Category: 2466-76-4

These common heterocyclic compound, 2466-76-4, name is 1-(1H-Imidazol-1-yl)ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2466-76-4

Nucleoside/nucleotide (2; 100 mM) and N-acetyl imidazole (1a;10 equiv) were dissolved in water (pH 8; adjusted with 4 MNaOH). The solution was incubated at r.t. for 4 h, and NMR spectra were periodically acquired. The product was purified byreverse-phase (C18) flash coumn chromatography (eluted at pH4 with 100 mM NH4HCO2/MeCN = 98:2 to 80:20). The fractions containing 5 were lyophilised to yield a white powder.Selected Data: 2?,3?-Di-O-acetyl-beta-cytidine-5?-phosphate (5a)Starting from 1a (160 mg, 0.50 mmol), 5a (172 mg, 85percent) wasobtained as a white powder. 1H NMR (600 MHz, D2O): delta = 8.08[d, J = 7.9 Hz, 1 H, H-(C6)], 6.22 [d, J = 7.9 Hz, 1 H, H-(C5)], 6.11[d, J = 5.1 Hz, 1 H, H-(C1?)], 5.41 [dd, J = 5.4, 5.1 Hz, 1 H, H-(C2?)],5.38 [dd, J = 5.4, 4.4 Hz, 1 H, H-(C3?)], 4.48 [ddd, J = 4.9, 4.4, 2.4Hz, 1 H, H-(C4?)], 4.13 [ABXY, J = 11.9, 4.4, 2.4 Hz, 1 H, H-(C5?)],4.02 [ABXY, J = 11.9, 4.9, 2.4 Hz, 1 H, H-(C5??)], 2.09 [s, 3 H, Ac-(C3?)], 2.05 [s, 3 H, Ac-(C2?)]. 13C NMR (151 MHz, D2O): delta = 173.4(3?-OAc), 173.1 (2?-OAc), 160.7 (C4), 150.1 (C2), 144.3 (C6), 96.5(C5), 88.2 (C1?), 82.5 (d, C4?), 74.5 (C2?), 71.5 (C3?), 64.4 (d, C5?),20.6 (3?-OAc), 20.5 (2?-OAc). 31P NMR (162 MHz, D2O, 1H-decoupled):delta = 0.30. IR (neat): 1746, 1660, 1489, 1462, 1429, 1375,1075 cm?1. ESI-HRMS: m/z [M + H+] calcd for C13H19N3O10P:408.0803; found: 408.0810.

The synthetic route of 1-(1H-Imidazol-1-yl)ethanone has been constantly updated, and we look forward to future research findings.

Related Products of 2466-76-4, These common heterocyclic compound, 2466-76-4, name is 1-(1H-Imidazol-1-yl)ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

rac-3-acetyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester (Starting Product for Example 19) A solution of 4-oxo-piperidine-1-carboxylic acid tert-butyl ester (2.5 mmol) in absolute THF (1 ml) was added at -78° C. to a freshly prepared solution of LDA (2.76 mmol) in absolute THF (2 ml) and was stirred at this temperature for 2 h. Then acetylimidazole (2.76 mmol) dissolved in THF (1.5 ml) was added dropwise and the reaction mixture was stirred overnight, with warming to room temperature. The addition of saturated ammonium chloride solution was followed by extraction three times with ether, the combined organic phases were washed with water and saturated sodium chloride solution, dried over sodium sulphate and the solvent was removed in a vacuum. After column chromatography purification on silica gel with hexane/EtOAc 5:1 the product is obtained as a yellow oil. tR 2.09; MS (neg. Ion.) m/z 240.41 [M-H]-. (J. Med. Chem. 1989, 32(2), 351-357).

The synthetic route of 2466-76-4 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 2466-76-4, The chemical industry reduces the impact on the environment during synthesis 2466-76-4, name is 1-(1H-Imidazol-1-yl)ethanone, I believe this compound will play a more active role in future production and life.

Triethylamine (217 mg, 2.15 mmol), followed by 1-acetylimidazole (95 mg, 0.86 mmol), was added to a solution of the product from step 2 (200 mg, 0.43 mmol) in methylene chloride (5 mL). The reaction mixture was stirred at room temperature for 16 h. The solvent was removed under reduced pressure. The residue was dissolved in methanol (6 mL) and water (3 mL) and treated with potassium carbonate (300 mg, 2.17 mmol). The reaction mixture was stirred at room temperature for 2 h. The solvent was removed under reduced pressure. The residue was acidified with 1 N hydrochloric acid and extracted with ethyl acetate. The combined extracts were washed with saturated sodium chloride, and dried (sodium sulfate), filtered, and concentrated under reduced pressure. Purification by flash column chromatography (silica gel, 0-5percent methanol/methylene chloride provided the desired product (85 mg, 49percent) as a white foam. ESI MS m/z 407 [C2, H24F2N204 + H] + ; HPLC (Phenomenex Luna C18 (2) Column, 150 x 4.6 mm, 5R ; A: 0.05percent TFA in 95: 5 H20/CH3CN ; B: 0.05percent TFA in 5: 95 H20/CH3CN ; Gradient: 30-100percent B over 15 min; flow 1.0 mUmin ; Detection: 254 nm) 98.0percent (AUC), tR = 7.01 min. Anal. Calc’d for C21H24F2N2O4No.O. 25 H20 : C, 61.38 ; H, 6.01 ; N, 6.82 ; found: C, 61.60 ; H, 5.68 ; N, 6.59.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(1H-Imidazol-1-yl)ethanone, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ELAN PHARMACEUTICALS, INC.; WO2005/87714; (2005); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 2466-76-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2466-76-4 name is 1-(1H-Imidazol-1-yl)ethanone, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a solution of N -acetylimidazole 7a (1 mmol) and a suitable Baylis-Hillman acetate 1 (1 mmol) in DMF (1 mL), K2CO3 (1 mmol) was added and the resulting mixture was stirred at room temperature until complete consumption of N -acetylimidazole 7a. The reaction mixture was then diluted with water (20 mL) and extracted with ethyl acetate (3×20 mL). The combined organic layers were washed with brine and dried over anhydrous Na2SO4 . After removal of the solvent under reduced pressure, the residue was puried by flash chromatography over silica gel with EtOAc and hexane (1:1).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(1H-Imidazol-1-yl)ethanone, and friends who are interested can also refer to it.

Reference:
Article; Koeseceli Oezenc, Ay?en; Celik, Ilhami; Koekten, ?ule; Turkish Journal of Chemistry; vol. 41; 3; (2017); p. 323 – 334;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 2466-76-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2466-76-4 name is 1-(1H-Imidazol-1-yl)ethanone, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Nucleoside/nucleotide (2; 100 mM) and N-acetyl imidazole (1a;10 equiv) were dissolved in water (pH 8; adjusted with 4 MNaOH). The solution was incubated at r.t. for 4 h, and NMR spectra were periodically acquired. The product was purified byreverse-phase (C18) flash coumn chromatography (eluted at pH4 with 100 mM NH4HCO2/MeCN = 98:2 to 80:20). The fractions containing 5 were lyophilised to yield a white powder.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(1H-Imidazol-1-yl)ethanone, and friends who are interested can also refer to it.

Reference:
Article; Fernandez-Garcia, Christian; Powner, Matthew W.; Synlett; vol. 28; 1; (2017); p. 78 – 83;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 2466-76-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2466-76-4 name is 1-(1H-Imidazol-1-yl)ethanone, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The amine precursor 16 (100,7 mg, 0.240 mmol, 1 eq.) was dissolved in 1 ml of DMF, acetylimidazole (31.7 mg, 0.288 mmol, 1.2 eq) and DIPEA (0.090 ml, 0.48 mmol, 2 eq.) wereadded to the solution. After stirring the mixture for 48h at room temperature, the solvent was evaporated under reduced pressure to give the corresponding crude, which was purified by HPLC using a gradient of 5percent to 95percent v/v acetonitrile in 0.1percent aqueous solution of formic acid to yield the titled compound. Yield: 91 mg, 0.187 mmol (78percent). 1H NMR (400 MHz, CDCI3) 9.25 (1H, 5), 8.70 (1H, 5), 7.97 (1H, t, J=6.5 Hz), 7.15 (1H, d, J=7.5 Hz), 6.83-6.80 (2H, m),6.72 (1H, d, J=8.8 Hz), 4.92-4.88 (1H, m), 4.57 (1H, 5), 4.52-4.42 (2H, m), 4.26-4.14 (2H, m), 3.59 (1H, dd, J=2.9, 11.1 Hz), 2.53-2.45 (4H, m), 2.24-2.17 (1H, m), 1.85 (3H, 5), 0.83 (9H, 5); 13C NMR (101 MHz, ODd3) O 171.8, 171.2, 155.9, 150.7, 148.1, 132.8, 131.7, 131.0, 124.2, 120.6, 117.1, 70.3, 58.1, 57.7, 57.1, 39.8, 35.5, 34.8, 26.3, 22.6, 16.0. HRMS (ESI) m/z: [M+H] calculated for: C24H32N405S: 488.21; observed: 484.3.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(1H-Imidazol-1-yl)ethanone, and friends who are interested can also refer to it.

Reference:
Patent; UNIVERSITY OF DUNDEE; CIULLI, Alessio; MANIACI, Chiara; HUGHES, Scott J.; TESTA, Andrea; (111 pag.)WO2018/189554; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

2466-76-4, name is 1-(1H-Imidazol-1-yl)ethanone, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 2466-76-4

[00123] Methyl 2-(2-bromophenyl)-3-oxobutanoate: A round bottom flask was charged with a magnetic stir bar and methyl 2- (2-bromophenyl) acetate (25 g, 109 mmol) and THF (50 mL). This solution was cooled to -78 ¡ãC before drop wise addition of a 1M solution of LiHMDS in THF (218 ml, 218 mmol). The reaction was stirred for 30 min at -78 ¡ãC before addition of l-(lH-imidazol-l-yl)ethanone (14.42 g, 131 mmol) as a solution in a mixture of THF:DMF (112 mL THF, 24 mL DMF). The solution was stirred for 1 h before quenching with sat’d aqueous NH4C1 (-250 mL) and diluting with EtOAc. The layers were separated and the aqueous phase was extracted with additional EtOAc (~2 x 250 mL). The combined organic extract was washed with brine, dried over Na2S04, filtered, and concentrated in vacuo. The crude residue was purified via silica gel chromatography using an eluent of ethyl acetate/hexanes (10: 1) to afford methyl 2-(2-bromophenyl)-3-oxobutanoate (32.5 g, 102 mmol, 93 percent ield).

The synthetic route of 2466-76-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; AUDIA, James, Edmund; DAKIN, Les, A.; DUPLESSIS, Martin; GEHLING, Victor, S.; HARMANGE, Jean-Christophe; NASVESCHUK, Christopher, G.; VASWANI, Rishi, G.; WO2015/23915; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 2466-76-4, name is 1-(1H-Imidazol-1-yl)ethanone, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2466-76-4, HPLC of Formula: C5H6N2O

General procedure: Nucleoside/nucleotide (2; 100 mM) and N-acetyl imidazole (1a;10 equiv) were dissolved in water (pH 8; adjusted with 4 MNaOH). The solution was incubated at r.t. for 4 h, and NMR spectra were periodically acquired. The product was purified byreverse-phase (C18) flash coumn chromatography (eluted at pH4 with 100 mM NH4HCO2/MeCN = 98:2 to 80:20). The fractions containing 5 were lyophilised to yield a white powder.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(1H-Imidazol-1-yl)ethanone, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Fernandez-Garcia, Christian; Powner, Matthew W.; Synlett; vol. 28; 1; (2017); p. 78 – 83;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2466-76-4 as follows. name: 1-(1H-Imidazol-1-yl)ethanone

General procedure: To a solution of N -acetylimidazole 7a (1 mmol) and a suitable Baylis-Hillman acetate 1 (1 mmol) in DMF (1 mL), K2CO3 (1 mmol) was added and the resulting mixture was stirred at room temperature until complete consumption of N -acetylimidazole 7a. The reaction mixture was then diluted with water (20 mL) and extracted with ethyl acetate (3×20 mL). The combined organic layers were washed with brine and dried over anhydrous Na2SO4 . After removal of the solvent under reduced pressure, the residue was puried by flash chromatography over silica gel with EtOAc and hexane (1:1).

According to the analysis of related databases, 2466-76-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Koeseceli Oezenc, Ay?en; Celik, Ilhami; Koekten, ?ule; Turkish Journal of Chemistry; vol. 41; 3; (2017); p. 323 – 334;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 2466-76-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2466-76-4, name is 1-(1H-Imidazol-1-yl)ethanone belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Step 3; Preparation of N-I (lS, 2R)-l- (3, 5-difluorobenzyl) -2- hydroxy-3- [ (6-iodo-3, 4-dihydro-2H-chromen-4- yl) amino] propyl} acetamide; Tert-butyl (1S, 2R)-1- (3, 5-difluorobenzyl)-2-hydroxy-3- [ (6-iodo- 3,4-dihydro-2H-chromen-4-yl) amino] propylcarbamate (3.0 g, 5.2 mmol) was dissolved in 30 mL of 25percent TFA/CH2Cl2 and stirred at room temperature for 30 min. The mixture was diluted with CH2Cl2 50 mL and washed with NaHC03 (2 x 30 mL). The organic layer was washed with brine (1 x 50 mL) and dried over Na2SO4. The solvent was removed in vacuo and the resulting residue dissolved in 52 mL of CH2Cl2. The mixture was chilled to 0¡ãC followed by the addition of Et3N (1. mL, 11.9 mmol) and acetyl imidazole (0.68 g, 6.2 mmol). The mixture was warm spontaneously over night. The CH2Cl2 was removed in vacuo and the residue dissolved in EtOAc (100 mL) and washed with 1N HC1 (2 x 30 mL), NaHC03 (1 x 30 mL), brine, dried over Na2SO4, and conc. in vacuo to yield 2. 5 g (92percent) of the title compound as a light yellow solid.

The synthetic route of 1-(1H-Imidazol-1-yl)ethanone has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ELAN PHARMACEUTICALS, INC.; PHARMACIA & UP JOHN COMPANY; WO2005/95326; (2005); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem