21252-69-7 Archives - Page 3 of 4 - Imidazoles-derivatives

D’Anna, Francesca et al. published their research in ChemPlusChem in 2013 | CAS: 21252-69-7

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Electric Literature of C11H20N2

The Gelling Ability of Some Diimidazolium Salts: Effect of Isomeric Substitution of the Cation and Anion was written by D’Anna, Francesca;Vitale, Paola;Ferrante, Francesco;Marullo, Salvatore;Noto, Renato. And the article was included in ChemPlusChem in 2013.Electric Literature of C11H20N2 This article mentions the following:

The gelling ability of some geminal imidazolium salts was studied both in organic solvents and in water solution Organic salts differing either in the cation or anion structure were taken into account. In particular, the effects on the gel-phase formation of isomeric substitution on the cation or anion and of the use of mono- or dianions were evaluated. As far as the cation structure is concerned, isomeric cations, such as 3,3′-di-n-octyl-1,1′-(1,4-phenylenedimethylene)diimidazolium and 3,3′-di-n-octyl-1,1′-(1,3-phenylenedimethylene)diimidazolium, were used. However, in addition to the bromide anion, isomeric dianions, such as the 1,5- and 2,6-naphthalenedisulfonate anions, were also examined After preliminary gelation tests, different factors affecting the obtained gel phases, such as the nature of the solvent, organogelator concentrations, and action of external stimuli, were analyzed. The gel-phase formation was also studied as a function of time, by using resonance light scattering measurements. Gel morphologies were analyzed by SEM. To further support the understanding of the different behavior shown by the isomeric cations, some representative ion pairs were analyzed by DFT-based studies. The collected data underline the significant role played by isomeric substitution of both cation and anion structures in determining the gelling capability of the studied salts, as well as the properties of the gel phases. Finally, DFT studies were helpful in the identification of the structural features affecting the self-assembly. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Electric Literature of C11H20N2).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hosseini-Eshbala, Fereshteh et al. published their research in Materials Science & Engineering, C: Materials for Biological Applications in 2020 | CAS: 21252-69-7

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Computed Properties of C11H20N2

Ionic-liquid-modified CMK-3 as a support for the immobilization of molybdate ions (MoO₄^2-): Heterogeneous nanocatalyst for selective oxidation of sulfides and benzylic alcohols was written by Hosseini-Eshbala, Fereshteh;Sedrpoushan, Alireza;Breit, Bernhard;Mohanazadeh, Farajollah;Veisi, Hojat. And the article was included in Materials Science & Engineering, C: Materials for Biological Applications in 2020.Computed Properties of C11H20N2 This article mentions the following:

A nanometric carbon CMK-3 modified with octylimidazolium ionic liquid (OctIm) and MoO₄^2- as a new hybrid catalyst was synthesized. The study is the first to report a successful immobilization of MoO₄^2- on the CMK-3/OctIm as a hybrid nanocatalyst. A variety of anal. methods were utilized to determine the properties of the structure and morphol. of the synthesized nanocatalyst [CMK-3/OctIm/ MoO₄^2-]. The anal. techniques were transmission electron microscopy (TEM), scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS), inductively coupled plasma (ICP), X-ray diffraction (XRD), N₂ isotherms (BET), IR spectroscopy and thermogravimetric anal. (TGA). CMK-3/OctIm/ MoO₄^2- hybrid catalyst demonstrated a considerable catalytic activity. It is a recyclable nanocatalyst that is utilized to chemoselectively oxidize different types of sulfides RSR¹ (R = Me, Ph, prop-2-en-1-yl, etc.; R¹ = Me, Ph, cyanomethyl, etc.) and thianthrene to the corresponding sulfoxides RS(O)R¹ and thianthrene,5,10-dioxide and benzylic alcs. R²CH₂OH (R² = Ph, 3,4,5-trimethoxyphenyl, 3-chlorophenyl, etc.) to aldehydes R²CHO using the green oxidant, hydrogen peroxide (H₂O₂) in high-yields. With a little leaching and variation in activity, it is possible to recover and reuse the catalyst frequently. A combination of molybdate anion and the CMK-3 order mesoporous carbon resulted in an improvement in the performance of catalysis and ease of separation for the reaction procedure. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Computed Properties of C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Computed Properties of C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chai, Mingfeng et al. published their research in Journal of Surfactants and Detergents in 2014 | CAS: 21252-69-7

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.COA of Formula: C11H20N2

CO₂/N₂ Triggered Switchable Surfactants with Imidazole Group was written by Chai, Mingfeng;Zheng, Zhibo;Bao, Lei;Qiao, Weihong. And the article was included in Journal of Surfactants and Detergents in 2014.COA of Formula: C11H20N2 This article mentions the following:

In order to overcome the hydrolysis of 2-alkyl-1-hydroxyethyl imidazoline and its unsatisfactory emulsification-demulsification switchability to water-alkane, the long-chain N-alkylimidazole compounds were synthesized by n-octyl bromide, n-decyl bromide, n-dodecyl bromide, n-tetradecyl bromide and n-hexadecyl bromide with imidazole, resp. and characterized by MS, ¹H NMR and FTIR. The long-chain N-alkylimidazole compounds can be reversibly transformed into charged surfactants by exposure to CO₂. Surface tension values indicated that N-alkylimidazolium bicarbonates had excellent surface activity compared with corresponding conventional surfactants with a lower γ_CMC. The surface behaviors of the five surfactants can be illustrated by A_min. Five conductivity cycles by bubbling CO₂ and N₂ alternately indicated that these surfactants could be switched by CO₂ reversibly and repeatedly. Emulsions were repeatedly stabilized for five cycles by N-alkylimidazolium bicarbonate and broken by bubbling N₂ through the solutions to reverses the reaction, releasing CO₂. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7COA of Formula: C11H20N2).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hallett, Andrew J. et al. published their research in Dalton Transactions in 2018 | CAS: 21252-69-7

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Related Products of 21252-69-7

Exploring the cellular uptake and localisation of phosphorescent rhenium fac-tricarbonyl metallosurfactants as a function of lipophilicity was written by Hallett, Andrew J.;Placet, Emeline;Prieux, Roxane;McCafferty, Danielle;Platts, James A.;Lloyd, David;Isaacs, Marc;Hayes, Anthony J.;Coles, Simon J.;Pitak, Mateusz B.;Marchant, Sarah;Marriott, Stephen N.;Allemann, Rudolf K.;Dervisi, Athanasia;Fallis, Ian A.. And the article was included in Dalton Transactions in 2018.Related Products of 21252-69-7 This article mentions the following:

A systematic study of the cellular uptake of emissive complexes as a function of their lipophilicity is presented. Here a series of amphiphilic rhenium fac-tricarbonyl bisimine complexes bearing axial substituted imidazole or thiazole ligands, [Re(bpy)(CO)₃(ImC_nH_m)]⁺ {n = 1 m = 3 (1⁺), n = 4 m = 9 (2⁺), n = 8 m = 17 (3⁺), n = 12 m = 25 (4⁺), n = 16 m = 33 (5⁺), n = 2 m = 3 (6⁺); bpy = 2,2′-bipyridine, Im = imidazole} and [Re(bpy)(CO)₃(L)]⁺ {L = 1-mesitylimidazole, ImMes (7⁺), 4,5-dimethylthiazole, dmt (8⁺) and 4-methyl-5-thiazole-ethanol, mte (9⁺)} is reported. The X-ray crystal structures of 2⁺, 8⁺ and 9⁺ confirm the geometry and expected distribution of ligands and indicated that the plane of the imidazole/thiazole ring is approx. parallel to the long axis of the bipy ligand. Luminescence studies revealed excellent properties for their use in cell imaging with visible excitation and broad emission profiles. Their uptake in two distinct species has been examined by fluorescence imaging of the diplomonad fish parasite Spironucleus vortens (S. vortens) and rod-shaped yeast Schizosaccharomyces pombe (Schiz. pombe) as a function of their lipophilicity. The uptake of the complexes was highest for the more lipophilic 2⁺-5⁺ in both S. vortens and Schiz. pombe in which the long alkyl chain aids in crossing bilipid membranes. However, the increased lipophilicity of longer chains also resulted in greater toxicity. Localization over the whole cell varied with differing alkyl chain lengths with complex 2⁺ preferentially locating to the nucleus of S. vortens, 3⁺ showing enhanced nuclear partitioning in Schiz. pombe, and 4⁺ for the remaining cell wall bound in the case of S. vortens. Interestingly, complexes of intermediate lipophilicity such as 7⁺ and 8⁺ showed reasonable uptake, proved to be non-toxic, and were capable of crossing exterior cell walls and localising in the organelles of the cells. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Related Products of 21252-69-7).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

27-Sep-2021 News New downstream synthetic route of 21252-69-7

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 21252-69-7, name is 1-Octyl-1H-imidazole, A new synthetic method of this compound is introduced below., COA of Formula: C11H20N2

General procedure: A solution of 1,3-dibromo-2-propyl glycoside 2 (1 mmol) and thealkylated imidazole 3 (6 mmol) in xylene (2 mL) was heated to 125 °C for 2 h. The solvent was evaporated before the crude product wastaken up in MeCN (10 mL) and extracted 4 times with hexane (60 mL) to remove remaining imidazole 3. The acetonitrile phase was concentrated under reduced pressure to provide the desired product 4 as pale yellow syrup in yields higher than 90percent.

Reference:
Article; Salman, Abbas Abdulameer; Goh, Ean Wai; Heidelberg, Thorsten; Hussen, Rusnah Syahila Duali; Ali, Hapipah Mohd; Journal of Molecular Liquids; vol. 222; (2016); p. 609 – 613;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Some scientific research about 21252-69-7

The chemical industry reduces the impact on the environment during synthesis 1-Octyl-1H-imidazole. I believe this compound will play a more active role in future production and life.

Application of 21252-69-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 21252-69-7, name is 1-Octyl-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A solution of 2-bromoethyl glucoside 2 (1.1 mmol) and the alkylated imidazole 4 (3.3 mmol) in xylene (2 mL) was heated to 125 °C for 1 h. The solvent was evaporated and the crude product was taken up in MeCN (10 mL) and extracted 4 times with hexane (60 mL) to remove remaining imidazole 4. The acetonitrile phase was concentrated under reducing pressure to provide the desired product 5 as a pale yellow syrup in ~95percent yield.

The chemical industry reduces the impact on the environment during synthesis 1-Octyl-1H-imidazole. I believe this compound will play a more active role in future production and life.

Reference:
Article; Salman, Abbas Abdulameer; Tabandeh, Mojtaba; Heidelberg, Thorsten; Hussen, Rusnah Syahila Duali; Ali, Hapipah Mohd; Carbohydrate Research; vol. 412; (2015); p. 28 – 33;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Discovery of C11H20N2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Octyl-1H-imidazole, its application will become more common.

Related Products of 21252-69-7,Some common heterocyclic compound, 21252-69-7, name is 1-Octyl-1H-imidazole, molecular formula is C11H20N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Dicationic imidazolium ionic liquids were prepared by refluxing-N-hexadecylimidazole (5.85 g, 20 mmol) and 1,4-dibromobutane (2.16 g, 10 mmol) in isopropanol (50 mL) at 80 °C for 24 h. Then, the products were washed with diethyl ether four times under vacuum.

Reference:
Article; Wu, Jianghao; Jiang, Pingping; Qin, Xiaojie; Ye, Yuanyuan; Leng, Yan; Bulletin of the Korean Chemical Society; vol. 35; 6; (2014); p. 1675 – 1680;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The important role of 21252-69-7

According to the analysis of related databases, 21252-69-7, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 21252-69-7 as follows. Recommanded Product: 21252-69-7

General procedure: To a screw capped tube flask,chloroalkylated quaternary ammonium salt 2 and 5 equivalents of alkyl imidazole 3 were added with acetonitrile (5 ml). The sealed flask was heated at 100 for 24h. After the solvent was removed by evaporation, the residue was dissolved in a small amount of dichloromethane. The solution was poured into ethyl acetate, anoily imidazolium salt was separated from an organic phase. In case of 4ao, it was recrystallized in ethylacetate. Salt 4 was also moisture-sensitive as 2.

According to the analysis of related databases, 21252-69-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Cho, Beom Shin; Jung, Il Gu; Chung, Young Keun; Han, Jin Wook; Bulletin of the Korean Chemical Society; vol. 36; 2; (2015); p. 451 – 452;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A new synthetic route of 21252-69-7

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Octyl-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 21252-69-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 21252-69-7, name is 1-Octyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A solution of 3-tert-butyl-5-bromomethyl-2-hydroxybenzaldehyde [46,47] in toluene (5.0 mL) was addeddropwise to a solution of N-alkylimidazole (10.0 mmol) in toluene(20.0 mL) over 10 min at room temperature. The mixture was thenheated to reflux for 5 h. After cooling to room temperature, the pre-cipitate product was filtered, washed with toluene (3 × 5 mL) anddried under reduced pressure.

Reference:
Article; Duan, Shuhui; Jing, Xinyao; Li, Dandan; Jing, Huanwang; Journal of Molecular Catalysis A: Chemical; vol. 411; (2016); p. 34 – 39;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Discovery of 21252-69-7

The synthetic route of 1-Octyl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Reference of 21252-69-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 21252-69-7, name is 1-Octyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a three-necked flask equipped with a stirrer and a thermometer, 1.44 g (8.0 mmol) of N-octylimidazole, 0.56 g (4.4 mmol) 1,3-dichloro-2-propanol, stirring at 115 ° C ~ 125 ° C reaction, TLC follow the progress of the reaction, about 8 ~ 12h after the end of the reaction. The crude product was recrystallized from a mixed solvent of chloroform and ethyl acetate, A white powdery solid was obtained 1,1 ‘-dioctyl-3,3′(2-hydroxy-1,3-propylene) imidazole hydrochloride (1.02 g, yield 52.1percent).

The synthetic route of 1-Octyl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Qiqihar university; Wang, LiYan; Deng, QiGang; Zheng, YongJie; Huo, shichao; Liu, Jia; Sun, zhu; (10 pag.)CN103951702; (2016); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem