Category: 195053-92-0

Application of 195053-92-0, The chemical industry reduces the impact on the environment during synthesis 195053-92-0, name is 2-(1-Trityl-1H-imidazol-4-yl)ethanamine, I believe this compound will play a more active role in future production and life.

A mixture of Meldrum’s acid (5.52 g, 38.3 mmol), potassium carbonate (26.5 g, 191 mmol) and methyl iodide (7.15 mL, 115 mmol) in acetonitrile (75 mL) was heated at 75 C in a sealed tube for 7 hrs. The mixture was cooled to room temperature, diluted with dichloromethane (300 mL), filtered and the filtrate evaporated to dryness in vacuo. Ethyl acetate (75 mL), hexanes (75 mL) and water (50 mL) were added and phases were separated. The organic layer was washed with 10% aqueous solution of sodium thiosulfate (50 mL) and water (50 mL); dried over anhydrous magnesium sulfate and solvent removed in vacuo to give 2,2,5,5-tetramethyl-[1,3]dioxane-4,6-dione as white solid. Yield: 6.59 g (79%). RF (SiO2, chloroform/ethyl acetate, 98:2): 0.60. 1H NMR spectrum (300 MHz, CDCl3, deltaH): 1.76 (s, 6 H); 1.65 (s, 6 H). A solution of 2-(1-Trityl-1H-imidazol-4-yl)-ethyl amine (5.00 g, 14.2 mmol) prepared as described above and triethylamine (9.86 mL, 70.7 mmol) in toluene (80 mL) was added dropwise over 50 min to a solution of the above dione compound (3.65 g, 21.2 mmol) in toluene (40 mL) at 75 C. The mixture was stirred at this temperature for additional 3 hrs (until the starting amine was detected on TLC), then it was evaporated to dryness. The residue was redissolved in chloroform (300 mL) and washed with 10% aqueous solution of citric acid (200 mL). The aqueous phase was extracted with chloroform (2 x 60 mL); the chloroform phases were combined, dried over anhydrous magnesium sulfate and solvent removed in vacuo. The residue was triturated with hot chloroform (140 mL); hexanes (70 mL) were added and the suspension was stirred at room temperature overnight. Solids were filtered off, washed with chloroform/hexanes mixture (1:1, 2 x 50 mL) and dried in vacuo to give the title product. Yield: 6.73 g (88%). M.p.: 161-162 C. RF (SiO2, chloroform/methanol, 85:15): 0.40. 1H NMR spectrum (300 MHz, DMSO-d6, deltaH): 12.45 (bs, 1 H); 7.66 (t, J=5.1 Hz, 1 H); 7.57-7.31 (m, 9 H); 7.26 (s, 1 H); 7.20-7.02 (m, 6 H); 6.66 (s, 1 H); 3.25 (m, 2 H); 2.57 (t, J=7.3 Hz, 2 H); 1.21 (s, 6 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(1-Trityl-1H-imidazol-4-yl)ethanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Novo Nordisk A/S; SAUERBERG, Per; LAU, Jesper; LINDEROTH, Lars; KODRA, Janos Tibor; SPETZLER, Jane; GARIBAY, Patrick William; (119 pag.)EP3000482; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 195053-92-0,Some common heterocyclic compound, 195053-92-0, name is 2-(1-Trityl-1H-imidazol-4-yl)ethanamine, molecular formula is C24H23N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 35 N-[2-(4(5)-Imidazoyl)ethyl]-N’-phenylmethyl-sulfamide 4-(2-Aminoethyl)-1-(triphenylmethyl)-imidazole (Example 17 step b) was converted to N-2-[1-(triphenylmethyl)imidazol-4-yl]ethyl-N’-tert-butoxycarbonyl-sulfamide according to the procedure of Example 12 step a.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(1-Trityl-1H-imidazol-4-yl)ethanamine, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 195053-92-0, name is 2-(1-Trityl-1H-imidazol-4-yl)ethanamine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 195053-92-0

To synthesize Limz1 2-(1-trityl-1H-imidazol-4-yl-)ethyl amine (1.00 g, 2.83 mmol), trimethylacetaldehyde(0.62 mL, 5.66 mmol, 2 eq.) and sodium sulfate (10.1 g,70.7 mmol, 25 eq.) were dissolved in dry toluene (15 mL).The mixture was stirred at room temperature for at least3 h. The residue was filtered off and washed twice withdry toluene (2 ¡Á 3 mL). The solvent was removed untila colorless solid precipitated. After 24 h the solid was filtered,washed with acetonitrile and dried in vacuum toafford Limz1 (728 mg, 1.23 mmol, 61 %) as a white powder.Anal. calcd. for C29H31N3: C (82.62 %); H (7.41 %); N(9.97 %); found C (82.56 %); H (7.50 %); N (9.90 %). 1HNMR(CDCl3, 400 MHz): delta = 7.46 (t, J = 1.2 Hz, 1H, imidazoleH-2), 7.37-7.27 (m, 9H, Ar-H), 1.15-7.10 (m, 6H,Ar-H), 6.56 (s, 1H, imidazole H-5), 3.64 (t, J = 7.0 Hz,2H, -CH2-CH2-N-), 2.82 (t, J = 7.0 Hz, 2H, -CH2-CH2-N-), 0.97 (s, 9H, -C(CH3)3) ppm. 13C-NMR (CDCl3,100 MHz): delta = 172.5 (CH, 1C, -N=CH-C(CH3)3), 142.8(C, 3C, phenyl C-1), 139.5 (C, 1C, imidazole C-4), 138.4 (CH, 1C, imidazole C-2), 129.9 (CH, 6C, phenyl C-3, C-5),128.1 (CH, 6C, phenyl C-2, C-6), 128.0 (CH, 3C, phenylC-4), 118.7 (CH, 1C, imidazole C-5), 75.2 (C, 1C, -N-C-(C6H6)3), 60.6 (CH2, 1C, -CH2-CH2-N=), 36.0 (C, 1C,=CH-C(CH3)3), 30.2 (CH2, 1C, -CH2-CH2-N=), 27.1 (C,3C, =CH-C(CH3)3) ppm.

According to the analysis of related databases, 195053-92-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Wendt, Franziska; Naether, Christian; Tuczek, Felix; Journal of Biological Inorganic Chemistry; vol. 21; 5-6; (2016); p. 777 – 792;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem