Category: 20485-43-2

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20485-43-2, name is 1-Methyl-1H-imidazole-2-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1-Methyl-1H-imidazole-2-carboxylic acid

A solution of Intermediate II (30 mg, 0.092 mmol) and 1-methyl-1H-imidazole- 2-carboxylic acid (14 mg, 0.11 mmol) in 1 mE of DMF was treated at 0 C with i-Pr2NEt (0.10 mL, 0.57 mmol) and propane phosphonic acid anhydride (T3P; 0.11 mL, 0.25 mmol). The vialwas sealed and stirred at room temperature ovemight. The reaction mixture was filtered, washing the filter with DMSO (1 niL). The crude product dissolved in 2 mL of DMSO/DMF was purified by reverse phase HPLC. The desired fraction was concentrated under reduced pressure to yield 2-39. ?Ii NMR (600 MHz, DMSO-d6) 3 8.48 (m, 1 H), 7.96 (m, 1 H), 7.28 (m, 1 H), 6.96 (m, 1 H), 5.88 (s, 1 H), 4.14 (q, J= 7.2 Hz, 2 H), 3.82 (s, 3 H), 3.80 (s, 3 H), 4.00-3.60(m, 4 H), 2.53-2.52 (m, 3 H), 2.35-2.20 (m, 2 H), 1.32 (t, J= 7.3 Hz, 3 H); MS (El) Calc?d for C21H26N902 [M+Hfb, 436; found 436.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 20485-43-2.

Reference:
Patent; MERCK SHARP & DOHME CORP.; ACHAB, Abdelghani Abe; ALTMAN, Michael D.; DENG, Yongqi; GUZI, Timothy; KATTAR, Solomon; KATZ, Jason D.; METHOT, Joey L.; ZHOU, Hua; MCGOWAN, Meredeth; CHRISTOPHER, Matthew P.; GARCIA, Yudith; ANTHONY, Neville John; FRADERA LLINAS, Francesc Xavier; MU, Changwei; ZHANG, Sixing; ZHANG, Rong; FONG, Kin Chiu; LENG, Xiansheng; WO2014/75392; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 20485-43-2,Some common heterocyclic compound, 20485-43-2, name is 1-Methyl-1H-imidazole-2-carboxylic acid, molecular formula is C5H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 135 (S,Z)-N-(1-(2-chloro-6-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)pyrrolidin-3-yl)-1-methyl-1H-imidazole-2-carboxamideTo a 50 mL vial charged with a magnetic stir bar was added (S,Z)-5-(2-(3-aminopyrrolidin-1-yl)-3-chlorobenzylidene)thiazolidine-2,4-dione (75 mg, 0.23 mmol) (Example 86), 1-methyl-1H-imidazole-2-carboxylic acid (87 mg, 0.69 mmol), HATU (220 mg, 0.58 mmol) and dichloromethane (5 mL). Hunig’s base (0.202 mL, 1.16 mmol) was then added and the mixture was stirred at rt for 4 h. The reaction was then diluted with dichloromethane and washed with water. The mixture was separated with a phase separator tube and the organic phase was evaporated to dryness. The residue was purified by reverse phase chromatography to afford the title compound as a yellow solid (21 mg, 21%). 1H NMR (400 MHz, DMSO-d6) delta ppm 7.89 (s, 1H) 7.51 (dd, 1H) 7.41 (dd, 1H) 7.18-7.27 (m, 2H) 7.01 (s, 1H) 4.67-4.77 (m, 1H) 4.00 (s, 3H) 3.63-3.75 (m, 2H) 3.47-3.54 (m, 1H) 3.36-3.47 (m, 1H) 2.39-2.51 (m, 1H) 2.14 (dd, 1H); m/z 432.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-imidazole-2-carboxylic acid, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; US2011/218182; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 20485-43-2,Some common heterocyclic compound, 20485-43-2, name is 1-Methyl-1H-imidazole-2-carboxylic acid, molecular formula is C5H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A) resin swelling: 400 mg of Fmoc-protected phenylhydrazine resin (0.66 mmol / g, 0.264 mmol) and 3 mL of CH2CI2 were added to a 10 mL solid phase reactor, the resin was swollen for 30 min, CH2CI2 was withdrawn, (B) removal of Fmoc protecting group: A solution of 3 mL of 20% piperidine / DMF was added to the swollen resin in step (a) N2 was bubbled and mixed. After lOmin, the solvent was extracted, and then 3 mL of 20% piperidine / DMF solution was added. N2 was bubbled and mixed. After lOmin, the resin was washed with DMF (4X3mL) and the resin was washed with 3 mL of anhydrous DMF ,spare; (C) Amino acid condensation: 4-tert-Butoxycarbonylamino-1-methyl-1H-pyrrole-2-carboxylic acid (254 mg, 1.056 mmol) and triphosgene (BTC, 128 mg, 0.433 mmol) were dissolved in 2 mL of anhydrous THF, A large amount of white precipitate was immediately added to the reaction, and the reaction was further carried out for 3 min. Then, 2 mL of a solution of DIEA / DMF (5%, nu / nu) The reaction solution was transferred to the phenylhydrazine resin in which the protecting group was removed, N2 was bubbled and mixed, the reaction was carried out for 0.5 to 1 h, the reaction solution was extracted, and the resin was washed with DMF (4 X 3 mL) ,spare;(D) removal of tert-butoxycarbonyl protecting group: The mixture was washed with CH2C12 (2 X 3 mL), the CH2C12 was removed, and the tert-butyl group was removed by the addition of 3. OmL TFA / benzoic acid / Eta2Omicron (nu: nu: nu = 92: 5: 2.5) (2 × 3 3) and DMF (4 X) were added to the reaction mixture for 2 min, and then the solvent was extracted for 2 min, and then the mixture was stirred for 20 min with 3. OmL TFA / phenol / H20 (nu: nu: nu = 92: 5: 2.5) 3 mL) and the resin was washed with 3 mL of anhydrous DMF, The above-mentioned condensation and deprotection steps (c) and (d) were repeated until completion of the synthesis of the peptide on the phenylhydrazine resin represented by the formula (1) (E) condensing amino acids: 4-tert-butoxycarbonylamino-1-methyl -1H- imidazole-2-carboxylic acid (254mg, 1.056mmol) and triphosgene (BTC, 128mg, 0.433mmol) was dissolved in 2mL anhydrous of THF, to this solution was slowly added dropwise trimethyl pyridine (collidine, 488muL, 3.696mmol), the reaction to produce a heavy white precipitate immediately addition was complete the reaction 3min, added 2mLDIEA / DMF solution (5%, v / v), white the precipitate completely disappeared, the reaction solution was transferred to step (b) deprotection of the resin phenylhydrazine, N 2Bubbled mixing, the condensation reaction 0.5 ~ 1h, the reaction solution pumping, with DMF (4 × 3mL) resin was washed, to give formula (2) is supported on the peptide resin represented phenylhydrazine;A(G) solution of R-2-(9-fluorenylmethoxycarbonylamino)-4-tert-butoxycarbonylaminobutyric acid (465 mg, 1.056 mmol) and triphosgene (128 mg, 0.433 mmol) in 2 mL of anhydrous THF was added to the solution (48 mg) was added dropwise to a solution of HOAt (144 mg, 1.056 mmol) followed by addition of 2 mL of DIEA / DMF solution (5%, nu / nu), followed by the addition of trimethylpyrone (488 yL, 3.696 mmol) The reaction solution was transferred to a linear peptide (NH2-Im-Im-Py-Py-phenylhydrazine resin) supported on a phenylhydrazine resin represented by the formula (1), and the N2 pellet was completely removed. And the reaction was carried out with DMF (4 x 3mL) to obtain the peptide supported on the phenylhydrazine resin as shown in formula (3) (H)repeating the condensation and deprotection guard step (d) and (C), wherein the load until the completion of the synthetic peptides of formula (4) in the resin phenylhydrazine;(I)repeating the condensation and deprotection guard step (d) and (E), wherein the load until the completion of the synthetic peptides shown in formula (5) in the resin phenylhydrazine;(J)1-methyl -1H- imidazole-2-carboxylic acid (132mg, 1.056mmol) and PyBOP (550mg, 1.056mmol) was dissolved in dry 3mL of DMF, DIEA (350muL, 2.112mmol ), the reaction 5min, the reaction solution was transferred to a step (h) the load represented by the formula (4) in the resulting peptide resin phenylhydrazine, N2Mix bubbled condensation reaction 2h, the reaction solution pumping, with DMF (4 × 3mL) the resin was washed, and the procedure (b) The method of removing the load represented by the formula (5) phenylhydrazine peptide on the resin Fmoc protecting group, the peptide load of formula (6) in a phenylhydrazine of the resin;(K) Boc2O (243muL, 1.056mmol) was dissolved in dry 3mL of DMF, DIEA (350muL, 2.112mmol), transferring the reaction solution to remove the Fmoc formula (6) is supported on the peptide resin phenylhydrazine, N2Mix bubbled condensation reaction 20min. In addition to pumping load reaction solution with DMF (4 × 3mL) the resin was washed to give Boc protected compound of formula (7) phenylhydrazine peptide on the resin;

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-imidazole-2-carboxylic acid, its application will become more common.

Reference:
Patent; Shenzhen Advanced Technology Institute; Su Wu; Wang Wei; Pan Zhengyin; Cheng Zhehong; Wu Chunlei; Fang Lijing; (36 pag.)CN106674209; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 20485-43-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 20485-43-2 as follows.

Example 16 rac-(3aR,14bR)-10-Cyclohexyl-N7-(dimethylsulfamoyl)-13-methoxy-N3a,N3a- dimethyl-2-((l-methyl-lH-imidazol-2-yl)carbonyl)-l,2,3,14b-tetrahydroindolo[2,l- a]pyrrolo[3,4-d][2]benzazepine-3a, 7(4H)-dicarboxamide. HATU (37.5 mg, 0.099 mmol) was added to a solution of rac-(3aR,14bR)-10-cyclohexyl-N7- (dimethylsulfamoyl)-13-methoxy-N3a,N3a-dimethyl-l,2,3,14b-tetrahydroindolo[2,l- alpha]pyrrolo[3,4-d][2]benzazepine-3a,7(4H)-dicarboxamide (30 mg, 0.049 mmol) and 1- methyl-lH-imidazole-2-carboxyIic acid (12.5 mg, 0.099 mmol) in DMF (1 mL) and TEA (0.03 mL, 0.2 mmol). The reaction mixture was stirred at rt for 16 h, diluted with MeOH, and purified by preparative HPLC (H2O/MeOH with 0.1% TFA buffer) to yield rac-(3aR,14bR)-10-cyclohexyl-N7-(dimethylsulfamoyl)-13-methoxy-N3a,N3a- dimethyl-2-(( 1 -methyl-1H-imidazol-2-yl)carbonyl)- 1 ,2,3 , 14b-tetrahydroindolo[2, 1 – alpha]pyrrolo[3,4-d][23benzazepine-3a,7(4H)-dicarboxamide (20.3 mg, 0.028 mmol, 57% yield) as a bright yellow solid. Complex mixture of rotamers was observed, partial 1H NMR (aromatic region) reported for 2 major rotamers (~3:2 ratio). 1H NMR (500 MHz, DMSO-d6) delta 6.78 (s, 0.6H), 6.91 (s, 0.4H), 7.00 (s, 0.4H), 7.05 (s, 0.4H), 7.08 – 7.22 (m, 2.2H), 7.32 (d, J= 8.2 Hz, 0.6H), 7.37 (d, J= 8.2 Hz, 0.4H), 7.54 (dd, J= 8.6, 1.2 Hz, 0.4H), 7.61 (dd, J= 8.6, 1.2 Hz, 0.6H), 7.81 (d, J= 8.6 Hz, 0.6H), 7.84 (d, J= 8.6 Hz, 0.4H), 8.09 (br s, 0.4H), 8.31 (br s, 0.6H), 11.31 (s, 0.4H), 11.69 (s, 0.6H). LCMS: m/e 716 (M+H)+, ret time 3.67 min, 4 minute gradient.

According to the analysis of related databases, 20485-43-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2009/120733; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 20485-43-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 20485-43-2 name is 1-Methyl-1H-imidazole-2-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: : 1 -methyl- lH-imidazole-2-carboxylic acid (67 mg, 0.53 mmol) was added to a solution of intermediate (G54) (0.200 g, 0.53 mmol), DIEA (0.40 mL, 2.3 mmol) and BOP (0.786 g, 1.7 mmol) in dry DMF (15 mL). The reaction mixture was stirred at RT for 6 hours. The mixture was poured into water and extracted with EtOAc. The organic layer was washed with water, dried over sodium sulfate, filtered and evaporated till dryness. The residue was purified by column chromatography then crystallized from Et20 to give (24%) compound (E22).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-imidazole-2-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; JANSSEN SCIENCES IRELAND UC; LANCOIS, David, Francis, Alain; GUILLEMONT, Jerome, Emile, Georges; RABOISSON, Pierre, Jean-Marie, Bernard; ROYMANS, Dirk, Andre, Emmy; ROGOVOY, Boris; BICHKO, Vadim; LARDEAU, Delphine, Yvonne, Raymonde; MICHAUT, Antoine, Benjamin; (326 pag.)WO2016/174079; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 20485-43-2, The chemical industry reduces the impact on the environment during synthesis 20485-43-2, name is 1-Methyl-1H-imidazole-2-carboxylic acid, I believe this compound will play a more active role in future production and life.

HATU (O-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate) (1.75g; 4.60 mmol) was added in on portion to a stirring solution of 1-methyl-1 H- imidazole-2-carboxylic acid (509 mg; 4.04 mmol), lambda/,O-dimethylhydroxylamine hydrochloride (391 mg; 4.01 mmol), and diisopropylethylamine (2.0 ml 1 1.9 mmol) in anhydrous DMF (14 ml_). The mixture was stirred at room temperature for 17 hours and partitioned between ethyl acetate (100 ml.) and water (100 ml_). The organic phase was dried (MgSO4) and concentrated in vacuo, giving a colourless oil (1.45 g). This was purified by column chromatography, giving the title compound as a colourless oil (494 mg; 73%). 1H-NMR (400MHz, CDCI3): 3.57 (3H, br s), 3.86 (3H, s), 3.91 (3H, s), 6.97 (1 H, d, J=I Hz), 7.07 (1 H, d, J=I Hz).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-imidazole-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXO GROUP LIMITED; WO2007/107539; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

20485-43-2, name is 1-Methyl-1H-imidazole-2-carboxylic acid, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 1-Methyl-1H-imidazole-2-carboxylic acid

A mixture of 5-methyl-2- (2-pyridyl)-5 ,6,7 ,8-tetrahydropyrido [4,3 d]pyrimidine trifluoroacetic acid salt (100 mg, 442 imol, the product of step 2 in Example 34), 1- methylimidazole-2-carboxylic acid (83.6 mg, 663 j.imol), HATU (336 mg, 884 imol) and DIPEA (171 mg, 1.33 mmol) in DMF (5 mL) was stuffed overnight at rt. The resulting mixturewas poured into water and extracted with DCM (30 mL) twice. The combined organic layer was concentrated in vacuo and the residue was purified by prep-HPLC to give (1-methylimidazol-2- yl)- [5-methyl-2- (2-pyridyl)-7 ,8 -dihydro-5H-pyrido [4,3-d]pyrimidin-6-yl] methanone (69 mg) as a light yellow solid. ?H NMR (400 MHz, Methanol-d4) oe: 8.5 1-8.80 (m, 2H), 8.33-8.43 (m, 1H), 7.80-7.92 (m, 1H), 7.34-7.47 (m, 1H), 7.07-7.18 (m, 1H), 6.97 (d, 1H), 5.66-5.86 (m, 1H), 4.66-4.75 (m, 0.4H), 4.49-4.60 (m, 0.6H), 3.74 (s, 3H), 3.48-3.63 (m, 0.7H), 3.23-3.41 (m, 1H), 2.88-3.15 (m, 1.3H), 1.56 (brd, 3H). MS obsd. (ESI)[(M+H)]: 335.

The synthetic route of 20485-43-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHENG, Zhanling; WANG, Jianhua; WANG, Min; YANG, Song; (84 pag.)WO2018/83106; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 20485-43-2, name is 1-Methyl-1H-imidazole-2-carboxylic acid, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20485-43-2, Safety of 1-Methyl-1H-imidazole-2-carboxylic acid

To a solution of i-methyl-I H-imidazole-2-carboxylic acid (500 mg, 3.57 mmol, commercially available from e.g. Sigma-AIdrich), Lambda/-[3-(dimethylamino)propyl]-N’- ethylcarbodiimide (554 mg, 3.57 mmol) and 1-H-1 ,2,3-benzotriazol-1-ol (54.6 mg, 0.357 mmol) in dichloromethane (20 ml) pre-stirred for 30 mins under argon at room temp was added solid t-butyl carbazate (722 mg, 5.35 mmol). The reaction mixture was stirred at RT for 18 h. The reaction mixture was partitioned between dichloromethane (~ 50 ml) and saturated sodium bicarbonate solution (~ 50 ml). The aqueous phase was extracted with dichloromethane (2 x 25 ml) and the combined organic extracts washed with saturated sodium bicarbonate solution (~ 25 ml), dried over magnesium sulphate and evaporated in vacuo to give the crude product as a yellow oil. This was purified via Biotage (1 :1 Hex/EtOAc; 40+M Biotage column) to afford the required product as a white solid in 143.8 mg.LCMS: 2 minute run in MeOH. [M-Boc+H]+ = 140.93; RT = 0.57-0.59 min

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-imidazole-2-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; GLAXO GROUP LIMITED; DEAN, David Kenneth; MUNOZ-MURIEDAS, Jorge; SIME, Mairi; STEADMAN, Jon Graham Anthony; THEWLIS, Rachel Elizabeth Anne; TRANI, Giancarlo; WALTER, Daryl Simon; WO2010/125102; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 20485-43-2, name is 1-Methyl-1H-imidazole-2-carboxylic acid, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20485-43-2, Formula: C5H6N2O2

To a solution of N4-(3-aminopropyl)-7-(lH-pyrazol-5-yl)quinoline-2,4-diamine, 3 HC1 (30 mg, 0.077 mmol) and 1 -methyl- lH-imidazole-2-carboxy lie acid (19.32 mg, 0.153 mmol) and triethylamine (0.213 mL, 1.532 mmol) in DMF (1 mL) was added T3P (50% in DMF) (97 mg, 0.153 mmol). After stirring the reaction at room temperature overnight the reaction was concentrated under high vacuum. The reaction was diluted with 1 ml of a mixture of 1: 1 DMF: acetic acid and filtered through a syringe filter and purified via preparative LC/MS with the following conditions: Column: XBridge CI 8, 200 mm x 19 mm, 5-mupiiota particles; Mobile Phase A: 5:95 acetonitrile: water with 0.1% trifluoroacetic acid; Mobile Phase B: 95 :5 acetonitrile: water with 0.1% trifluoroacetic acid; Gradient: a 5-minute hold at 0% B, 0-33% B over 25 minutes, then a 5-minute hold at 100% B; Flow Rate: 20 mL/min; Column Temperature: 25 C. Fraction collection was triggered by MS signals. Fractions containing the desired product were combined and dried via centrifugal evaporation to give N-(3-((2-amino-7-(lH-pyrazol-5-yl)quinolin-4- yl)ainino)propyl)-l-methyl-lH-imidazole-2-carboxarnide as the bis-triflouroacetate salt (7.1 mg, 15 %). NMR (500 MHz, DMSO-de) delta 8.44 (br s, 1H), 8.22 (br d, J=8.7 Hz, 1H), 8.02 (br s, 1H), 7.93 (br s, 1H), 7.90 – 7.76 (m, 3H), 7.55 (br s, 1H), 7.30 (s, 1H), 6.99 (s, 1H), 6.87 – 6.80 (m, 1H), 5.85 (s, 1H), 3.94 (s, 3H), 2.01 – 1.93 (m, 2H). Four protons from sidechain missing, likely due to overlap with suppressed water peak. LC RT: 1.01 min. M/Z=391.1

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-imidazole-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; INNATE TUMOR IMMUNITY, INC.; O’MALLEY, Daniel; GAVAI, Ashvinikumar V.; GILL, Patrice; TARBY, Christine M.; WATTERSON, Scott Hunter; GONG, Hua; WILLIAMS, David K.; GHOSH, Shomir; ROUSH, William R.; (307 pag.)WO2019/14402; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20485-43-2, name is 1-Methyl-1H-imidazole-2-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C5H6N2O2

A solution of Intermediate II (30 mg, 0.092 mmol) and 1-methyl-1H-imidazole- 2-carboxylic acid (14 mg, 0.11 mmol) in 1 mE of DMF was treated at 0 C with i-Pr2NEt (0.10 mL, 0.57 mmol) and propane phosphonic acid anhydride (T3P; 0.11 mL, 0.25 mmol). The vialwas sealed and stirred at room temperature ovemight. The reaction mixture was filtered, washing the filter with DMSO (1 niL). The crude product dissolved in 2 mL of DMSO/DMF was purified by reverse phase HPLC. The desired fraction was concentrated under reduced pressure to yield 2-39. ?Ii NMR (600 MHz, DMSO-d6) 3 8.48 (m, 1 H), 7.96 (m, 1 H), 7.28 (m, 1 H), 6.96 (m, 1 H), 5.88 (s, 1 H), 4.14 (q, J= 7.2 Hz, 2 H), 3.82 (s, 3 H), 3.80 (s, 3 H), 4.00-3.60(m, 4 H), 2.53-2.52 (m, 3 H), 2.35-2.20 (m, 2 H), 1.32 (t, J= 7.3 Hz, 3 H); MS (El) Calc?d for C21H26N902 [M+Hfb, 436; found 436.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 20485-43-2.

Reference:
Patent; MERCK SHARP & DOHME CORP.; ACHAB, Abdelghani Abe; ALTMAN, Michael D.; DENG, Yongqi; GUZI, Timothy; KATTAR, Solomon; KATZ, Jason D.; METHOT, Joey L.; ZHOU, Hua; MCGOWAN, Meredeth; CHRISTOPHER, Matthew P.; GARCIA, Yudith; ANTHONY, Neville John; FRADERA LLINAS, Francesc Xavier; MU, Changwei; ZHANG, Sixing; ZHANG, Rong; FONG, Kin Chiu; LENG, Xiansheng; WO2014/75392; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem