Application of 221289-88-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 221289-88-9, name is 2-Oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows.
A solution of 3,4-diaminobenzonitrile (2.60 g, 18.2 mmol) and pyridine (2 mL, 25 mmol) in DMF (20 mL) was added a solution of bis(trichloromethyl)carbonate (2.12 g, 7.14 mmol) in tetrahydrofuran (20 mL) dropwise under ice-cooling. The mixture was stirred at room temperature for 18 h. Dilute hydrochloric acid was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with brine, dried and concentrated under reduced pressure. To the residue was added ethyl acetate, and then the precipitate was collected by filtration to give 2-hydroxybenzimidazole-5-carbonitrile (896 mg, 29%) as a purple solid. A mixture of the above compound (894 mg, 5.62 mmol) and phosphorus oxychloride (12 mL) was refluxed for 3 h. The reaction mixture was added to ice, and extracted with ethyl acetate. The extract was washed with brine, dried and concentrated under reduced pressure. The residue was purified by silica gel chromatography with n-hexane/ethyl acetate (2:3, v/v) to give the title compound (322 mg, 32%) as a white powder. LC-MS (ESI) m/z 178.0 [M+H]+.
The chemical industry reduces the impact on the environment during synthesis 2-Oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carbonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Article; Yoshida, Tomohiro; Akahoshi, Fumihiko; Sakashita, Hiroshi; Sonda, Shuji; Takeuchi, Masahiro; Tanaka, Yoshihito; Nabeno, Mika; Kishida, Hiroyuki; Miyaguchi, Ikuko; Hayashi, Yoshiharu; Bioorganic and Medicinal Chemistry; vol. 20; 16; (2012); p. 5033 – 5041;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem