20271-20-9 Archives - Imidazoles-derivatives

The important role of 20271-20-9

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 5-nitro-1H-imidazole-4-carboxylate, its application will become more common.

Electric Literature of 20271-20-9,Some common heterocyclic compound, 20271-20-9, name is Methyl 5-nitro-1H-imidazole-4-carboxylate, molecular formula is C5H5N3O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of Description 17 (1.24g, 7. 25 mmol) in1 : 1 ethanol : methanol (60 ml) was hydrogenated using 10 % palladium on carbon catalyst under a balloon of hydrogen. After 4 h the reaction mixture was filtered, the filtrate condensed and azeotroped with ethanol. The product was triturated with ethyl acetate and dried to give the title compound as a white solid (0.98 g, 96%).’H NMR (400 MHz, DMSO)8 12.0(1H, brs), 7.32(1H, s), 5.56 (2H, s), 3.70 (3H, s). Mlz (ES+) 142 (M+H+).

Reference:
Patent; MERCK SHARP & DOHME LIMITED; HOLLINGWORTH, Gregory, John; JONES, A., Brian; SPAREY, Timothy, Jason; WO2005/49613; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Discovery of 20271-20-9

The synthetic route of 20271-20-9 has been constantly updated, and we look forward to future research findings.

Reference of 20271-20-9, These common heterocyclic compound, 20271-20-9, name is Methyl 5-nitro-1H-imidazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

20.1 g (0.13 mol) of diethyl sulphate, 132 ml of an 8% strength aqueous sodium bicarbonate solution and 132 ml of water are added to a solution of 15.0 g (0.09 mol) of methyl 5-nitro-1H-imidazole-4-carboxylate in 420 ml of tetrahydrofuran. The reaction mixture is stirred at room temperature overnight and then extracted with 3*50 ml of ethyl acetate. The combined organic phases are dried over magnesium sulphate and freed of the solvent under reduced pressure. Purification by column chromatography on silica gel using pentane/ethyl acetate (40:1) gives 3.50 g (20% of theory) of the title compound and 12.0 g (69% of theory) of the isomeric methyl 1-ethyl-4-nitro-M-imidazole-5-carboxylate. Title compound 1H-NMR (MeOD-D4, 400 MHz) delta ppm: 7.99 (s, 1H), 4.36 (q, 2H), 3.91 (s, 3H), 1.48 (t, 3H) Methyl 1-ethyl-4-nitro-1H-imidazole-5-carboxylate 1H-NMR (CDCl3, 400 MHz) delta ppm: 7.45 (s, 1H), 4.26 (s, 3H), 3.96 (s, 3H), 1.49 (t, 3H)

The synthetic route of 20271-20-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER CROPSCIENCE AG; ALIG, Bernd; CEREZO-GALVEZ, Silvia; FISCHER, Reiner; KOEHLER, Adeline; HAHN, Julia Johanna; BECKER, Angela; ILG, Kerstin; VOERSTE, Arnd; GOERGENS, Ulrich; PORTZ, Daniela; US2015/344499; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A new synthetic route of Methyl 5-nitro-1H-imidazole-4-carboxylate

The synthetic route of Methyl 5-nitro-1H-imidazole-4-carboxylate has been constantly updated, and we look forward to future research findings.

Reference of 20271-20-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20271-20-9, name is Methyl 5-nitro-1H-imidazole-4-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

The synthetic route of Methyl 5-nitro-1H-imidazole-4-carboxylate has been constantly updated, and we look forward to future research findings.