Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 256519-11-6, name is 2-Chloro-7-fluoro-1H-benzo[d]imidazole, A new synthetic method of this compound is introduced below., Formula: C7H4ClFN2
A mixture of 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5- (piperidin-3-yl)benzofuran-3-carboxamide (80 mg, 0.174 mmol), 2-chloro-4-fluoro-1H-benzo[d]imidazole (47.5 mg, 0.279 mmol) and triethylamine (90 mg, 0.696 mmol) in DMF (1 ml)was heated to 170C for 40 mm. The reaction mixture was cooled to RT and partitioned between EtOAc and water. The organic layer was dried in Na2SO4 and concentrated under vacuum. Then the reaction mixture separated by SFC on a ChiralPark AD, 3×25 cm, 40% MeOH(0.1%NH3.H20)/C02 to afford Example 55 (Enantiomer 1, peak 1 on SFC, HPLC_RT=3.91mm) as white solid 5 mg (10%) (LC-MS (ES, mlz) C30H29F2N5045: 593; Found: 594 [M+H]b) and Example 56 (Enantiomer 2, peak 2 on SFC, HPLC_RT=6.34 mm) as white solid 5 mg (10%) (LCMS (ES, mlz) C30H29F2N504S: 593; Found: 594 [M+Hf).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MERCK SHARP & DOHME CORP.; HE, Shuwen; LAI, Zhong; DAI, Xing; XIAO, Dong; LONDON, Clare; ZORN, Nicolas; NARGUND, Ravi; PALANI, Anandan; MCCOMAS, Casey C.; LI, Peng; PENG, Xuanjia; SOLL, Richard; WO2014/205592; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem