Category: 2080-75-3

2080-75-3, name is 5-Methoxy-1H-benzo[d]imidazol-2(3H)-one, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 2080-75-3

Intermediate 38:[0169] A mixture of intermediate 37 (3.6 g, 22 mmol) and 48% hydrogen iodide (30 mL) was heated to reflux (130C) and stirred for 12 h. The reaction mixture was neutralized to pH = 8 with aq NaOH and then extracted with EtOAc. The combined organic layers were dried over anhydrous Na2S04, concentrated under vacuum and purified by flash chromatography on silica gel column (elution with DCM/MeOH = 80: 1) to give 5-hydroxy-lH-benzo[cf]imidazol-2(3H)- one (intermediate 38) (16.9 g, 80%). HPLC: 99%, RT 1.377 min. MS (ESI) m/z 151.0 [M + H]+. mp: 186-187C

The synthetic route of 2080-75-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; JIN, Jian; ROTH, Bryan; FRYE, Stephen; WO2012/3418; (2012); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2080-75-3, name is 5-Methoxy-1H-benzo[d]imidazol-2(3H)-one, A new synthetic method of this compound is introduced below., Recommanded Product: 2080-75-3

Obtained through a method the N- acetyl benzylamine piperazine (II) intermediate (19. 6mmol), an alcoholic solution of formaldehyde (16. 3mmol), 5_ methoxy-1,3-dihydro-benzimidazol-2 – one (16. 3mmol) into 30ml of absolute ethanol, at room temperature for 15h. The reaction was concentrated under reduced pressure to give a crude oil. The crude product was purified by silica gel column chromatography to obtain the free base of N- benzyl-2- {4 – [(5-methoxy-2-oxo-2,3-dihydro-benzo -111- [(1] imidazole – 1- yl) methyl] piperazin-1-yl} -acetamide (V-18), 4. 44g, 66.6% yield.

The synthetic route of 2080-75-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shanghai Pharmaceutical Industry Research Academy; China State Institute of Pharmaceutical Industry; Li, Jiangqi; Weng, Zhije; Cui, Ning; Jie, Peng; Ma, Xiao; (25 pag.)CN105418506; (2016); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2080-75-3, name is 5-Methoxy-1H-benzo[d]imidazol-2(3H)-one, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Methoxy-1H-benzo[d]imidazol-2(3H)-one

To 5-methoxy-1H-benzo[d]imidazol-2(3H)-one (164 mg, 1 mmol, Lancaster) in DCM (2 mL) was added 1 M solution of aluminium trichloride in nitrobenzene (1 mL, 1 mmol, Aldrich). The reaction mixture was stirred at room temperature for 4 days and evaporated in vacuo. The residue was filtered through Celite, and the filter cake was washed with DCM. The DCM washings were discarded and the filter cake was washed with MeOH. The dark brown MeOH washings were collected and evaporated under reduced pressure. The residue was purified by silica gel column chromatography (gradient: 5-20% MeOH/CH2Cl2) to give the title compound as a pale-yellow solid. MS (ESI, pos. ion.) m/z: 151 (M+1).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Wang, Hui-Ling; Balan, Chenera; Doherty, Elizabeth M.; Falsey, James R.; Gore, Vijay Keshav; Katon, Jodie; Norman, Mark H.; US2005/176726; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 2080-75-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2080-75-3, name is 5-Methoxy-1H-benzo[d]imidazol-2(3H)-one belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

5.2 5-Methoxy-6-nitro-1H-benzo[d]imidazol-2(3H)-one (9) A solution of 17.5% fuming nitric acid (12.5 mL, 48.9 mmol) was slowly added to 5-methoxy-1H-benzo[d]imidazol-2(3H)-one (0.25 g, 1.5 mmol) at 0 C, and the reaction was stirred for 1 h at 0 C, and at 20 C for 3 h. The reaction mixture was cooled to 0 C and neutralised with saturated aqueous NaHCO3 solution. The product was extracted with EtOAc (2 * 50 mL), washed with water, dried, and concentrated to give 9 (113 mg, 36%) as a yellow solid: 1H NMR (400 MHz, DMSO-d6) delta = 11.21 (br s, 1H), 10.81 (br s, 1H), 7.47 (s, 1H), 6.80 (s, 1H), 3.89 (s, 3H); MS ES+ve m/z 210 (M+H)+, 251 (M+H+MeCN)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Methoxy-1H-benzo[d]imidazol-2(3H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Miah, Afjal H.; Abas, Hossay; Begg, Malcolm; Marsh, Benjamin J.; O’Flynn, Daniel E.; Ford, Alison J.; Percy, Jonathan M.; Procopiou, Panayiotis A.; Richards, Steve A.; Rumley, Sally-Anne; Bioorganic and Medicinal Chemistry; vol. 22; 15; (2014); p. 4298 – 4311;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem