Category: 255064-08-5

Related Products of 255064-08-5,Some common heterocyclic compound, 255064-08-5, name is 6-Bromo-1H-benzo[d]imidazole-4-carboxylic acid, molecular formula is C8H5BrN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To 4-carboxy-6-bromobenzimidazole (3.49 g, 14.5 mmol), 3-aminomethyl-4,6-dimethylpyridin-2-one (3.32 g, 21.75 mmol,), EDCI (4.18g, 21.75mmol) and HOBT (2.94g, 21.75mmol) DMSO (15ml) N-methylmorpholine (5.87 g, 58 mmol) was quickly added to the solution. The solid slowly dissolved and allowed to react overnight at room temperature. The reaction solution was poured into ice water, stirred, allowed to stand, solid filtered, washed with water and dried to give a solid.

The synthetic route of 255064-08-5 has been constantly updated, and we look forward to future research findings.

Reference of 255064-08-5, These common heterocyclic compound, 255064-08-5, name is 6-Bromo-1H-benzo[d]imidazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 6-bromo-1H-benzo[d]imidazole-4-carboxylic acid(200 mg,0.84mmol) in THF(5 mL) and MeOH(1 mL) at 0 C was added trimethylsilyldiazomethane inEt20(2.0 M,0.63 mL,1.3 mmol). The reaction was stirred for 1 hat 0 C then warmed toRT.The reaction was quenched by addition of AcOH dropwise and concentrated in vacuo. Thecrude residue was diluted with DCM(20 mL) and washed with brine(10 mL). The organiclayer was dried over MgS04,filtered,and concentrated in vacuo. To a solution of the cruderesidue in DMF(2 mL) was added NaH(30 mg,1.25 mmol) at RT and stirred for 30 min.methyl iodide(120 mg,0.84 mmol) was added,and the reaction was stirred for 4 h at RT.The reaction mixture was cooled to-78 C and quenched with MeOH. The mixture wasdiluted into DCM/H20(20 mL,1:1),the organic layer separated and the aqueous layer wasextracted with DCM(2 x 5 mL). The combined organic extracts were dried over MgS04,filtered,and concentrated in vacuo. The crude residue was purified by reverse phasepreparative HPLC(Phenomenex Gemini C 18,H20/CH3CN gradient to 20-80 % MeCN 0.1%TFA) to aHord the title compound(83 mg,37%).

Statistics shows that 6-Bromo-1H-benzo[d]imidazole-4-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 255064-08-5.