Category: 1849-02-1

Application of 1849-02-1, The chemical industry reduces the impact on the environment during synthesis 1849-02-1, name is 2-Chloro-1-methyl-1H-benzo[d]imidazole, I believe this compound will play a more active role in future production and life.

b. 1-methyl-2-(Piperazin-1-yl)-benzimidazole A mixture of 1 g (6.02 mmol) of 2-chloro-1-methyl-benzimidazole and 2.58 g (30 mmol) of piperazine is heated to 150C. without a solvent. The cooled melt is combined successively with water and dilute hydrochloric acid and extracted with dichloromethane. Then the aqueous phase is made alkaline with dilute sodium hydroxide solution and extracted with dichloromethane. The organic phase is dried over sodium sulphate and concentrated by evaporation. The product is purified by column chromatography on silica gel (eluant: dichloromethane/ethanol/ammonia=5:1:0.1). Yield: 0.4 g (30.8% of theory), Melting point: 99 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-1-methyl-1H-benzo[d]imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Lehmann-Lintz, Thorsten; Heckel, Armin; Thomas, Leo; Mark, Michael; US2003/166637; (2003); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1849-02-1, name is 2-Chloro-1-methyl-1H-benzo[d]imidazole, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 1849-02-1

EXAMPLE 39; CYCLOHEXYL-ETHYL- {2- [4- (1-METHYL-1 H-BENZOIMIDAZOL-2-YLOXY)-PHENYL]-ETHYL}- amine; A mixture of 4- [2- (cyclohexyl-ethyl-amino)-ethyl]-phenol (247 mg, 1.0 MMOL), N- methyl benzimidazole (EXAMPLE 8 ; 200 mg, 1.2 MMOL), and CS2CO3 (652 mg, 2.0 MMOL) in DMF (3 mL) was stirred at 100 C for 16 h. The reaction mixture was cooled and filtered through diatomaceous earth, which was then washed with ethyl acetate (30 mL). The combined filtrates were washed with H20 (3 x 10 mL) then brine (10 mL), dried (NA2SO4), filtered, and concentrated under reduced pressure. The crude material was purified on SI02 (10 g; 0-100% 10% [2 M NH3 in CH30H] in CH2CI2/CH2C12) to provide 105 mg (28% yield) of a brown oil. MS (ESI) : mass calculated for C24H3INSO, 377.53 ; M/Z FOUND, 378.4 [M+H] +. H NMR (400 MHz, CDC13) : 7.52 (d, J =7. 2, 1 H), 7.63-7. 58 (m, 1 H), 7.33-7. 18 (m, 7H), 3.75 (s, 3H), 2.81-2. 70, m, 4H), 2.68 (q, J = 7.1, 2H), 2.60- 2.50 (m, 1H), 1. 90-1. 80 (m, 4H), 1.67 (d, J : = 12.3, 1 H), 1.35-1. 18 (m, 4H), 1.15-1. 05 (m, 1H), 1.12 (t, J=7. 1, 3H)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1849-02-1.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2005/12296; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 1849-02-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1849-02-1, name is 2-Chloro-1-methyl-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Step 2 0.43 g (5.0 mmol) of piperazine and 0.24 g (1.0 mmol) of the compound obtained in Step 1 were placed in a dried round flask provided with nitrogen gas, followed by reacting the mixture at 150C for 30 mins. After cooling to room temperature, the reaction mixture was acidified with IN-HCl solution and washed with dichloromethane. The water layer was treated with IN-NaOH solution and extracted with dichloromethane. The formed organic layer was dried over anhydrous magnesium sulfate and concentrated under a reduced pressure, and the resulting residue was subjected to silica gel column chromatography (dichloromethaneimethanol^il) to obtain 0.15 g of l-methyl-2-(piperazin-l-yl)-benzoimidazole (yield: 69%).

The synthetic route of 2-Chloro-1-methyl-1H-benzo[d]imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; CHEMON INC.; WO2008/153325; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem