Category: 20033-99-2

Application of 20033-99-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20033-99-2, name is 2-(Hydroxymethyl)-5-methoxybenzimidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Example 34: Synthesis of 2-chloromethyl-5-methoxy-lH-benzoimidazole 222[0265] 2-Chloromethyl-5-methoxy-l H-benzoimidazole 222 was synthesized in 1 step from (5- Methoxy-lH-benzoimidazol-2-yl)-methanol 221 as shown in Scheme 58.Scheme 58Step 1 – Preparation of2-chloromethyl-5-methoxy-lH-benzoimidazole (222): [0266] (5-Methoxy-lH-benzoimidazol-2-yl)-methanol (221, 0.5 g, 3 mmol) was combined with 30 mL dichloromethane. Thionyl chloride (0.51 mL, 7 mmol) was added and the reaction was stirred at room temperature for 2 hours. The reaction was concentrated. Ethyl acetate was added and washed with sodium bicarbonate saturated solution and brine. The organic portion was dried over anhydrous sodium sulfate, filtered through Celite and evaporated to dryness. The resulting desired compound was used without further purification. MS (ESI) : [M+lT] + == 197.2.

The synthetic route of 2-(Hydroxymethyl)-5-methoxybenzimidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PLEXXIKON, INC.; WO2008/80001; (2008); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20033-99-2, name is 2-(Hydroxymethyl)-5-methoxybenzimidazole, A new synthetic method of this compound is introduced below., Quality Control of 2-(Hydroxymethyl)-5-methoxybenzimidazole

A suspension of (5-Methoxy-1H-benzimidazol-2-yl)methanol (preparation 1) (638 mg, 3.58 mmol) in 1N aqueous sodium hydroxide (0.95 ml) and water (40 ml) was heated to reflux and a solution of potassium permanganate (848 mg, 5.36 mmol) in water was added drop wise over a period of 30 minutes. The reaction mixture was refluxed for a further hour and then cooled to room temperature. The reaction mixture was acidified to pH4 by addition of acetic acid and the resulting solid filtered and dried in vacuo to give the title compound as a pale yellow solid (332 mg).

The synthetic route of 20033-99-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Lane, Charlotte Alice Louise; Price, David Anthony; US2006/111416; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 20033-99-2, A common heterocyclic compound, 20033-99-2, name is 2-(Hydroxymethyl)-5-methoxybenzimidazole, molecular formula is C9H10N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Thionyl chloride (27.5 mmol, 2 mL) was added slowly to a solution of 5-methoxy-1H-benzimidazole-2-yl)-methanol) 26 (0.58 g, 3.31 mmol) in dichloromethane (10 mL) at 10 C, the mixture was stirred until no presence of the starting material. The solvent was then evaporated, and the residue was triturated with DCM, and suction filtered, then was washed with dichloromethane and ether. Yield 89% which 34 was recovered as a green powder.

The synthetic route of 20033-99-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Alasmary, Fatmah A.S.; Snelling, Anna M.; Zain, Mohammed E.; Alafeefy, Ahmed M.; Awaad, Amani S.; Karodia, Nazira; Molecules; vol. 20; 8; (2015); p. 15206 – 15223;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem