Category: 21343-04-4

Brown, Tom published the artcilePurines, pyrimidines, and imidazoles. Part 51. New syntheses of some 5-alkyl- and 5-dialkylaminoimidazoles. 3-Alkylimidazolium nucleosides and 3-alkylpurines, Recommanded Product: 5-Amino-1-methyl-1H-imidazole-4-carboxamide, the main research area is imidazolium nucleoside; purine alkyl; Dimroth rearrangement methylaminoimidazolecarboxlate.

The α- and β-anomers of the imidazolium nucleoside I (R = H, R12 = CMe2, R2 = Et) and the β-anomers of I (R = H, R12 = CMe2, R2 = CH2Ph; R = R1 = Ac, R2 = CH2Ph) were prepared by methylation of the corresponding nucleosides with MeI. Their reactions with acids and bases were examined The imidazolecarboxlates II (R = OEt, R1 = H, R2 = Me, CH2Ph) were prepared from EtOC(:NH)CH2CO2Et by substitution with R2NHMe followed by reaction with diazotized PhNH2, reductive formylation, and cyclization. Catalytic hydrogenation of II (R = OEt, R1 = H, R2 = CH2Ph) gave II (R = OEt, R1 = R2 = H) which was converted into 3-methylhypoxanthine ( III; R = H), 3-methylguanine (III; R = NH2), and, by Dimroth rearrangement with aqueous NH3, to II (R = NH2, R1 = Me, R2 = H).

Journal of the Chemical Society, Perkin Transactions 5: Organic and Bio-Organic Chemistry published new progress about Nucleosides Role: SPN (Synthetic Preparation), PREP (Preparation). 21343-04-4 belongs to class imidazoles-derivatives, name is 5-Amino-1-methyl-1H-imidazole-4-carboxamide, and the molecular formula is C5H8N4O, Recommanded Product: 5-Amino-1-methyl-1H-imidazole-4-carboxamide.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Panzica, Raymond P. published the artcileAnalogs of AICA- and iso-AICA ribosides and their methylated base counterparts, Application In Synthesis of 21343-04-4, the main research area is imidazole thiocarboxamide selenocarboxamide riboside preparation kinetics; AICA riboside analog preparation reaction kinetics.

A mild, convenient and efficient synthesis has been developed for imidazole-4-thiocarboxamide and imidazole-5-thiocarboxamide ribosides and the analogous selenocarboxamides. This methodol., i.e., DMF saturated with H2S or H2Se, also converts the corresponding N-methylated bases to the corresponding amides. The imidazole-4(5)-selenocarboxamides were shown to be sensitive to base (pH 11) and were easily converted back to their cyano precursors. The kinetics of these reactions were determined and they indicate that the C5 amides were more reactive than their C4 analogs.

Nucleosides & Nucleotides published new progress about Reaction kinetics. 21343-04-4 belongs to class imidazoles-derivatives, name is 5-Amino-1-methyl-1H-imidazole-4-carboxamide, and the molecular formula is C5H8N4O, Application In Synthesis of 21343-04-4.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem