Category: 206362-80-3

Application of 206362-80-3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 4-(Bromomethyl)-1-chloro-2-fluorobenzene, is researched, Molecular C7H5BrClF, CAS is 206362-80-3, about Synthesis of the diaryl ether cores common to chrysophaentins A, E, and F. Author is Brockway, Anthony J.; Grove, Charles I.; Mahoney, Maximillian E.; Shaw, Jared T..

The synthesis of the diaryl ether subunits (e.g. I) of the marine natural products chrysophaentin A, E, and F is described. These natural products feature tetrasubstituted benzene rings with complex substitution patterns. The central strategy involves an SNAr reaction between a complex phenol and a polysubstituted fluoronitrobenzene. Subsequent attempts to construct the unusual E-chloroalkene linkage through several different approaches are also disclosed.

There is still a lot of research devoted to this compound(SMILES：ClC1=C(C=C(CBr)C=C1)F)Application of 206362-80-3, and with the development of science, more effects of this compound(206362-80-3) can be discovered.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Recommanded Product: 206362-80-3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 4-(Bromomethyl)-1-chloro-2-fluorobenzene, is researched, Molecular C7H5BrClF, CAS is 206362-80-3, about The development of HEC-866 and its analogues for the treatment of idiopathic pulmonary fibrosis. Author is Lin, Runfeng; Zhang, Zheng; Cao, Shengtian; Yang, Wen; Zuo, Yinglin; Yang, Xinye; Zhang, Jiancun; Xu, Juan; Li, Jing; Wang, Xiaojun.

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with a typical survival time between three to five years. Two drugs, pirfenidone and nintedanib have been approved for the treatment of IPF, but they have limited efficacy. Thus, the development of new drugs to treat IPF is an urgent medical need. In this paper we report the discovery of a series of orally active pyrimidin-4(3H)-one analogs which exhibit potent activity in in vitro assays. Among them, HEC-866 showed promising efficacy in rat IPF models. Since HEC-866 also had good oral bioavailability, a long half-life and favorable long-term safety profiles, it was selected for further clin. evaluation.

There is still a lot of research devoted to this compound(SMILES：ClC1=C(C=C(CBr)C=C1)F)Recommanded Product: 206362-80-3, and with the development of science, more effects of this compound(206362-80-3) can be discovered.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 4-(Bromomethyl)-1-chloro-2-fluorobenzene, is researched, Molecular C7H5BrClF, CAS is 206362-80-3, about Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models, the main research direction is pyrazolo pyrimidine amine derivative preparation TRAP1 Hsp90 inhibitor cancer; Anticancer; Drug; Hsp90; Mitochondria; Selectivity; TRAP1.Name: 4-(Bromomethyl)-1-chloro-2-fluorobenzene.

TNF Receptor Associated Protein 1 (TRAP1) is a mitochondrial paralog of Hsp90 related to the promotion of tumorigenesis in various cancers via maintaining mitochondrial integrity, reducing the production of reactive oxygen species, and reprogramming cellular metabolism Consequently, Hsp90 and TRAP1 have been targeted to develop cancer therapeutics. Herein, we report a series of pyrazolo[3,4-d]pyrimidine derivatives that are mitochondria-permeable TRAP1 inhibitors. Structure-based drug design guided the optimization of potency, leading to the identification of compounds 47 and 48 as potent TRAP1 and Hsp90 inhibitors with good metabolic and plasma stability as well as acceptable CYP and hERG inhibition. X-ray co-crystallization studies confirmed both 47 and 48 interact with the ATP binding pocket in the TRAP1 protein. Compounds 47 and 48 demonstrated excellent anticancer efficiency in various cancer cells, with limited toxicity over normal hepatocyte and prostate cells. Mouse PC3 xenograft studies showed 47 and 48 significantly reduced tumor growth.

If you want to learn more about this compound(4-(Bromomethyl)-1-chloro-2-fluorobenzene)Name: 4-(Bromomethyl)-1-chloro-2-fluorobenzene, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(206362-80-3).

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 4-(Bromomethyl)-1-chloro-2-fluorobenzene, is researched, Molecular C7H5BrClF, CAS is 206362-80-3, about Discovery of novel, potent, isosteviol-based antithrombotic agents.Quality Control of 4-(Bromomethyl)-1-chloro-2-fluorobenzene.

Thrombosis is a pathol. coagulation process and can lead to many serious thrombotic diseases. Here, we report a novel potent antithrombotic compound (6k) based on isosteviol with anticoagulant and antiplatelet activities. 6k selectively inhibited FXa (Ki = 0.015μM) against a panel of serine proteases and showed excellent anticoagulant activity (significant prolongation of ex vivo PT and aPTT over the vehicle, p < 0.01). 6k also significantly inhibited ADP-induced platelet aggregation in rats relative to the vehicle (p < 0.01). Furthermore, 6k exhibited potent ex vivo and in vivo antithrombotic activity in rats relative to the vehicle (p < 0.01 and p < 0.0001, resp.). Novel structure 6k, with potent antithrombotic activity, is expected to lead a promising approach for the development of antithrombotic agents. Here is a brief introduction to this compound(206362-80-3)Quality Control of 4-(Bromomethyl)-1-chloro-2-fluorobenzene, if you want to know about other compounds related to this compound(206362-80-3), you can read my other articles.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Addla, Dinesh; Jallapally, Anvesh; Kanwal, Abhinav; Sridhar, Balasubramanian; Banerjee, Sanjay K.; Kantevari, Srinivas published the article 《Design, synthesis and evaluation of novel 2-hydroxypyrrolobenzodiazepine-5,11-dione analogues as potent angiotensin converting enzyme (ACE) inhibitors》. Keywords: angiotensin converting enzyme ACE inhibitor preparation; crystal structure.They researched the compound: 4-(Bromomethyl)-1-chloro-2-fluorobenzene( cas:206362-80-3 ).Electric Literature of C7H5BrClF. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:206362-80-3) here.

A series of novel 10-substituted 2-hydroxypyrrolobenzodiazepine-5,11-diones I [R = Me, MeC(O), Ph, etc.] designed through structure based rational hybridization approach, synthesized by the cyclodehydration of isotonic anhydride with (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid followed by N-substitution, were evaluated as angiotensin converting enzyme (ACE) inhibitors. Among all the new compounds screened (2R,11aS)-10-((4-bromothiophen-2-yl)methyl)-2-hydroxy-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-5,11(10H,11aH)dione, I [R = 3,4,5-(MeO)3C6H2] (IC50: 0.272 μM) emerged as most active noncarboxylic acid ACE inhibitor with minimal toxicity comparable to clin. drugs Lisinopril, Benazepril and Ramipril. Favorable binding characteristics in docking studies also supported the exptl. results.

If you want to learn more about this compound(4-(Bromomethyl)-1-chloro-2-fluorobenzene)Electric Literature of C7H5BrClF, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(206362-80-3).

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem