Category: 20970-50-7

Synthetic Route of 20970-50-7, The chemical industry reduces the impact on the environment during synthesis 20970-50-7, name is 1-(1-Methyl-1H-imidazol-5-yl)ethanone, I believe this compound will play a more active role in future production and life.

General procedure: nder an argon atmosphere, 9a (436 mg, 1.65 mmol) was dissolved in dry THF (30 mL) and the mixture was cooled to -65 C in a dry ice acetone bath. A n-BuLi hexane solution (1.6 M: 2.28 mL, 3.63 mmol) was added with stirring and the mixture was stirred at the same temperature for 1.5 h. After stirring, a solution of 6 (183 mg, 1.5 mmol) in dry THF (3 mL) was added dropwise and the whole was stirred at the same temperature for 1.5 h. After dilution with saturated aqueous ammonium chloride solution, the mixture was concentrated under reduced pressure. The resulting residue was dissolved in ethanol and the insoluble material was filtered off. The filtrate was concentrated under reduced pressure and the resulting residue was chromatographed on silica gel (CHCl3/7% ammonia in MeOH = 19:1) and crystallized from CHCl3 and diethylether to give 3c (121 mg, 26%) as a colorless powder.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(1-Methyl-1H-imidazol-5-yl)ethanone, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ruchelman, Alexander L.; Man, Hon-Wah; Chen, Roger; Liu, Wei; Lu, Ling; Cedzik, Dorota; Zhang, Ling; Leisten, Jim; Collette, Alice; Narla, Rama Krishna; Raymon, Heather K.; Muller, George W.; Bioorganic and Medicinal Chemistry; vol. 19; 21; (2011); p. 6356 – 6374;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 20970-50-7, A common heterocyclic compound, 20970-50-7, name is 1-(1-Methyl-1H-imidazol-5-yl)ethanone, molecular formula is C6H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[2516] Dissolve 365 (0.24 g, 0.49 mmol) in THF (2.5 ml). Cool under N2 to -78 C., add (1) (BuLi, 2.5M, 0.2 ml) and stir the resulting dark brown solution for 15 minutes. Dissolved 883 (0.116 g) from Step C in 0.5 mL of THF and add to reaction and stir at -78 C. for 3 hours. Add reaction mixture to brine and extract with ethyl acetate(2×). Dry with MgSO4, filter and evaporate to obtain a yellow solid. Purified crude (0.29 g) by Prep Plate Chromatography to afford 0.0.15 g, 42% yield of the desired product (795.1).

The synthetic route of 20970-50-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Schering Corporation; US2004/122018; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 20970-50-7, name is 1-(1-Methyl-1H-imidazol-5-yl)ethanone, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20970-50-7, Safety of 1-(1-Methyl-1H-imidazol-5-yl)ethanone

EXAMPLE 3 2-Benzyl-4-(1′-methyl-5′-imidazolyl)thiazole hydrochloride A solution of 5-acetyl-1-methylimidazole (100 mg, 0.81 mmol) in 2.4 ml of acetic acid was stirred at 25 C. as 0.24 ml (0.30 g, 1.2 mmol) of 31% hydrobromic acid in acetic acid was added. Pyridinium bromide perbromide (0.29 g, 0.91 mmol) was added, giving an orange solution from which a yellow precipitate formed after 30 minutes. After 2.5 hours, ether (5 ml) was added. The supernatant was removed by pipet, and the precipitate was dried under a stream of nitrogen. Ethanol (6 ml) and benzylthioamide (137 mg, 0.91 mmol) were added, and the mixture was heated to reflux for 45 minutes. The reaction was cooled to 25 C., poured into 25 ml of ether, and washed with 50 ml of 1.25N aqueous sodium hydroxide. The aqueous layer was extracted with 2*25 ml of ether, and the organic extracts were combined, dried (sodium sulfate), filtered, and evaporated. The residue was purified by column chromatography on silica gel (5 g), eluted with 8% isopropanol in 4:1 dichloromethane/ethyl acetate, yielding 2-benzyl-4-(1′-methyl-5′-imidazolyl)thiazole (159 mg, 77% yield) as an almost colorless oil. The free base (159 mg, 0.62 mmol) was dissolved in 10 ml of methanol and treated with 0.32 ml (0.64 mmol) of 2.0N aqueous hydrochloric acid. Evaporation of the solution yielded 183 mg of pale yellow crystals. Recrystallization from 2:1 ethyl acetate/ethanol gave 2-benzyl-4-(1′-methyl-5′-imidazolyl)thiazole hydrochloride (111 mg, 61% recovery) as colorless plates, m.p. 191-194 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(1-Methyl-1H-imidazol-5-yl)ethanone, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Merck & Co., Inc.; US4746669; (1988); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem