Category: 2301-25-9

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2301-25-9, name is 1-(4-Nitrophenyl)-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., category: imidazoles-derivatives

(2-1) Take 5.07g (27mmol) of intermediate I into a 500mL round bottom flask with magnetons, add 350mL of ethanol, and put it into the collector type constant temperature heating magnetic stirrer, stir and stir to make the intermediate I completely dissolved; (2-2) Further, 0.12 g of palladium carbon was slowly added thereto, and the mixture was thoroughly mixed with the reaction liquid, and then hydrazine hydrate was added in three portions, each time 20.67 mmol (1 mL), a total of 3 mL (62 mmol), and the reaction was carried out for 6 hours, using a thin layer. Chromatographic TLC tracking detection; (2-3) The reaction is terminated, cooled and filtered, and then steamed to 25-30 mL, placed in a fume hood, heated to dryness to 15 mL of a white solid, and dried; (2-4) 40 mL of distilled water was added, and the mixture was stirred at normal temperature for 3 hours to remove hydrazine hydrate, suction filtered, and dried to give 3.88 g of white Intermediate II pure product, yield 91%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2301-25-9.

Reference:
Patent; Fuyang Normal College; Liu Jie; Yang Chao; Zhou Ziyao; Wu Hai; Li Huiquan; (17 pag.)CN109206370; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 2301-25-9, These common heterocyclic compound, 2301-25-9, name is 1-(4-Nitrophenyl)-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

10.0 g of 4-(imidazole-1-yl)nitrobenzene were dissolved in 80 ml of acetic acid, and 35.1 g of anhydrous tin(II) chloride were subsequently added to the resultant solution. The solution was then stirred for 3 hours at 90-95 C. After cooling the solution reacted and removing the solvent used by distillation under reduced pressure, pH of the solution was adjusted to a range of from 9 to 11 with 10% aqueous solution of NaOH to extract the solution with chloroform. After dried the organic layer resulted with anhydrous magnesium sulfate, the solvent used was removed by distillation under reduced pressure, thereby affording 7.2 g of 4-(imidazole-1-yl)aniline.

Statistics shows that 1-(4-Nitrophenyl)-1H-imidazole is playing an increasingly important role. we look forward to future research findings about 2301-25-9.

Reference:
Patent; Nippon Soda Co., Ltd.; US5965743; (1999); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 2301-25-9, name is 1-(4-Nitrophenyl)-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2301-25-9, name: 1-(4-Nitrophenyl)-1H-imidazole

Part B. Preparation of 1-(3-cyanophenyl)-3-methyl-5-[(4′-(N-imidazolyl)phenyl)aminocarbonyl]pyrazole The product from part A was then coupled to 1-(3-cyanophenyl)-3-methylpyrazole-5-carboxylic acid via the acid chloride methodology described previously to afford the desired amide which was then purified via standard reverse phase HPLC techniques to afford the desired material. 1 H-NMR (DMSO-d6, 300 MHz) delta: 10.73 (s,1H) 9.35 (bs,1H) 8.13 (s,1H) 7.95 (s,1H) 7.90-7.60 (complex,8H) 7.0 (s,1H) 2.30 (s,3H) ppm; ESI mass spectrum analysis m/z (rel. intensity) 369 (m+H, 100); HRMS calc. mass 369.146384; found 369.145884.

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Reference:
Patent; DuPont Pharmaceuticals Company; US6020357; (2000); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2301-25-9, name is 1-(4-Nitrophenyl)-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 1-(4-Nitrophenyl)-1H-imidazole

General procedure: To a stirring solution of 4-CNPy (104 mg, 1.0 mmol, 2 equiv) in ethanol (25 ml), Ru(NO)Cl3·2H2O (136 mg, 0.5 mmol, 1 equiv) was added and contents of the flask heated under reflux for 12 h. After cooling to room temperature a red solid separated which was isolated by filtration, washed with ethanol, diethylether and dried under vacuo. Crystals suitable for X-ray diffraction analyses were obtained by slow diffusion of hexane into dichloromethane solution of the complex. Yield: 138 mg (62%),

The synthetic route of 2301-25-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kumar, Amit; Pandey, Rampal; Gupta, Rakesh Kumar; Ghosh, Kaushik; Pandey, Daya Shankar; Polyhedron; vol. 52; (2013); p. 837 – 843;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 2301-25-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2301-25-9 as follows.

YB112 (162mg) was dissolved in THF solvent. After the reaction system was deaerated,10% Pd / C 20mg was added.A hydrogen balloon was added to the reaction system, and the reaction was allowed to proceed overnight.The reaction was filtered and washed with ethyl acetate, concentrated, and the target product YB126 (154 mg) was purified on a silica gel column.

According to the analysis of related databases, 2301-25-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhao Yujun; Li Jia; Wang Zengtao; Zhang Shiyan; Zang Yi; Wang Peipei; Sun Dandan; Zhang Hanyan; (155 pag.)CN110818683; (2020); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Some common heterocyclic compound, 2301-25-9, name is 1-(4-Nitrophenyl)-1H-imidazole, molecular formula is C9H7N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C9H7N3O2

Step 5 4-(Imidazol-1-yl)aniline, dihydrochloride A mixture of 4-(imidazol-1-yl)nitrobenzene (89.60 g, 0.474 mol) and 10% palladium on carbon (4.50 g) in ethanol (1200 ml) and 5N HCl (189 ml) was hydrogenated in two batches at 40 psi for 80 minutes. Water (450 ml) was then added to dissolve the product and the catalyst was removed by filtration, washing with more water, and the combined filtrates were evaporated in vacuo, using finally a freeze drier, to give 105.4 g (96%) of the title compound as a cream solid. deltaH (250 MHz, D2 O) 7.22 (2H, d, J=8.8 Hz), 7.35 (1H, t, J=2.1 Hz), 7.44 (2H, d, J=9.0 Hz), 7.59 (1H, t, J=1.8 Hz), 8.89 (1H, t, J=1.5 Hz).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2301-25-9, its application will become more common.

Reference:
Patent; Merck Sharp & Dohme Ltd.; US6150391; (2000); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2301-25-9, name is 1-(4-Nitrophenyl)-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 1-(4-Nitrophenyl)-1H-imidazole

Part A. Preparation of 1-(4-aminophenyl)imidazole. 1-(4-Nitrophenyl)imidazole (5.0 g) and 200 mL of methanol were combined to form a solution at ambient temperature. The addition of a catalytic amount of 10% palladium on carbon turned the solution into a suspension. Placement of the reaction mixture under a hydrogen atmosphere initiated the reduction. The reaction proceeded overnight (15 h) at ambient temperature. Filtration through a celite pad separated out the catalyst. Concentration of the filtrate under reduced pressure gave the title product as a pale yellow solid (3.99 g). 1 H-NMR(DMSO d6) delta: 7.95 (s, 1H), 7.45 (s, 1H), 7.18 (d, 2H), 6.99 (s, 1H), 6.60 (d, 2H), 5.25 (s, 2H) ppm. LRMS(GC/MS) m/z 160 (M+H, 100).

The synthetic route of 2301-25-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DuPont Pharmaceuticals Company; US6020357; (2000); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 2301-25-9, A common heterocyclic compound, 2301-25-9, name is 1-(4-Nitrophenyl)-1H-imidazole, molecular formula is C9H7N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2. 4-(Imidazol-1-yl)aniline. Dihydrochloride. A mixture of 4-(imidazol-1-yl)nitrobenzene (89.60 g, 0.474 mol) and 10% palladium on carbon (4.50 g) in ethanol (1200 ml) and 5N HCl (189 ml) was hydrogenated in two batches at 40 psi for 80 minutes. Water (450 ml) was then added to dissolve the product and the catalyst was removed by filtration, washing with more water, and the combined filtrates were evaporated in vacuo, using finally a freeze drier, to give 105.4 g (96%) of the title compound as a cream solid. deltaH (250 MHz, D2 O) 7.22 (2H, d, J=8.8 Hz), 7.35 (1H, t, J=2.1 Hz), 7.44 (2H, d, J=9.0 Hz), 7.59 (1H, t, J=1.8 Hz), 8.89 (1H, t, J=1.5 Hz).

The synthetic route of 2301-25-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merck Sharp & Dohme, Ltd.; US5854268; (1998); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2301-25-9, name is 1-(4-Nitrophenyl)-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 1-(4-Nitrophenyl)-1H-imidazole

33.2 1-(4-aminophenyl)-1H-imidazole: 1-(4-nitrophenyl)-1H-imidazole (4.4 g; 23.5 mmoles) is put in solution in anhydrous methanol (140 ml) and palladium on carbon (0.44 g) is added to the medium. The reaction medium is placed under hydrogen for 4 hours. The catalyst is filtered off and the solvent is evapored to dryness. The expected product is obtained in a virtually pure state with a yield of 89% (3.3 g). NMR 1H (CDCl3, 100 MHz, delta): 6.61-6.69-6.95-7.05 (4s, 4H, Arom. H), 6.88 (t, 1H, Arom. H imidazole), 7.07 (s, 1H, Arom. H imidazole), 7.52 (s, 1H, Arom. H imidazole).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2301-25-9.

Reference:
Patent; Chabrier de Lassauniere, Pierre Etienne; Auvin, Serge; Bigg, Dennis; Auguet, Michel; Harnett, Jeremiah; US2003/78420; (2003); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

2301-25-9, name is 1-(4-Nitrophenyl)-1H-imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C9H7N3O2

Benzyl bromide (712 muIota_, 6 mmol) and 4-nitrophenylimidazole (222 mg, 1 .2 mmol.) were stirred in 10 ml of anhydrous THF under reflux for 45 h and under inert atmosphere. The precipitate was then filtered, washed with THF and dried under reduced pressure to give 393 mg (91 %) of 1-benzyl-3-(4-nitrophenyl)imidazolium bromide (Example 1) as an off white powder. 1H NMR (DMSO-d6, 400.13 MHz): delta 10.37 (t, 1 H, J = 1.5 Hz, N-CH-N), 8.57 (1 H, m, H(imidazolium backbone)), 8.55 (2H, m, H(nitrobenzyl)), 8.19 (1 H, m, H(imidazolium backbone)), 8.17 (2H, m, H(nitrophenyl)), 7.64-7.58 (2H, m, Hm(benzyl)), 7.52-7.43 (3H, m, Hp + Ho(benzyl)), 5.61 (2H, s, CH2). 13C NMR (DMSO-d6,100.16 MHz): delta 147.7 (carbene), 139.5, 134.4, 129.1 , 129.0, 128.9, 125.7, 123.7, 123.2, 121.8, 52.7 (CH2). MS (ES+) calcd for (M-Bn+H)+ 190.1 (100%), 191 .1 (1 1 %) (M-Br)+: 280.1 (100%), 281 .1 (18.7%), (2M-Br)+: 639.1 (100%), 641.1 (95%), 640.1 (36%), 642.1 (36%) Found (M- Bn+H)+ 190.0 (100%) (M-Br)+: 280.1 (100%), 280.8 (18.9%), (2M-Br)+: 639.0 (95 %), 641 .0(100%)

The synthetic route of 2301-25-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); CHU NANTES; UNIVERSITE DE NANTES; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S); FAIVRE-CHAUVET, Alain; RAJERISON, Holisoa; GESTIN, Jean-Francois; WO2013/171224; (2013); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem