Category: 21252-69-7

Synthesis and biological study of acridine-based imidazolium salts was written by Sharhan, Olla;Heidelberg, Thorsten;Hashim, Najiahah Mohd;Salman, Abbas Abdulameer;Ali, Hapipah Mohd;Jayash, Soher Nagi. And the article was included in RSC Advances in 2018.Name: 1-Octyl-1H-imidazole This article mentions the following:

A new series of acridine based imidazolium salts was synthesized and evaluated for in vitro cytotoxicity against human cancer cell lines by an MTT assay. The synthesis applied a coupling of imidazoles with 9-chloroacridines, which originated from an Ullmann condensation of a 2-chloro-benzoic acid with an aniline. The target compounds were obtained in high yields. The DPPH assay indicated considerable antioxidant activity for target compounds with simple and short alkyl chains on the imidazole, while increasing chain length and the introduction of an addnl. ϖ-electron system in most cases reduced the activity. All compounds exhibited low biotoxicity against non-cancerous cell lines, whereas a few compounds showed promising anticancer activity. Unlike for the reference drugs Tamoxifen and Paclitaxel, the anticancer activity of acridine imidazolium ions is specific for only selected cancer types. Reasonable fluorescent behavior of the products provide potential for visualization of the distribution of active drugs in tissue. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Name: 1-Octyl-1H-imidazole).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Name: 1-Octyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Study on properties of N,N’-dialkyl imidazole ionic liquid surfactant was written by Wang, Li-yan;Sun, Zhu;Yu, Ting-ting;Zhao, Bing;Li, Kuo. And the article was included in Yinran Zhuji in 2013.Electric Literature of C11H20N2 This article mentions the following:

Intermediates N-octyl imidazole was synthesized from imidazole and bromooctane. N,N’-dialkyl imidazole ionic liquid surfactants were synthesized from bromoalkanes (bromooctane, bromodecane, bromo-dodecane, bromotetradecane and bromohexadecane) and N-octyl imidazole under the assistance of ultrasound. The intermediate and target product were characterized by ¹H-NMR. The sterilization, surface tension, foaming properties and emulsifying properties of N,N’-dialkyl imidazole ionic liquid surfactants were determined The results showed that N,N’-dialkyl imidazole ionic liquid surfactants can inhibit the growth of Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Penicillium when the concentration of products were above 500 mg/L, and the greater the concentration, the better the anti-bactericidal performance. N,N’-dialkyl imidazole ionic liquid surfactants can reduce the surface tension of aqueous solution which reduced with the concentration increasing. With alkyl chain increasing, the foaming property and foam stability of N,N’-dialkyl imidazole ionic liquid surfactants increased first and then decreased. Using benzene as the oil phase, with alkyl chain increasing, the emulsifying ability of N,N’-dialkyl imidazole ionic liquid surfactants increased first and then decreased. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Electric Literature of C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Electric Literature of C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis, In silico and in vitro studies of Silver(I)-N-heterocyclic carbene complexes was written by Sarfraz, Ayesha;Ashraf, Rizwan;Ali, Shaukat;Taskin-Tok, Tugba;Khalid, Zohra;Ullah, Sana;Kahlid, Talha;Mushtaq, Muhammad;El-Bahy, Salah M.;El-Bahy, Zeinhom M.. And the article was included in Journal of Molecular Structure in 2022.SDS of cas: 21252-69-7 This article mentions the following:

In the present study, four silver based NHC (N-heterocyclic carbene) complexes (1c–4c) were designed and synthesized from their precursor salts (1b–4b). The successful synthesis of salts and complexes was assured through spectroscopic techniques (UV-visible, FTIR, ¹H NMR) as well as mass spectrometry. The in silico ADMET study and mol. docking calculations predicted the compounds are good drug candidates having therapeutic potential against multiple cancer targets including COX-1, VEGFA, HIF as well as VGF. Results of in vitro study conducted through MTT assay confirmed that all test compounds have concentration dependent potency but silver complexes (1c–4c) have far superior activity than precursor, salts (1b–4b) and slightly lower than standard drugs (carboplatin and cisplatin) against various cancer cell lines. Among the studied compounds, 3c showed lowest IC₅₀ value of 0.981 卤 0.09, 1.10 卤 0.14 and 0.973 卤 0.12渭g/mL against MCF-7, HCT-116 and A549 resp. The test compounds were found good antibacterial agents, when screened against bacterial strains (Staphylococcus aureus, Micrococcus luteus, Escherichia coli and S. typhimurium), as well as antioxidant agents when tested against DPPH free radicals. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7SDS of cas: 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.SDS of cas: 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Printable biflourene based ultra-violet (UV) organic light-emitting electrochemical cells (OLECs) with improved device performance was written by Arumugam, Sasikumar;Li, Yi;Pearce, James E.;Court, Katie L.;Piana, Giacomo;Jackman, Edward H.;Ward, Oliver J.;Charlton, Martin D. B.;Tudor, John;Harrowven, David C.;Beeby, Steve P.. And the article was included in Organic Electronics in 2022.Electric Literature of C11H20N2 This article mentions the following:

A series of printable UV emitting ionic bifluorene derivatives have been prepared incorporating pendent alkylimidazolium groups. Herein, we detail the synthesis of compounds and the methods used in device fabrication. We show how ink formulation is improved by increasing the solubility of the active bifluorene through extension of the alkyl chain length and switching the counter ion from PF^–₆ to CF₃SO^–₃. We also show how organic light emitting electrochem. cells (OLECs) can be fabricated by spray coating to achieve an active layer with a thickness of 鈭?50-200 nm, leading to working devices with a turn on voltage of around 6.5 V. This gives electroluminescent (EL) that peaks between 385 nm and 390 nm with a maximum EL emission intensity of 1.29 渭W/cm². Thus, EL emission within the UV range has been demonstrated successfully with the synthesized mols. via spray coating onto glass slides. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Electric Literature of C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Electric Literature of C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dialkylimidazolium dimethyl phosphates as solvents and catalysts for the Knoevenagel condensation reaction was written by Zicmanis, Andris;Anteina, Liene. And the article was included in Tetrahedron Letters in 2014.Reference of 21252-69-7 This article mentions the following:

The reaction between benzaldehyde and Et cyanoacetate is investigated in 1,3-dialkylimidazolium salts as solvents. The impact of both ions in these ionic liquids on the yield of the condensation reaction product is examined Potentiometric titrations are employed for quant. anal. of the best ionic liquids, revealing these to be 1,3-dialkylimidazolium di-Me phosphates. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Reference of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Reference of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Investigation on the Coordination Mode of IL-Supported Diols Used as Phosphine-Free Ligands for Palladium Catalyzed Heck Reaction was written by Cai, Yueqin;Song, Gonghua;Chen, Xiao. And the article was included in Chinese Journal of Chemistry in 2013.COA of Formula: C11H20N2 This article mentions the following:

The coordination mode of IL-supported diols used as phosphine-free ligands for palladium catalyzed Heck reaction was investigated by tuning their compositions The difference in coordination of these IL-supported diols with metal Pd in Heck reaction was related to the changes of the cation rings, leading to the different activities of Pd catalyst in the reaction. The exptl. results indicated that the activities of Pd catalyst were affected mainly by 蟺-electron d. of the cation rings. Compared to pyridinium and piperidinium cations, imidazolium cations showed the best coordination to metal Pd. In the meantime, C-2 hydrogen and the length of alkyl side chains had impacts on the coordination as well. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7COA of Formula: C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.COA of Formula: C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Amphiphilic multi-charged cyclodextrins and vitamin K co-assembly as a synergistic coagulant was written by Li, Pei-yu;Chen, Yong;Chen, Chang-hui;Liu, Yu. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Computed Properties of C11H20N2 This article mentions the following:

Balancing and neutralizing heparin dosing after surgeries and hemodialysis treatment is of great importance in medical and clin. fields. In this study, a series of new amphiphilic multi-charged cyclodextrins (AMCD)s as anti-heparin coagulants were designed and synthesized. The AMCD assembly was capable of selective heparin binding through multivalent bonding and showed a better neutralizing effect towards both unfractionated heparin and low mol. weight heparin than protamine in plasma. Meanwhile, an AMCD and vitamin K (VK) co-assembly was prepared to realize heparin-responsive VK release and provide a novel VK deficiency treatment for hemodialysis patients. This AMCD-VK co-assembly for heparin neutralization & vitamin K supplementation synergistic coagulation represents a promising candidate as a clin. anti-heparin coagulant. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Computed Properties of C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Computed Properties of C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Editors’ choice-the effect of anchor group and alkyl backbone chain on performance of organic compounds as corrosion inhibitors for aluminum investigated using an integrative experimental-modeling approach was written by Milosev, I.;Zimerl, D.;Carriere, Ch.;Zanna, S.;Seyeux, A.;Iskra, J.;Stavber, S.;Chiter, F.;PoberZnik, M.;Costa, D.;Kokalj, A.;Marcus, P.. And the article was included in Journal of the Electrochemical Society in 2020.COA of Formula: C11H20N2 This article mentions the following:

An alk. etched, superhydrophilic Al surface was modified using functionalized alkyl compounds selected to study the effect of their properties on adsorption on the metal surface. The thirteen organic compounds differed in alkyl chain length (eight and eighteen C atoms) and anchor group (azide, imidazole, thiocyanate, amino, disulfide, thiol, phosphonic, carboxylic, and benzoic). The methodol. of the study integrated a complete chain of steps incorporating synthesis, electrochem. and surface analyses, and computational modeling. The corrosion resistant and superhydrophobic properties depend on the anchor group, which governs adhesion to the surface, and backbone, which is responsible for lateral cohesive interactions. The morphol. and chem. composition of modified layers were studied using SEM, XPS and time-of-flight secondary ion mass spectrometry. Electrochem. and long-term immersion properties were studied in 0.5M NaCl. Calculations based on d. functional theory were performed as to model the adsorption of selected anchor groups on the hydroxylated oxidized Al surface. Integrated results allowed the identification of the anchor groups that are able to form inhibitive adsorbed layers on Al surface regardless the alkyl chain length, and those that are not able to form adsorbed layers at all and are thus not efficient corrosion inhibitors. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7COA of Formula: C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.COA of Formula: C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Systematic Investigation of a Surfactant Type Nano Gemini Ionic Liquid and Simultaneous Abnormal Salt Effects on Crude Oil/Water Interfacial Tension was written by Saien, Javad;Kharazi, Mona;Yarie, Meysam;Zolfigol, Mohammad Ali. And the article was included in Industrial & Engineering Chemistry Research in 2019.Quality Control of 1-Octyl-1H-imidazole This article mentions the following:

Gemini ionic liquids (ILs) are usually known to have significant surfactant behavior. Nanomaterials, on the other hand, are capable of improving interface properties. The current study explores the use of a novel nano gemini imidazolium IL with a mol. structure of a four methylene group spacer for reducing crude oil/water interfacial tension (IFT). The gemini IL was prepared purely by a two-step synthesis method and characterized in different ways. Results revealed that IFT was drastically decreased to 97.8% in the presence of the IL and more decrease was achieved with temperature and pH variations. The high performance of the IL can be attributed to the strong IL amphiphilic nature. The salt effects in the presence of the IL were evaluated with NaCl, MgCl₂, and their mixture Results revealed more IFT reduction under salinity conditions because of a remarkable found synergism effect, unlike conventional surfactants. The findings encourage the use of seawater IL solutions in chem. enhanced oil recovery. The obtained salt-free IFT data were precisely reproduced with the well-known Frumkin adsorption isotherm, and the corresponding thermodn. parameters were obtained at different temperatures From thermodn. results, a spontaneous IL adsorption was deduced. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Quality Control of 1-Octyl-1H-imidazole).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Quality Control of 1-Octyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cadmium(II) and lead(II) extraction and transport through polymer inclusion membranes with 1-alkylimidazole was written by Radzyminska-Lenarcik, Elzbieta;Pyszka, Ilona;Urbaniak, Wlodzimierz. And the article was included in Desalination and Water Treatment in 2021.COA of Formula: C11H20N2 This article mentions the following:

The formation of cadmium(II) complexes with hydrophobic 1-alkylimidazoles (1-hexylimidazole (1), 1-heptylimidazole (2), 1-octylimidazole (3), 1-decylimidazole (4) was tested by liquid-liquid partition method. On the basis of the extraction data, stability constants of cadmium(II) and Pb(II) complexes were determined It had been assumed that differences in the formation of cadmium(II) and lead(II) complexes with alkylimidazoles could be used to sep. those ions. The possibility of cadmium(II) and lead(II) ion separation in the transport through polymer inclusion membranes (PIMs) was examined PIMs comprising of cellulose triacetate, o-nitrophenylpentyl ether, and alkylimidazole (1-4) were used. The membranes were characterized using at. force microscopy (AFM). The results have shown that cadmium(II) ions are effectively transported through PIMs. The best result achieved for cadmium(II) removal from Cd(II)-Pb(II) solution for PIMs with (4) was 95.5% after 24 h. For this membrane, the separation coefficients for Cd(II)/Pb(II) were 1.62. Best Cd(II)/Pb(II) selectivity coefficients equal to 2.94 were found for (1). The influence of the basicity of carrier mols. on transport kinetics was discussed as well. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7COA of Formula: C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.COA of Formula: C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem