Reference of 25372-03-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25372-03-6 as follows.
56 g (0.33 mol) of 1-(4-cyanophenyl)imidazole are dissolved in 560 ml water-free tetrahydrofuran in a 2000 ml one-necked flask with condenser, admixed with 234.2 g (1.65 mol) of methyl iodide, stirred briefly and allowed to stand for 48 hours without further stirring. The solid contents of the flask are subsequently slurried with ethanol, filtered off with suction and washed with ethanol until the washings are virtually colorless. The residue is dried at 70° C. under reduced pressure. The yield is 81.54 g (80percent of theory).1H-NMR (400 MHz, DMSO): delta=3.97 (s, 3H); 8.00-8.04 (m, 3H); 8.22 (d, J=9.0 Hz, 2H); 8.40 (dd, J=1.8, 1.8 Hz, 1H); 9.91 (s, 1H). Elemental analysis: calculated for C11H10IN3: C, 42.4; H, 3.3; N, 13.5; I 40.0, found: C, 42.6; H, 2.9; N, 13.6; I 40.9.
According to the analysis of related databases, 25372-03-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BASF SE; US2009/18330; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem