Category: 256518-97-5

Application of 256518-97-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 256518-97-5 as follows.

Step 5: Under nitrogen protection, 2-chloro-6-iodo-1H-benzimidazole (2.34 g, 8.4 mmol) was added to the reaction vessel.Isopropyl boric acid (0.81 g, 9.2 mmol), tetrakistriphenylphosphine palladium (0.05 g, 0.04 mmol),Potassium carbonate (1.74 g, 12.6 mmol), toluene 60 mL, ethanol 20 mL, and distilled water 20 mL were stirred at 120 C for 3 h.After the end of the reaction, the reaction was quenched with distilled water, extracted with ethyl acetate and dried over MgSO 4The solvent was evaporated under reduced pressure, and then purified by silica gel column chromatography to afford compound 35-5 (1.26 g, 77%).

According to the analysis of related databases, 256518-97-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Changchun Hai Purunsi Technology Co., Ltd.; Dong Xiuqin; Cai Hui; (23 pag.)CN109305943; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 256518-97-5, name is 2-Chloro-5-iodo-1H-benzo[d]imidazole, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 256518-97-5

2-Chloro-6-iodo-1H-benzimidazole (2.34 g, 8.4 mmol) was added to the reaction vessel under nitrogen atmosphere.Isopropyl boric acid (0.81 g, 9.2 mmol),Tetrakistriphenylphosphine palladium (0.09g, 0.08mmol),Potassium carbonate (3.48g, 25.2mmol),Toluene 60mL, ethanol 20mL and distilled water 20mL,Stir at 120 C for 3 h.After the end of the reaction, the reaction was quenched with distilled water, extracted with ethyl acetate, and the organic layer was dried over MgSO 4After purification by silica gel column chromatography, Intermediate 21-3 (1.23 g, 75%) was obtained

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 256518-97-5.

Reference:
Patent; Changchun Hai Purunsi Technology Co., Ltd.; Dong Xiuqin; Cai Hui; (20 pag.)CN108727274; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

These common heterocyclic compound, 256518-97-5, name is 2-Chloro-5-iodo-1H-benzo[d]imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-Chloro-5-iodo-1H-benzo[d]imidazole

2-Chloro-6-iodo-1H-benzimidazole (2.34 g, 8.4 mmol), isopropylboronic acid (0.81 g, 9.2 mmol), tetrakistriphenylphosphine palladium (0.09 g, 0.08 mmol) were added to the reaction vessel. Potassium carbonate (3.48g,25.2 mmol), 60 mL of toluene, 20 mL of ethanol and 20 mL of distilled water were stirred at 120 C for 3 h. After the completion of the reaction, the reaction was quenched with distilled water, ethyl acetate was evaporated, and the organic layer was dried (MgSO4).(1.18g, 72%).

The synthetic route of 2-Chloro-5-iodo-1H-benzo[d]imidazole has been constantly updated, and we look forward to future research findings.