Category: 20034-02-0

Some common heterocyclic compound, 20034-02-0, name is (6-Methyl-1H-benzo[d]imidazol-2-yl)methanol, molecular formula is C9H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of (6-Methyl-1H-benzo[d]imidazol-2-yl)methanol

N-Methyl-2-methanol-5-methylbenzimidazole 48 was prepared according to using the procedure by Harisha et al. [28]. A solution of 5-methyl-(1H-benzimidazole-2-yl)-methanol 25 (1.62 g, 0.01 mol), and sodium hydroxide (0.40 g, 0.01 mol) were stirred in dry acetone (30 mL) was stirred for 30 min. Then, iodomethane (1.41 g, 0.01 mol) was added to the mixture and the mixture was stirred for 24 h. The reaction mixture was concentrated to a quarter and then poured into ice-cold water. The solid was filtered and washed with 50% HCl to neutralize the excess potassium carbonate. Then, wash the solid with cold water (100 mL) and then aqueous ethanol. The product was purified by column chromatography (9:1 chloroform/ethanol) to give the desired product (FAS37) as a brown powder Yield 46%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 20034-02-0, its application will become more common.

Reference:
Article; Alasmary, Fatmah A.S.; Snelling, Anna M.; Zain, Mohammed E.; Alafeefy, Ahmed M.; Awaad, Amani S.; Karodia, Nazira; Molecules; vol. 20; 8; (2015); p. 15206 – 15223;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

These common heterocyclic compound, 20034-02-0, name is (6-Methyl-1H-benzo[d]imidazol-2-yl)methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C9H10N2O

General procedure: One of compounds 4a-4f (5 mmol) was dissolved in THF (25 mL) and DCC (1.24 g, 6 mmol), and DMAP (0.12 g, 1 mmol) was slowly added and the mixture was stirred for 30 min. Compounds 2a-2c (5 mmol) was added and the mixture was stirred for 7-9 h. The by-product, N,N’-dicyclohexylurea, was removed by filtration. The filtrate was concentrated in vacuum to give a solid which was dissolved in CH2Cl2 and the product 5a-5n was filtered off.

The synthetic route of (6-Methyl-1H-benzo[d]imidazol-2-yl)methanol has been constantly updated, and we look forward to future research findings.

Reference:
Letter; Zhang; Xu; Wang; Kang; Russian Journal of General Chemistry; vol. 87; 12; (2017); p. 3006 – 3016;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem