Category: 188637-75-4

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (6-Chloropyridin-2-yl)methanamine, is researched, Molecular C6H7ClN2, CAS is 188637-75-4, about Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group, the main research direction is morpholine aspartate HIV protease inhibitor preparation; HIV; MK-8718; inhibitor; protease.Name: (6-Chloropyridin-2-yl)methanamine.

A novel HIV protease inhibitor was designed using a morpholine core as the aspartate binding group. Anal. of the crystal structure of the initial lead bound to HIV protease enabled optimization of enzyme potency and antiviral activity. This afforded a series of potent orally bioavailable inhibitors of which MK-8718 was identified as a compound with a favorable overall profile.

This compound((6-Chloropyridin-2-yl)methanamine)Name: (6-Chloropyridin-2-yl)methanamine was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (6-Chloropyridin-2-yl)methanamine, is researched, Molecular C6H7ClN2, CAS is 188637-75-4, about Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group, the main research direction is morpholine aspartate HIV protease inhibitor preparation; HIV; MK-8718; inhibitor; protease.Name: (6-Chloropyridin-2-yl)methanamine.

A novel HIV protease inhibitor was designed using a morpholine core as the aspartate binding group. Anal. of the crystal structure of the initial lead bound to HIV protease enabled optimization of enzyme potency and antiviral activity. This afforded a series of potent orally bioavailable inhibitors of which MK-8718 was identified as a compound with a favorable overall profile.

This compound((6-Chloropyridin-2-yl)methanamine)Name: (6-Chloropyridin-2-yl)methanamine was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cox, Robert M.; Toots, Mart; Yoon, Jeong-Joong; Sourimant, Julien; Ludeke, Barbara; Fearns, Rachel; Bourque, Elyse; Patti, Joseph; Lee, Edward; Vernachio, John; Plemper, Richard K. published an article about the compound: (6-Chloropyridin-2-yl)methanamine( cas:188637-75-4,SMILESS:NCC1=NC(Cl)=CC=C1 ).Related Products of 188637-75-4. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:188637-75-4) through the article.

Respiratory syncytial virus (RSV) represents a significant health threat to infants and to elderly or immunocompromised individuals. There are currently no vaccines available to prevent RSV infections, and disease management is largely limited to supportive care, making the identification and development of effective antiviral therapeutics against RSV a priority. To identify effective chem. scaffolds for managing RSV disease, we conducted a high-throughput anti-RSV screen of a 57,000-compound library. We identified a hit compound that specifically blocked activity of the RSV RNA-dependent RNA polymerase (RdRp) complex, initially with moderate low-micromolar potency. Mechanistic characterization in an in vitro RSV RdRp assay indicated that representatives of this compound class block elongation of RSV RNA products after initial extension by up to three nucleotides. Synthetic hit-to-lead exploration yielded an informative 3D quant. structure-activity relationship (3D-QSAR) model and resulted in analogs with more than 20-fold improved potency and selectivity indexes (SIs) of >1,000. However, first-generation leads exhibited limited water solubility and poor metabolic stability. A second optimization strategy informed by the 3D-QSAR model combined with in silico pharmacokinetics (PK) predictions yielded an advanced lead, AVG-233, that demonstrated nanomolar activity against both laboratory-adapted RSV strains and clin. RSV isolates. This anti-RSV activity extended to infection of established cell lines and primary human airway cells. PK profiling in mice revealed 34% oral bioavailability of AVG-233 and sustained high drug levels in the circulation after a single oral dose of 20 mg/kg. This promising first-in-class lead warrants further development as an anti-RSV drug.

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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Quality Control of (6-Chloropyridin-2-yl)methanamine. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (6-Chloropyridin-2-yl)methanamine, is researched, Molecular C6H7ClN2, CAS is 188637-75-4, about Discovery of “”Molecular Switches”” within a Series of mGlu5 Allosteric Ligands Driven by a “”Magic Methyl”” Effect Affording Both PAMs and NAMs with In Vivo Activity, Derived from an M1 PAM Chemotype. Author is Barbaro, Lisa; Rodriguez, Alice L.; Blevins, Ashlyn N.; Dickerson, Jonathan W.; Billard, Natasha; Boutaud, Olivier; Rook, Jerri L.; Niswender, Colleen M.; Conn, P. Jeffrey; Engers, Darren W.; Lindsley, Craig W..

In the course of optimizing an M1 PAM chemotype, introduction of an ether moiety unexpectedly abolished M1 PAM activity while engendering a “”mol. switch”” to afford a weak, pure mGlu5 PAM. Further optimization was able to deliver a potent I [R = (5-fluoro-2-pyridyl), 3-methyl-2-pyridyl, etc.] (mGlu5 EC50 = 520 nM, 63% Glu Max), centrally penetrant (Kp = 0.83), MPEP-site binding mGlu5PAM I [R = (5-fluoro-2-pyridyl)] (VU6036486) that reversed amphetamine-induced hyperlocomotion. A pronounced “”magic methyl”” effect was noted with a regioisomeric Me congener, leading to a change in pharmacol. to afford a potent II [R1 = 3-pyridyl, (5-methyl-3-pyridyl), (4-methyl-3-pyridyl), etc] (mGlu5 IC50 = 110 nM, 3% Glu Min), centrally penetrant (Kp = 0.94), MPEP-site binding NAM II [R1 = 3-pyridyl] (VU6044766) that displayed anxiolytic activity in a mouse marble burying assay. These data further support the growing body of literature concerning the existence of G protein-coupled receptor (GPCR) allosteric privileged structures, and the value and impact of subtle Me group walks, as well as the highly productive fluorine walk, around allosteric ligand cores to stabilize unique GPCR conformations.

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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Bioorganic & Medicinal Chemistry Letters called Amyloidogenic immunoglobulin light chain kinetic stabilizers comprising a simple urea linker module reveal a novel binding sub-site, Author is Yan, Nicholas L.; Nair, Reji; Chu, Alan; Wilson, Ian A.; Johnson, Kristen A.; Morgan, Gareth J.; Kelly, Jeffery W., which mentions a compound: 188637-75-4, SMILESS is NCC1=NC(Cl)=CC=C1, Molecular C6H7ClN2, Computed Properties of C6H7ClN2.

In Ig light chain (LC) amyloidosis, the misfolding, or misfolding and misassembly of LC a protein or fragments thereof resulting from aberrant endoproteolysis, causes organ damage to patients. A small mol. “”kinetic stabilizer”” drug could slow or stop these processes and improve prognosis. We previously identified coumarin-based kinetic stabilizers of LCs that can be divided into four components, including a “”linker module”” and “”distal substructure””. Our prior studies focused on characterizing carbamate, hydantoin, and spirocyclic urea linker modules, which bind in a solvent-exposed site at the VL-VL domain interface of the LC dimer. Here, we report structure-activity relationship data on 7-diethylamino coumarin-based kinetic stabilizers. This substructure occupies the previously characterized “”anchor cavity”” and the “”aromatic slit””. The potencies of amide and urea linker modules terminating in a variety of distal substructures attached at the 3-position of this coumarin ring were assessed. Surprisingly, crystallog. data on a 7-diethylamino coumarin-based kinetic stabilizer reveals that the urea linker module and distal substructure attached at the 3-position bind a solvent-exposed region of the full-length LC dimer distinct from previously characterized sites. Our results further elaborate the small-mol. binding surface of LCs that could be occupied by potent and selective LC kinetic stabilizers.

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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 188637-75-4, is researched, SMILESS is NCC1=NC(Cl)=CC=C1, Molecular C6H7ClN2Journal, Article, Organic Letters called Direct Catalytic Asymmetric α-Allylic Alkylation of Aza-aryl Methylamines by Chiral-Aldehyde-Involved Ternary Catalysis System, Author is Zhu, Fang; Shen, Qi-Wen; Wang, Wen-Zhe; Wu, Zhu-Lian; Cai, Tian; Wen, Wei; Guo, Qi-Xiang, the main research direction is allyl alc ester heteroaryl methylamine chiral aldehyde allylic alkylation; tertiary butyl quinolinyl arylbutenyl carbamate preparation enantioselective.Recommanded Product: 188637-75-4.

A ternary catalytic system comprising a chiral aldehyde, a transition metal, and a Lewis acid was rationally designed for the asym. α-allylic alkylation reaction of aza-aryl methylamines and π-allylmetal electrophiles. Structural diversity chiral amines bearing carbon-carbon double bonds and aza-heterocycles were produced in moderate to good yields with good to excellent enantioselectivities. These products was readily converted into other chiral amines without the loss of enantioselectivity. A reasonable reaction mechanism was proposed to illustrate the stereoselective control results.

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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of the American Chemical Society called Synergetic Organocatalysis for Eliminating Epimerization in Ring-Opening Polymerizations Enables Synthesis of Stereoregular Isotactic Polyester, Author is Li, Maosheng; Tao, Yue; Tang, Jiadong; Wang, Yanchao; Zhang, Xiaoyong; Tao, Youhua; Wang, Xianhong, which mentions a compound: 188637-75-4, SMILESS is NCC1=NC(Cl)=CC=C1, Molecular C6H7ClN2, Name: (6-Chloropyridin-2-yl)methanamine.

Ring-opening polymerization of O-carboxyanhydrides (OCAs) can furnish polyesters with a diversity of functional groups that are traditionally hard to harvest by polymerization of lactones. Typical ring-opening catalysts are subject to unavoidable racemization of most OCA monomers, which hampers the synthesis of highly isotactic crystalline polymers. Here, we describe an effective bifunctional single-mol. organocatalysis for selective ring-opening polymerization of OCAs without epimerization. The close vicinity of both activating groups in the same mol. engenders an amplified synergetic effect and thus allows for the use of mild bases, thereby leading to minimal epimerization for polymerization Ring-opening polymerization of manOCA monomer (OCA from mandelic acid) mediated by the bifunctional single-mol. organocatalyst yields highly isotactic poly(mandelic acid) (PMA) with controlled mol. weights (up to 19.8 kg mol-1). Mixing of the two enantiomers of PMA generates the first example of a crystalline stereocomplex in this area, which displayed distinct Tm values around 150 °C. Remarkably, the bifunctional catalysts are moisture-stable, recyclable, and easy to use, allowing sustainable and scalable synthesis of a stereoregular functional polyester.

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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Quality Control of (6-Chloropyridin-2-yl)methanamine. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (6-Chloropyridin-2-yl)methanamine, is researched, Molecular C6H7ClN2, CAS is 188637-75-4, about Synthesis and Cyclic Voltammetry Studies of Copper Complexes of Bromo- and Alkoxyphenyl-Substituted Derivatives of Tris(2-pyridylmethyl)amine: Influence of Cation-Alkoxy Interactions on Copper Redox Potentials. Author is Chuang, Chang-Lin; dos Santos, Osvaldo; Xu, Xiaodong; Canary, James W..

A combination of host-guest chem. and coordination chem. in the design of electrochem. sensors for alkali metal and ammonium ions is described. The sensor mols. are coordination complexes between a Cu ion and a functionalized tripodal ligand. Upon presentation of the ion to the sensor mol., a shift in the redox potential of the Cu ion occurs. In the study, three new alkoxyphenyl-substituted derivatives of the ligand tris(2-pyridylmethyl)amine (TPA) were prepared and characterized. The synthesis of the new ligands involved the preparation of bromopyridyl-TPA derivatives followed by Suzuki coupling with substituted phenylboronic acids. Cyclic voltammetry studies of Cu complexes of the ligands indicated that steric effects played a dominant role in the overall determination of the Cu redox couple. Studies of the alkoxyphenyl ligands indicated that small but reproducible changes in the Cu redox couple occurred upon presentation of a guest cation that would be expected to form a complex with the Cu-ligand complex.

From this literature《Synthesis and Cyclic Voltammetry Studies of Copper Complexes of Bromo- and Alkoxyphenyl-Substituted Derivatives of Tris(2-pyridylmethyl)amine: Influence of Cation-Alkoxy Interactions on Copper Redox Potentials》,we know some information about this compound(188637-75-4)Quality Control of (6-Chloropyridin-2-yl)methanamine, but this is not all information, there are many literatures related to this compound(188637-75-4).

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem