Electric Literature of 214147-60-1, These common heterocyclic compound, 214147-60-1, name is tert-Butyl 2-chloro-1H-benzo[d]imidazole-1-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step B: 2-(2, 6-Dimethyl-phenoxy)-lH-benzoimidazole; Cesium carbonate (2.643 g, 8. 112 mmol) was added to a solution of 2-chloro- benzoimidazole-l-carboxylic acid tert-butyl ester (1.000 g, 3.957 mmol) and 2,6- dimethylphenol (3. 867 g, 31.66 mmol) in isopropanol (10 mL). The mixture was heated at 150 C for 22 h and then cooled to room temperature. The reaction mixture was partitioned between ethyl acetate and 2.0 N sodium hydroxide solution. The aqueous phase was separated and extracted with ethyl acetate and dichloromethane. The combined organic phases were washed with brine, dried over anhydrous magnesium sulfate, filtered, and concentrated to afford an orange-brown solid. Trituration with dichloromethane and filtering afforded 2- (2, 6-dimethyl- phenoxy)-lH-benzoimidazole as an off-white solid. MS (MH+) 239.2 ; Calculated 238.11 forCl5Hl4N2O.
The synthetic route of 214147-60-1 has been constantly updated, and we look forward to future research findings.