250285-32-6 Archives - Page 8 of 11 - Imidazoles-derivatives

Jiang, Binyang team published research on Chinese Journal of Chemistry in 2022 | 250285-32-6

Computed Properties of 250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., 250285-32-6.

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Computed Properties of 250285-32-6.

Jiang, Binyang;Shi, Shi-Liang research published 《 Pd-Catalyzed Cross-Coupling of Alkylzirconocenes and Aryl Chlorides》, the research content is summarized as follows. The first Pd-catalyzed aryl-alkyl cross-coupling of alkylzirconocenes and aryl halides was reported. A com. available N-heterocyclic carbene (IPr) as the ligand for palladium catalyst was critical to enable the challenging process. This mild protocol does not require base additives and tolerated a broad scope of both coupling partners bearing various functional groups and heterocycles. Moreover, both terminal and internal alkenes were applicable, and the latter underwent “chain walking”, giving the terminal coupling product exclusively. Preliminary mechanistic studies revealed a precatalyst activation pathway and inhibited β-H elimination due to steric bulk of NHC ligand.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Jiang, Kunming team published research on Journal of the American Chemical Society in 2020 | 250285-32-6

Related Products of 250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Related Products of 250285-32-6.

Jiang, Kunming;Han, Shantao;Ma, Mingyu;Zhang, Lu;Zhao, Yucheng;Chen, Mao research published 《 Photoorganocatalyzed Reversible-Deactivation Alternating Copolymerization of Chlorotrifluoroethylene and Vinyl Ethers under Ambient Conditions: Facile Access to Main-Chain Fluorinated Copolymers》, the research content is summarized as follows. Fluoropolymers have found broad applications for many decades. Considerable efforts have focused on expanding ac-cesses toward main-chain fluorinated polymers. In contrast to previous polymerizations of gaseous fluoroethylenes con-ducted at elevated temperatures and with high-pressure metallic vessels, we here report the development of a photoor-ganocatalyzed reversible-deactivation radical alternating copolymerization of chlorotrifluoroethylene (CTFE) and vinyl ethers (VEs) at room temperature and ambient pressure by exposing to LED light irradiation This method enables the synthesis of various fluorinated alternating copolymers with low ETH and high chain-end fidelity, allowing iterative switch of the copolymerization between “ON” and “OFF” states, the preparation of fluorinated block alternating copolymers, as well as post-synthetic modifications.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Jiang, Nan team published research on ChemCatChem in 2021 | 250285-32-6

Name: 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Jiang, Nan;Mei, Yuling;Yang, Yu;Dong, Youxian;Ding, Zekun;Zhang, Jianbo research published 《 A General Strategy for the Stereoselective Synthesis of Pyrrole-Fused Chiral Skeletons: [3+2] Cycloaddition with 2-Nitro-2,3-Unsaturated Glycosides》, the research content is summarized as follows. In this study, a two-step methodol. was developed for the synthesis of chiral pyrroles from 2-nitroglycals via Ferrier rearrangement and Barton-Zard reaction under mild conditions without transition metal catalysts. The Ferrier rearrangement reaction of 2-nitro-glycals and a series of O-nucleophiles proceeded smoothly in the presence of N-heterocyclic carbene (NHC) catalyst and K₂CO₃ which allowed the highly stereoselective synthesis of the diverse 2-nitro-2,3-unsaturated glycosides in excellent yields. Subsequently, the rearrangement products were conveniently transformed into the desired chiral pyrroles by [3+2] cycloaddition (Barton-Zard reaction) with isocyanoacetate in the presence of Cs₂CO₃. One-pot strategy was also successfully demonstrated for the gram-scale synthesis of one chiral pyrrole. This is the first report of stereoselective conversion from 2-nitroglycals to chiral pyrrole.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Jo, Minyoung team published research on Dalton Transactions in 2020 | 250285-32-6

250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. Category: imidazoles-derivatives.

Jo, Minyoung;Li, Jingbai;Dragulescu-Andrasi, Alina;Rogachev, Andrey Yu.;Shatruk, Michael research published 《 Incorporation of coinage metal-NHC complexes into heptaphosphide clusters》, the research content is summarized as follows. Cu(I) and Au(I) ions, capped with an N-heterocyclic carbene (NHC), react with (TMS)₃P₇ (TMS = trimethylsilyl) to afford an η⁴-coordinated anion [NHC^DippCu-P₇(TMS)]^– and a neutral trinuclear complex (NHC^DippAu)₃P₇. Protecting the P₇ cage with the TMS groups is instrumental in controlling these reactions.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Johnson, Chloe team published research on ChemCatChem in 2021 | 250285-32-6

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Johnson, Chloe;Dabral, Saumya;Rudolf, Peter;Licht, Ulrike;Hashmi, A. Stephen K.;Schaub, Thomas research published 《 Liquid-liquid-phase Synthesis of exo-Vinylene Carbonates from Primary Propargylic Alcohols: Catalyst Design and Recycling》, the research content is summarized as follows. A straight-forward approach to sep. catalyst from the exo-vinylene carbonate (EVC) products of the carboxylative cyclisation of primary propargylic alcs. has been developed. The liquid-liquid phase synthesis utilizes lipophilic silver(I) carboxylate salts and N,N-dioctyl modified phosphine (FatPhos) ligands to enhance catalyst solubility in non-polar solvents. Following simple liquid-liquid phase separation, EVCs relevant as monomers for poly(urethane) and poly(carbonate) synthesis were isolated in the non-miscible polar phase in good yields. In situ reaction monitoring by ReactIR gave insights into the reaction kinetics and informed the conditions used to afford good EVC selectivity. Under optimized conditions, silver leaching into the product phase was very minor as confirmed by ICP-MS. Furthermore, a protocol for catalyst recycling by liquid-liquid separation was demonstrated, with modest loss of catalytic activity over 3 runs.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Jonsson, Helgi Freyr team published research on Dalton Transactions in 2021 | 250285-32-6

Application In Synthesis of 250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Jonsson, Helgi Freyr;Fiksdahl, Anne;Harvie, Andrew J. research published 《 Rapid and mild synthesis of Au-NHC complexes in a simple two-phase flow reactor》, the research content is summarized as follows. We describe a simple two-phase flow reactor which allows for the rapid synthesis of several Au(I)-NHC complexes in high yields (>88%), under mild conditions, and with minimal workup. Translation of the standard weak base method to a two-phase flow reaction prevents the common problem of decomposition to Au(0). The reaction can be scaled up more than ten-fold without loss in conversion efficiency. An optional second stage allows for direct synthesis of Au(III)-NHC complexes, without isolation of the Au(I)-NHC intermediate, with a two-step isolated yield of 82%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Jenkins, Aireal D. team published research on Journal of Organic Chemistry in 2020 | 250285-32-6

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Computed Properties of 250285-32-6.

Jenkins, Aireal D.;Robo, Michael T.;Zimmerman, Paul M.;Montgomery, John research published 《 Nickel-Catalyzed Three-Component Cycloadditions of Enoates, Alkynes, and Aldehydes》, the research content is summarized as follows. A method for the three-component cycloaddition of aldehydes R¹CHO (R¹ = Ph, i-Pr), enoates PhOC(O)C(R²)=CHR³ (R² = H, Me; R³ = H, Me, Ph), and alkynes R⁴CCR⁵ (R⁴ = Me, n-Pr, (CH₂)₃OTBS, (CH₂)₂C(O)₂Me; R⁵ = Ph, n-Pr) has been developed. Building upon previous work by this group in which stoichiometrically generated metallacycles undergo alkylation, a catalytic, alkylative [3+2] cycloaddn was reported. From simple starting materials, structurally complex cyclopentenones I may be rapidly assembled. Computational investigation of the mechanism (ωB97X-D3/cc-pVTZ // ωB97X/6-31G(d)) identified three energetically feasible pathways. Based on the relative rates of ketene formation compared to isomerization to a 7-membered metallacycle, the most likely mechanism has been determined to occur “ketene-first”, with carbocyclization prior to aldol addition Deuterium labeling studies suggest that formation of the 7-membered metallacycle becomes possible when an α-substituted enoate is used. This observed change in selectivity is due to the increased difficulty of phenoxide elimination with the inclusion of addnl. steric bulk of the α-substituent. The net transformation results in a [3+2] cycloaddition accompanied by an alkylation of the enoate substituent.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Jia, Jie team published research on Organic Letters in 2022 | 250285-32-6

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Jia, Jie;Yuan, Fushan;Zhang, Zihao;Song, Xuejiao;Hu, Fangdong;Xia, Ying research published 《 Copper-Catalyzed Ring-Opening Defluoroborylation of gem-Difluorinated Cyclobutenes: A General Route to Bifunctional 1,3-Dienes and Their Applications》, the research content is summarized as follows. The exploration of the reactivity of gem-difluorinated small-size rings has continuously drawn attention in recent years but is limited to three-membered carbocycles. Herein, the authors report a Cu-catalyzed reaction of gem-fluorinated cyclobutenes with bis(pinacolato)diboron (B₂pin₂). A sequence of defluoroborylation and ring opening process produces B,F-bifunctional 1,3-dienes in a stereoselective manner. The transformation together with the efficient downstream coupling of the boronate and the fluoride moiety collectively constitutes a modular route to highly functionalized and stereocontrolled 1,3-dienes.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Guillet, Sebastien G. team published research on Chemical Communications (Cambridge, United Kingdom) in 2020 | 250285-32-6

SDS of cas: 250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Guillet, Sebastien G.;Voloshkin, Vladislav A.;Saab, Marina;Belis, Marek;Van Hecke, Kristof;Nahra, Fady;Nolan, Steven P. research published 《 Understanding existing and designing novel synthetic routes to Pd-PEPPSI-NHC and Pd-PEPPSI-PR₃ pre-catalysts》, the research content is summarized as follows. The reaction mechanism giving cross-coupling Pd pre-catalysts of the PEPPSI family was studied. Two intermediates were isolated and are both suitable synthons to the pre-catalysts, with one permitting the design of a novel and greener user-friendly synthetic route. In light of this mechanistic understanding, the traditional 1-pot method is possible using stoichiometric amounts of throw-away ligand, which represents a considerable synthetic improvement over the wasteful in pyridine approach.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hao, Guiyun team published research on Bioorganic & Medicinal Chemistry in 2021 | 250285-32-6

Formula: C27H37ClN2, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Imidazole based anticancer drug find applications in cancer chemotherapy. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Formula: C27H37ClN2.

Hao, Guiyun;Li, Hao;Yang, Fei;Dong, Duoling;Li, Zezhong;Ding, Yingying;Pan, Wei;Wang, Enduo;Liu, Rujuan;Zhou, Huchen research published 《 Discovery of benzhydrol-oxaborole derivatives as Streptococcus pneumoniae leucyl-tRNA synthetase inhibitors》, the research content is summarized as follows. 1-Hydroxy-2,1-benzoxaboroles I were prepared and examined for inhibitory activity against leucyl-tRNA synthetase (LeuRS) and antibacterial activity against multidrug-resistant S. pneumoniae pathogen. Pneumonia caused by bacterium S. pneumoniae is a severe acute respiratory infectious disease with high morbidity and mortality, especially for children and immunity-compromised patients. The emergence of multidrug-resistant S. pneumoniae also presents a challenge to human health. Leucyl-tRNA synthetase (LeuRS) catalyzes the attachment of L-leucine to tRNA^Leu, which plays an essential role in protein translation and is considered an attractive antimicrobial drug target. In the present work, benzhydrol-oxaborole hybrid compounds were designed and synthesized as inhibitors of S. pneumoniae LeuRS. Exploration of the Ph ring near Lysine 389 eventually yielded compounds 46 and 54 with submicromolar inhibitory potency. The co-crystal of compound 54 in the editing domain pocket of SpLeuRS was obtained and confirmed the formation of an addnl. hydrogen bond between the carbonyl of 54 and Lysine 389. It also showed anti-pneumococcal activity in vitro. The structure-activity relationship was discussed. This work will provide an essential foundation for the further development of anti-pneumococcal agents by targeting LeuRS.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem