Category: 18874-52-7

Albright, J. Donald published the artcileSynthesis of 4-aroyl-5-nitro-1H-imidazoles and 4-aroyl-5-aminoimidazoles, Related Products of imidazoles-derivatives, the main research area is nitroimidazole; aroylaminoimidazole; aminoimidazole aroyl; imidazole aroyl amino nitro.

The reaction of α-(aryl)-4-morpholineacetonitriles (masked aroyl anion equivalent) with N-protected 4(5)-bromo-5(4)-nitro-1H-imidazoles gave 4-aroyl-5-nitroimidazoles, which were reduced to afford 4-aroyl-5-aminoimidazoles. Thus, imidazole I (R = Bz) was prepared from I (R = Br) and nitrile II.

Journal of Heterocyclic Chemistry published new progress about nitroimidazole; aroylaminoimidazole; aminoimidazole aroyl; imidazole aroyl amino nitro. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Related Products of imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kochergin, P. M. published the artcileInvestigations in the imidazole series 97. Synthesis and some transformations of 5-nitro-5-hydroxyalkylamino- and 4-hydroxyalkylamino-5-nitroimidazoles, Application In Synthesis of 18874-52-7, the main research area is nitrohydroxyalkylaminoimidazole preparation reaction; imidazole nitro hydroxyalkylamino preparation reaction; hydroxyalkylaminoimidazole nitro preparation reaction.

A series of 1-alkyl(1,2-dialkyl)-substituted 4-nitro-5-hydroxyalkylamino- and 4-hydroxyalkylamino-5-nitroimidazoles were obtained by the reaction of 1-alkyl(1,2-dialkyl)-substituted 4-nitro-5-chloro(bromo)imidazoles with amino alcs. Their reactions with thionyl chloride and carboxylic acid halides and their catalytic hydrogenation were studied.

Chemistry of Heterocyclic Compounds (New York)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) published new progress about nitrohydroxyalkylaminoimidazole preparation reaction; imidazole nitro hydroxyalkylamino preparation reaction; hydroxyalkylaminoimidazole nitro preparation reaction. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Application In Synthesis of 18874-52-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kochergin, P. M. published the artcileSynthesis of 7-methyl-6-(nitroimidazolyl)thiopurines, Recommanded Product: 5-Bromo-2-methyl-4-nitroimidazole, the main research area is methylnitroimidazolylthiopurine preparation; purine methylnitroimidazolylthio preparation; imidazolylthiopurine methylnitro preparation.

We have studied the reactions of 7-methyl-6-thiopurine with 5(4)-halo-4(5)-nitroimidazoles and 6-chloro-7-methylpurine with sodium and ammonium salts of 5-mercapto-4-nitroimidazoles. We have obtained a series of 7-methyl-6-(nitroimidazolyl)thiopurines not previously described in the literature.

Chemistry of Heterocyclic Compounds (New York)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) published new progress about methylnitroimidazolylthiopurine preparation; purine methylnitroimidazolylthio preparation; imidazolylthiopurine methylnitro preparation. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Recommanded Product: 5-Bromo-2-methyl-4-nitroimidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Meshcheryakova, S. A. published the artcileSynthesis of new thietanylpyrimidine and thietanylimidazole derivatives, Synthetic Route of 18874-52-7, the main research area is pyrimidine chloromethylthiirane alkylation rearrangement; chloromethylthiirane imidazole alkylation rearrangement; thietane pyrimidine preparation; imidazole thietane preparation.

New thietanyl-substituted derivatives of pyrimidine-2,4(1H,3H)-dione and imidazole were synthesized. The alkylation of 6-methylpyrimidine-2,4(1H,3H)-diones with 2-(chloromethyl)thiirane in water involved N(1) of the pyrimidine ring and afforded 6-methyl-1-(thietan-3-yl)pyrimidine-2,4(1H,3H)-diones. Under analogous conditions, 6-aminopyrimidine-2,4(1H,3H)-dione gave 6-(thietan-3-ylamino)pyrimidine-2,4(1H,3H)-dione. Unsym. substituted 2-methyl-4(5)-nitro- and 5(4)-bromo-2-methyl-4(5)-nitro-1H-imidazoles reacted with 2-(chloromethyl)thiirane to produce mixtures of isomeric 2-methyl-4(5)-nitro-1-(thietan-3-yl)-1H-imidazoles and 5(4)-bromo-2-methyl-4(5)-nitro-1-(thietan-3-yl)-1H-imidazoles.

Russian Journal of Organic Chemistry published new progress about Alkylation. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Synthetic Route of 18874-52-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Sobiak, Stanislaw published the artcileTetrabutylammonium bromide as a catalyst for reaction of 5(4)-bromo-2-methyl-4(5)-nitroimidazole with phenacyl bromides, Category: imidazoles-derivatives, the main research area is tetrabutylammonium bromide catalyst alkylation bromomethylnitroimidazole; bromomethylnitroimidazole sonication alkylation phenacyl bromide; nitroimiazole bromo alkylation phenacyl bromide; imidazole bromomethylnitro alkylation phenacyl bromide.

Reactions of 5(4)-bromo-2-methyl-4(5)-nitroimidazole with phenacyl bromides BrCH2COC6H4X-4 (X = H, F, Cl, Br, iodo), tetrabutylammonium bromide and sodium bicarbonate under sonication conditions gave mixtures of 4-bromo-5-nitroimidazoles I and 5-bromo-4-nitroimidazoles II in excellent yields of over 85% and, surprisingly, with I/II isomer ratios of 2:1.

Acta Poloniae Pharmaceutica published new progress about Alkylation. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Category: imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rao, A. K. S. Bhujanga published the artcileA new high-yielding method for the preparation of 2-alkyl- and 1,2-dialkyl-4-nitro-5-bromoimidazoles, Synthetic Route of 18874-52-7, the main research area is alkylnitroimidazole bromination; bromoimidazole alkylnitro; alkylbromonitroimidazole; imidazole alkylnitro bromination.

A new brominating system Br2-DMF-KHCO3 is described for the preparation of the title compounds I (R = H, Et, CH2CH2CN, CH2CH2COMe, CH2CH2CO2Et, CH2CH2CO2H, CH2CO2Et, CH2Ph, CH2C6H4Cl-4, CH2CH2SO2Et, cyclopropylmethyl; R1 = Me, Et). The mild conditions of the reaction allow bromination to be carried out in the presence of acid and base sensitive functionalities in nearly quant. yields.

Journal of Organic Chemistry published new progress about Bromination. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Synthetic Route of 18874-52-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dumanovic, D. published the artcileSimultaneous determination of N-substituted and N-substituted nitroazoles, and criteria for their identification. III. Chromatographic separation and polarographic determination of halonitroimidazoles, Name: 5-Bromo-2-methyl-4-nitroimidazole, the main research area is halonitroimidazole mixture polarog chromatog; chromatog thin layer halonitroimidazole; nitroimidazole halo polarog determination; imidazole halo nitro determination.

Halonitroimidazoles with the NO2 group in the same position are separated for identification by thin-layer chromatog. on unactivated silica gel HF254 in an atm. saturated with the vapor of 1 of 5 developers, the plate then being sprayed with 15% SnCl2 solution in aqueous HCl, dried, sprayed with p-dimethylaminobenzaldehyde solution, and redried. All 4-nitro derivatives give a yellow color and 4(5)- and 5-nitro compounds are yellow-red. Polarog. determination of halonitroimidazoles may be used in all synthetic processes where the azoles were prepared by nitration of haloimidazoles. A sample of the reaction mixture containing ≤10-3M polarog.-active compound and a suitable buffer is polarographed in the presence and absence of 2 ml 10-3M standard solution of the imidazole being determined and the amount imidazole is directly calculated from the observed wave heights. For halonitroimidazoles obtained from 5(4)-halo-4(5)-nitroimidazoles by substitution of the imino H, and when only one N-substituted derivative is present in the reaction mixture, simultaneous polarog. determination of both compounds is possible only in alk. medium. For mixtures on which simultaneous polarog. determination is impossible a sample of the reaction mixture containing 3 × 10-3-10-2M of all polarog.-active compounds is chromatog. separated and the bands are removed, dissolved in water, and then polarographed.

Talanta published new progress about Chromatography. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Name: 5-Bromo-2-methyl-4-nitroimidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Tykarska, Ewa published the artcile2-(5-Bromo-2-methyl-4-nitroimidazol-1-yl)-1-(2-chlorophenyl)ethanone, HPLC of Formula: 18874-52-7, the main research area is mol structure bromomethylnitroimidazolyl chlorophenyl ethanone; crystal structure bromomethylnitroimidazolyl chlorophenyl ethanone.

In the title compound, C12H9BrClN3O3, the nitro group lies in the plane of the imidazole ring, whereas the benzene and acetyl groups are markedly twisted relative to the heterocyclic ring. A weak C-H…O interaction helps to establish the crystal packing. Crystal data: monoclinic, space group Cc, a 8.4929(8), b 23.8609(13), c 7.5005(5) Å, β 120.190(7)°, Z = 4, 2476 observed reflections with I > 2σ(I), 182 refined parameters, R[F2 > 2σ(F2)] = 0.022, wR(F2) = 0.054 at T = 220(2) K.

Acta Crystallographica, Section E: Structure Reports Online published new progress about Crystal structure. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, HPLC of Formula: 18874-52-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kulkarni, Surendra published the artcileNucleophilic displacements of imidazoles. I. Oxygen, nitrogen and carbon nucleophiles, Safety of 5-Bromo-2-methyl-4-nitroimidazole, the main research area is nitroimidazole halo nucleophile substitution regiochem; halonitroimidazole; iodonitroimidazole nucleophile substitution; bromonitroimidazole; methoxymethylnitroimidazole crystal mol structure.

Bromo- and iodonitroimidazoles I (R = Br, iodo; R1, R2 = H, Me) and II (same R, R1) undergo nucleophilic displacement with MeO-, PhO-, cyclic secondary amines, and cyanide. The regiochem. of the reaction of I (R = iodo; R1 = R2 = H) with MeO- was confirmed by x-ray crystallog. of the product I (R = MeO; R1 = R2 = H).

Australian Journal of Chemistry published new progress about Crystal structure. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Safety of 5-Bromo-2-methyl-4-nitroimidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wagner, Pawel published the artcileCrystal packing of two 5-substituted 2-methyl-4-nitro-1H-imidazoles, Safety of 5-Bromo-2-methyl-4-nitroimidazole, the main research area is crystal packing methyl nitro imidazole derivative; mol structure bromomethylnitroimidazole methylnitroimidazolecarbonitrile; structure crystal bromomethylnitroimidazole methylnitroimidazolecarbonitrile; hydrogen bond bromomethylnitroimidazole methylnitroimidazolecarbonitrile.

Infinite chains connected by N-H···N H bonding form the primary packing motif in two closely related 4-nitroimidazole derivatives, viz. 5-bromo-2-methyl-4-nitro-1H-imidazole, C4H4BrN3O2, (I), and 2-methyl-4-nitro-1H-imidazole-5-carbonitrile, C5H4N4O2, (II). These chains are almost identical, even though in (II) there are two symmetry-independent mols. in the asym. unit. The differences appear in the interactions between the chains; in (I), there are strong C-Br···O halogen bonds, which connect the chains into a two-dimensional grid, while in (II), the cyano group does not participate in specific interactions and the chains are only loosely connected into a three-dimensional structure. Crystallog. data are given.

Acta Crystallographica, Section C: Crystal Structure Communications published new progress about Crystal structure. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Safety of 5-Bromo-2-methyl-4-nitroimidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem