Category: 25676-75-9

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25676-75-9, name is 4-Bromo-1-methylimidazole, A new synthetic method of this compound is introduced below., Product Details of 25676-75-9

General procedure for preparation of Compound 10-6: A solution of Compound 10-3 (169 mg, 0.3 mmol) in a mixture of dioane (10 mL)-H20 (1 mL), was added Compound 10-5 (55.8 mg, 0.3 mmol), Cs2C03 (195 mg, 0.6 mmol) and Pd(dppf)Cl2 (22 mg, 0.03 mmol) and heated under irradiation of M W at 130C for 30 min under N2. Catalyst was filtered through diatomite and concentrated in vacuum to give the crude product (100 mg, yield 61.3%).

The synthetic route of 25676-75-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC; CHEN, Huifen; CRAWFORD, Terry; MAGNUSON, Steven, R.; NDUBAKU, Chudi; WANG, Lan; WO2013/113669; (2013); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25676-75-9 as follows. Computed Properties of C4H5BrN2

Step 2: preparation of benzyl 5-(1-methylimidazol-4-yl)isoindoline-2-carboxylate (compound 45b) To a solution of benzyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindoline-2-carboxylate (compound 45a, 76 mg, 0.20 mmol) in THF/H2O (4.5 mL, v/v = 8/1) was added 4-bromo-1-methyl-1H-imidazole (32 mg, 0.20 mmol), and K3PO4 (85 mg, 0.40 mmol). The solution was bubbled with N2 for 5 mins, then cataCXium A Pd G2 (134 mg, 0.20 mmol) was added. The mixture was heated at 75 C overnight, then cooled to rt and concentrated to give a crude product which was purified by column chromatography to give compound 45b (43 mg) as an oil. MS: calc’d 334 (MH+), measured 334 (MH+).

According to the analysis of related databases, 25676-75-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F. Hoffmann-La Roche AG; The designation of the inventor has not yet been filed; (99 pag.)EP3623369; (2020); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 25676-75-9, A common heterocyclic compound, 25676-75-9, name is 4-Bromo-1-methylimidazole, molecular formula is C4H5BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of (4-(aminomethyl)phenyl)boronic acid hydrochloride (0.85 g), 1,1′-bis(diphenylphosphino)ferrocene-palladium(II) dichloride dichloromethane complex (0.37 g), 4-bromo-1-methyl-1H-imidazole (0.80 g) and sodium carbonate (1.20 g) in DME (12 mL)-water (3 mL) was stirred under an argon atmosphere at 120C for 6 hr under microwave irradiation. To the reaction mixture was added 6N hydrochloric acid, and the mixture was washed with ethyl acetate. The aqueous layer was separated, neutralized with 8N aqueous sodium hydroxide solution, and concentrated under reduced pressure. The residue was washed with THF, and the obtained organic layer was concentrated. The residue was crudely purified by NH silica gel chromatography (hexane-ethyl acetate). The obtained crudely purified product was diluted with ethyl acetate, 4N hydrogen chloride ethyl acetate solution (1 mL) was added, and the resulting precipitate was collected by filtration, and dried to give the title compound (0.12 g). 1H NMR (300 MHz, DMSO-d6) delta 3.90 (3H, s), 4.05-4.10 (2H, m), 7.63 (2H, d, J = 8.3 Hz), 7.90 (2H, d, J = 8.3 Hz), 8.20 (1H, d, J = 1.1 Hz), 8.42 (3H, brs), 9.19 (1H, s), 1H not detected.

The synthetic route of 25676-75-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Takeda Pharmaceutical Company Limited; SUGIMOTO, Takahiro; NAKAMURA, Minoru; SAKAMOTO, Hiroki; SUZUKI, Shinkichi; YAMADA, Masami; KAMATA, Makoto; KOJIMA, Takuto; FUJIMORI, Ikuo; SHIMOKAWA, Kenichiro; EP2921480; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 25676-75-9, The chemical industry reduces the impact on the environment during synthesis 25676-75-9, name is 4-Bromo-1-methylimidazole, I believe this compound will play a more active role in future production and life.

Borylation: A flask is charged with Int 39 (458 mg, 1 mmol, 1 eq.), E^pim (381 mg, 1.5 mmol, 1.5 eq.), dioxane previously degassed with N2 (5 mL), potassium acetate (295 mg, 3 mmol, 3 eq.) and Pd(dppf)Cl2-DCM (82 mg, 0.10 mmol, 0.1 eq.). The mixture is stirred to 100 C overnight, concentrated in vacuo. The residue is diluted in DCM and water. The organic layer is separated and concentrated in vacuo, purified by flash chromatography on silica gel (eluting with DCM/MeOH 100/0 to 95/5) to afford the expected boronic ester and boronic acid mixture.LCMS: MW (calcd): 505.3; m/z MW (obsd): 506.3 (M+H).LCMS: MW (calcd): 423.1 ; m/z MW (obsd): 424.1 (M+H).; Suzuki coupling: To a stirred solution of boronic ester and boronic acid mixture (51 mg, 0.10 mmol, 1 eq.) and 4-bromo-l -methyl-imidazole (CAS 25676-75-9; 10 pL, 0.10 mmol, 1 eq.) in dioxane (2 mL) is added CS2CO3 (65 mg, 0.20 mmol, 2 eq.), Pd(PPh3)4 (12 mg, 0.01 mmol, 0.1 eq.) in water (0.5 mL). The mixture is heated to 90 C for 1 h then concentrated in vacuo. The residue is diluted in DCM and water. The organic layer is separated and concentrated in vacuo, purified by flash chromatography on Biotage SNAP KP-NH cartridge (eluting with DCM/MeOH 100/0 to 98/2) to afford the expected compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-methylimidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GALAPAGOS NV; ALVEY, Luke, Jonathan; ANNOOT, Denis, Maurice; BONNATERRE, Florence, Marie-Emilie; BUCHER, Denis; DUTHION, Beranger; JARY, Helene; PEIXOTO, Christophe; TEMAL-LAIB, Taoues; TIRERA, Amynata; (340 pag.)WO2019/105886; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 25676-75-9, The chemical industry reduces the impact on the environment during synthesis 25676-75-9, name is 4-Bromo-1-methylimidazole, I believe this compound will play a more active role in future production and life.

To a suspension of tert-butyl 4-({[2-amino-5-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)pyridin-3-yl]oxy}methyl)piperidine-1 -carboxylate (I-55) (1 1 .08 g, 27.2 mmol), 4-bromo-1 -methyl-1 H-imidazole (5.26 g, 32.7 mmol), Cs2C03 (2 N in H20, 27.2 mL, 54.5 mmol) in toluene (50 mL) and EtOH (150 mL) was added Pd(PPh3)4 (4.72 g, 4.08 mmol). The mixture was thoroughly degassed with N2 three times and the brown suspension was then stirred at 85 C for 16 hr under N2. LCMS showed the desired product by mass had formed. The reaction mixture was concentrated under vacuum to give a residue, which was diluted with CH2CI2 (300 mL), washed with water (50 mL), brine (30 mL), dried over Na2S04 and concentrated to give the crude product which was purified twice by silica gel chromatography (0 to 5% MeOH in CH2CI2 followed by CH2CI2/MeOH = 1 /0 to 20/1 ) to give tert-butyl 4-({[2-amino-5-(1 -methyl-1 H-imidazol-4-yl)pyridin-3-yl]oxy}methyl)piperidine-1 -carboxylate (~ 5.9 g as a brown solid. ~ 90% purity). This material was diluted with EtOAc / CH2CI2 (5:1 , 60 mL) and heated to 60 C until a clear solution was obtained. Cooling the solution to 25 C with concomitant reduction of the volume under reduced pressure (~10 mL) lead to the appearance of a precipitate. The suspension was filtered, the filter cake was washed with EtOAc/petroleum ether (1 :1 , 10 mL) and dried under vacuum to give tert-butyl 4-({[2-amino-5-(1 -methyl-1 H-imidazol-4-yl)pyridin-3-yl]oxy}methyl)piperidine-1 -carboxylate (1-106) (4.38 g, 42%) as a purple solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-methylimidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PFIZER INC.; JOHNSON, Ted William; RICHARDSON, Paul Francis; COLLINS, Michael Raymond; RICHTER, Daniel Tyler; BURKE, Benjamin Joseph; GAJIWALA, Ketan; NINKOVIC, Sacha; LINTON, Maria Angelica; LE, Phuong Thi Quy; HOFFMAN, Jacqui Elizabeth; (335 pag.)WO2016/97918; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 25676-75-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25676-75-9, name is 4-Bromo-1-methylimidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A deaerated mixture of 4-bromo-1-methyl-1H-imidazole (10) (0.800g, 5.00mmol), an arylboronic acid 7 (10.0mmol), CsF (2.28g, 15.0mmol), PdCl2(dppf) (0.183g, 0.25mmol), and BnEt3NCl (0.057g, 0.25mmol) in toluene (30mL) and water (30mL) was heated at reflux under argon for 48h. The mixture was then cooled to room temperature and partitioned between water and AcOEt, and the organic extract was dried and concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel to provide the desired product. This procedure was used to prepare compounds 9a and 9b, both in 95% yield.

The synthetic route of 4-Bromo-1-methylimidazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bellina, Fabio; Guazzelli, Nicola; Lessi, Marco; Manzini, Chiara; Tetrahedron; vol. 71; 15; (2015); p. 2298 – 2305;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

25676-75-9, name is 4-Bromo-1-methylimidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 25676-75-9

General procedure: A mixture of 4-methyl-3-(4-(pyridin-2-ylmethoxy)benzamido)phenyl boronic acid (50 mg, 0.14 mmol), Cs2CO3 (135 mg, 0.41 mmol), Pd(PPh3)4(23.93 mg, 0.02 mmol) and 4-bromo-1H-imidazole (26 mg, 0.18 mmol) was purged with nitrogen before adding degassed dioxane (690 muL) and water (230 muL) and heating in a microwave for 40 min at 150 C. After cooling, the aqueous layer was removed with a pipette, and the organic layer was diluted with DMSO (1 mL) and filtered through a 0.2 mum filter. The filtrate was concentrated to a volume of 1 mL and purified by Gilson HPLC (20-75% MeCN/10 mM NH4OAc in water). The fractions were concentrated and lyophilized to yield the product (19 mg, 0.049 mmol, 35%). 1H NMR (DMSO-d6) delta ppm 12.11 (s, 1H), 9.76 (s, 1H), 8.59 (d, 1H), 7.97 (d, 2H), 7.85 (td, 1H), 7.70 (s, 1H), 7.67 (s, 1H), 7.56 (m, 2H), 7.36 (dd, 1H), 7.21 (d, 1H), 7.15 (d, 2H), 5.27 (s, 2H), 2.18 (s, 3H). LCMS (M+H) = 385.

The synthetic route of 25676-75-9 has been constantly updated, and we look forward to future research findings.

In an article, author is Veeraragavan, Vijayakumar, once mentioned the application of 25676-75-9, Computed Properties of C4H5BrN2, Name is 4-Bromo-1-methylimidazole, molecular formula is C4H5BrN2, molecular weight is 161, MDL number is MFCD01320501, category is imidazoles-derivatives. Now introduce a scientific discovery about this category.

Molecular Docking Analysis of Imidazole Derivatives and Polybenzimidazole Analogs as Inhibitors of Superoxide Dismutase (SOD) and Xanthine Oxidase (XO)

The present study describes, molecular docking analysis of Imidazole derivatives and Polybenzimidazole (PBI) analogs as inhibitors of Superoxide dismutase (SOD) and Xanthine oxidase (XO). Twelve imidazole derivatives and twelve PBI analogs were evaluated on the docking behaviour of SOD and XO using PatchDock. Docking studies revealed that 1-Ethylimidazole and pyridine-PBI (1 Unit) showed the least atomic contact energy (-15.60 & -200.60 kcal/mol) with that of SOD. Similarly 1-Imidazole and pyridine-PBI (1 Unit) showed the least atomic contact energy (-68.01 & -80.88 kcal/mol) with that of XO. Hence, the results of this present study exhibited the potential of these Imidazole derivatives and Polybenzimidazole (PBI) analogs as SOD and XO inhibitory agents.

If you are interested in 25676-75-9, you can contact me at any time and look forward to more communication. Computed Properties of C4H5BrN2.

Application of 25676-75-9, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 25676-75-9, Name is 4-Bromo-1-methylimidazole, SMILES is CN1C=NC(Br)=C1, belongs to imidazoles-derivatives compound. In a article, author is Komori, K, introduce new discover of the category.

Toward selectivity control of a heme peptide electrode by modification with a phase-transition polymer

Reduction currents for H2O2 at a heme peptide (HP)-modified electrodes are suppressed by inhibitors, such as imidazole derivatives. Although this inhibition effect allows determinations of the total inhibition ability of imidazole derivatives, it has no selectivity. In this study the selectivity control of HP-modified electrodes for imidazole derivatives was performed utilizing the thermoresponsive phase transition of poly(N-isopropylacrylamide), which was chemically immobilized on HP-modified electrodes. The inhibition ratios for imidazole derivatives appeared to be small at temperatures below the lower critical solution temperature (LCST), and to be large above the LCST. This change was ascribed to a steric hindrance caused by a phase transition of the polymer. On the other hand, the inhibition ratio for histamine, which has a larger molecular size relative to imidazole, was not significantly changed by the phase transition. Thus, the selectivity of the HP-modified electrode was found to be controllable using an immobilized phase-transition polymer.

Application of 25676-75-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 25676-75-9 is helpful to your research.

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.25676-75-9, Name is 4-Bromo-1-methylimidazole, SMILES is CN1C=NC(Br)=C1, belongs to imidazoles-derivatives compound. In a document, author is Ravichandran, Revathy, introduce the new discover, SDS of cas: 25676-75-9.

MOLECULAR DOCKING STUDIES OF IMIDAZOLE DERIVATIVES AS NEW CLASS OF HIV-1 PROTEASE INHIBITOR

The human immunodeficiency virus (HIV) infects the immune system that leads to immune deficiency. Acquired immunodeficiency syndrome (AIDS) is defined as the most advanced stages of HIV infection. It is defined by the occurrence of any of more than 20 opportunistic infections or HIV-related cancers. According WHO and UNAIDS estimation, 36.7 million people were living with HIV globally by the end of 2015. 2.1 million People became newly infected, and 1.1 million died of HIV-related causes at the same year. HIV-1 protease plays a vital role in the maturation of virus in order to produce the infectious viral particles. In this study, molecular docking was performed on various imidazole derivatives by Autodock 4.2 into active sites of HIV-1 protease (PDB ID: 4RVI).

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 25676-75-9 is helpful to your research. SDS of cas: 25676-75-9.