0.02 mmol, 5%) as a colourless solid. LCMS (method G): Retention time 0.56 min, [M+H]+ = 371.1

According to the analysis of related databases, 25676-75-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXOSMITHKLINE LLC; DEMONT, Emmanuel, Hubert; GARTON, Neil, Stuart; GOSMINI, Romain, Luc, Marie; HAYHOW, Thomas, George, Christopher; SEAL, Jonathan; WILSON, David, Matthew; WOODROW, Michael, David; WO2011/54841; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem