Category: 24134-65-4

Related Products of 24134-65-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 24134-65-4 as follows.

A solution of lambda/-methyl-lambda/-[2-(methylamino)ethyl]- 3,4-bis(methyloxy)benzenesulfonamide (50 mg; 0.17 mmol), prepared as Example 10a, and DIEA (43 uL; 0.25 mmol) in 2 mL of DCM was treated with 1 ,3-dimethyl-2- oxo-2,3-dihydro-1 /-/-benzimidazole-5-sulfonyl chloride (47 mg; 0.18 mmol). The solution was capped under nitrogen and stirred at room temperature overnight. The reaction was diluted to 10 mL with DCM and washed once each with 1 M NaHSO4, water, and sat’d aq. NaHCO3. The organic phase was dried over Na2SO4 and concentrated in vacuo to give 87 mg of the title compound as white amorphous solid. 92% purity by HPLC. LCMS (M+H = 513). 1 H NMR (DMSO-d6) delta 7.49 (m, 2H), 7.32 (m, 2H), 7.14 (m, 2H), 3.82 (s, 3H), 3.80 (s, 3H), 3.38 (s, 3H), 3.36 (s, 3H), 3.07 (bs, 4H), 2.67 (s, 3H), 2.66 (s, 3H).

According to the analysis of related databases, 24134-65-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/127505; (2007); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 24134-65-4, name is 1,3-Dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-sulfonyl chloride, A new synthetic method of this compound is introduced below., Application In Synthesis of 1,3-Dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-sulfonyl chloride

Take 1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo [d] imidazole-5-sulfonyl chloride (0.5 g, 1.9 mmol),(1-benzylpiperidin-4-yl) methylamine (0.4 g, 1.9 mmol),Triethylamine (0.4g, 3.8mmol) was added to the eggplant-shaped bottle, and then dichloromethane was added, and the reaction was performed at room temperature for 6 hours;After the reaction, add water, wash with brine 3 times, spin dry, and pass through the column.A white solid was obtained with a yield of 76%.TLC detected one point, there was fluorescence at 254nm and no fluorescence at 365nm.

The synthetic route of 24134-65-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; China Pharmaceutical University; Sun Haopeng; Mo Jun; Li Qihang; Yang Hongyu; Chen Yao; Chen Tingkai; Li Qi; Guo Yan; Liu Zongliang; Feng Feng; Liu Wenyuan; (19 pag.)CN110776494; (2020); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem