Category: 19485-38-2

Adding a certain compound to certain chemical reactions, such as: 19485-38-2, name is 1-Methylimidazole-4,5-dicarboxylic Acid, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19485-38-2, category: imidazoles-derivatives

In a 100 mL round bottom flask was added 1 mmol4,5-dicarboxy-1-methyl-1H-imidazole,1 mmol HOBT, dissolved in 20 mL ethyl acetate and stirred at 0 C for 30 min. Join 1mmol DCC, 0 reaction 2.5h, magnetic stirring.Dropping 1mmol dehydroabiety amine ethyl acetate solution 5mL,Reaction overnight. TLC followed the reaction until the reaction was complete. Then ice bath for half an hour, making DCU precipitation. DCU was removed by filtration and the filtrate was diluted to 200 mL and washed with 5% NaHCO3 (10 mL * 3), 10% citric acid (10 mL * 3) 2-3 times and saturated brine (10 mL * 3). The ethyl acetate layer was dried over anhydrous sodium sulfate. Filtration, the filtrate point plate, two points, the two points separated by the column to give compound L1 and compound L2, respectively, characterized.The L1 yield was 34.7% and the L2 yield was 35.1%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methylimidazole-4,5-dicarboxylic Acid, and friends who are interested can also refer to it.

Reference:
Patent; Nanjing Forestry University; Xu Li; Zhao Fengyi; Lu Wen; Xu Yuanyuan; Wang Luna; Xue Huayu; Cao Fuliang; (9 pag.)CN106220570; (2016); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

19485-38-2, name is 1-Methylimidazole-4,5-dicarboxylic Acid, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 19485-38-2

Example 238 HATU (83 mg, 0.22 mmol) was added to a mixutre of l-methyl-lH-imidazole-4,5- dicarboxylic acid (17.8 mg, 0.10 mmol) and an HCl salt of Intermediate 32 (80 mg, 0.21 mmol) in DMF (1 mL) and DIPEA (0.091 mL, 0.52 mmol) and the reaction mixture was stirred at rt for 16 h. The reaction was filtered and purified by preparative HPLC to afford the title compound (10.5 mg). LC-MS retention time = 2.85 min; m/z = 827.2 [M+H]+. (Column: Waters Acquity UPLC BEH C18, 2.1 x 50 mm, 1.7-muiotaeta particles; Mobile Phase A: 5:95 acetonitrile:water with 10 mM ammonium acetate; Mobile Phase B: 95:5 acetonitrile: water with 10 mM ammonium acetate; Temperature: 50 C; Gradient: 0- 100% B over 3 minutes, then a 0.75-minute hold at 100% B; Flow: 1.0 mL/min;

The synthetic route of 19485-38-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; VIIV HEALTHCARE (No.5) LIMITED; BENDER, John A.; LOPEZ, Omar D.; NGUYEN, Van N.; YANG, Zhong; WANG, Alan Xiangdong; WANG, Gan; MEANWELL, Nicholas A.; BENO, Brett R.; FRIDELL, Robert A.; BELEMA, Makonen; THANGATHIRUPATHY, Srinivasan; (350 pag.)WO2016/172425; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem