Category: 1792-40-1

Reference of 1792-40-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1792-40-1, name is 2-Methyl-5-nitro-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 5-nitrobenzimidazole (1.0 G, 5.6 MMOL) in acetone (50 mL) was added potassium carbonate (1.0 g), followed by alkyl halide (1.2-1. 5 equivalents). The mixture was stirred under nitrogen at rt, then partitioned between ethyl acetate and water after TLC showed completion of the reaction. The organic phase was washed with brine, dried over sodium sulphate and concentrated in vacuo to give a mixture of 1-ALKYL- 5-NITRO-2-METHYLBENZIMIDAZOLE and 1-alkyl-6-nitro-2-methylbenzimidazole, which were dissolved in ethanol-THF (100 mL, 2: 1) and hydrogenated over 5% Pd-C under atmosphere pressure for 8h. After filtration through celte, the filtrate was evaporated to give a yellow solid that was separated with flash chromatography (Methanol-DCM gradient elution). 1-Alkyl-5-aminobenzimidazole and 1-alkyl-6-aminobenzimidazole were obtained as yellow solid or thick syrup.; 5-Amino-1, 2-DIMETHYLBENZIMIDAZOLE (XDS01191B, XDS02082B): Yellow solid, mp 126-127C (LIT. 128C, [23] ). TLC single spot at Rf 0.30 (5% methanol/DCM) ;’H NMR (270 MHz, DMSO): 6 7.08 (1H, d, J = 8.7 Hz, 7-H), 7.65 (1H, d, J = 1.5 Hz, 4-H), 6.50 (1H, dd, J = 8.7, 1.5 Hz, 6-H), 4.63 (2H, broad, NH2), 3.58 (3H, s, NCH3), 2.39 (3H, s, CH3). 6-Amino-1, 2-DIMETHYLBENZIMIDAZOLE (XDS01191A, XDS02082A): Yellow solid. TLC single spot at Rf 0.33 (5% methanol/DCM) ;’H NMR (270 MHz, DMSO): 6 7. 13 (1H, d, J = 8.4 Hz, 4-H), 6.48 (1H, d, J = 2. 0 Hz, 7-H), 6.43 (1H, dd, J = 8.4, 2.0 Hz, 5-H), 4.83 (2H, broad, NH2), 3.53 (3H, s, NCH3), 2.39 (3H, s, CH3).

The synthetic route of 2-Methyl-5-nitro-1H-benzo[d]imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; STERIX LIMITED; WO2004/37251; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 1792-40-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1792-40-1, name is 2-Methyl-5-nitro-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

In a 150 mL round-bottomed flask, the benzimidazole compound represented by Formula III (R1 is methyl, R2 is H, R3 is nitro) (0.361 g, 2.04 mmol) was added, and potassium carbonate was used as a base (0.324 g, 2.35 mmol) of acetonitrile as solvent. After stirring at 70C for 30 minutes, the mixture was cooled to room temperature and Compound II (0.400 g, 1.57 mmol) was added to continue the reaction and the temperature was raised to 70C. TLC followed the reaction to completion. After concentration, extraction, column chromatography, drying and other post-treatments, compound IV-3 (0.449 g) was obtained with a yield of 66.1%.

The synthetic route of 2-Methyl-5-nitro-1H-benzo[d]imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Southwest University; Zhou Chenghe; Man Nabaonei·lamohan·laao·yadafu; Ge Pala·lawaya; Wang Yanan; Fang Xuejie; (27 pag.)CN107721933; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 1792-40-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1792-40-1, name is 2-Methyl-5-nitro-1H-benzo[d]imidazole, This compound has unique chemical properties. The synthetic route is as follows.

(95a) Using conditions analogous to (1f), 2-methyl-5-nitro-benzimidazole (101 mg, 0.568 mmol) was reacted with methyl 4-(bromomethyl)-benzoate to provide the desired ester (71 mg, 40%). MS found: (M+H)+=326.

The chemical industry reduces the impact on the environment during synthesis 2-Methyl-5-nitro-1H-benzo[d]imidazole. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Ott, Gregory R.; Chen, Xiao-Tao; Duan, Jingwu; Lu, Zhonghui; US2003/139388; (2003); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 1792-40-1,Some common heterocyclic compound, 1792-40-1, name is 2-Methyl-5-nitro-1H-benzo[d]imidazole, molecular formula is C8H7N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In 100mL round bottom flask, 2-methyl-5-nitrobenzimidazole (0. 46g, 0. 0027mol), potassium carbonate (0. 75g, 0. 0054mol) and the amount of acetonitrile, temperature control The reaction was stirred 50 C 0. 5h, cooled to room temperature, II-1 (1. 00g, 0. 0027mol) was heated to 80 C and stirring continued, until thin layer chromatography the reaction was completed track, and then by concentration, extraction, column chromatographic separation, recrystallization, and dried to give square 0. 31g Compound 1-29, yield 32.1%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methyl-5-nitro-1H-benzo[d]imidazole, its application will become more common.

Reference:
Patent; Southwest University; Zhou, Chenghe; Zhang, Ling; (39 pag.)CN104086534; (2016); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 1792-40-1, The chemical industry reduces the impact on the environment during synthesis 1792-40-1, name is 2-Methyl-5-nitro-1H-benzo[d]imidazole, I believe this compound will play a more active role in future production and life.

In 100mL round bottom flask, 2-methyl-5-nitrobenzimidazole (0. 46g, 0. 0026mol), potassium carbonate (0 · 72g, 0 · 0052mol) and the amount of acetonitrile, temperature control The reaction was stirred 50 C 0 · 5h, cooled to room temperature, was added II-2 (1. 00g, 0. 0026mol) was heated to 80 C and stirring continued, until thin layer chromatography the reaction was completed track, and then by concentration, extraction, column chromatographic separation, recrystallization, and dried to give square 0. 49g Compound 1-30, yield 33.4%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methyl-5-nitro-1H-benzo[d]imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Southwest University; Zhou, Chenghe; Zhang, Ling; (39 pag.)CN104086534; (2016); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 1792-40-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1792-40-1, name is 2-Methyl-5-nitro-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 5-nitrobenzimidazole (1.0 G, 5.6 MMOL) in acetone (50 mL) was added potassium carbonate (1.0 g), followed by alkyl halide (1.2-1. 5 equivalents). The mixture was stirred under nitrogen at rt, then partitioned between ethyl acetate and water after TLC showed completion of the reaction. The organic phase was washed with brine, dried over sodium sulphate and concentrated in vacuo to give a mixture of 1-ALKYL- 5-NITRO-2-METHYLBENZIMIDAZOLE and 1-alkyl-6-nitro-2-methylbenzimidazole, which were dissolved in ethanol-THF (100 mL, 2: 1) and hydrogenated over 5% Pd-C under atmosphere pressure for 8h. After filtration through celte, the filtrate was evaporated to give a yellow solid that was separated with flash chromatography (Methanol-DCM gradient elution). 1-Alkyl-5-aminobenzimidazole and 1-alkyl-6-aminobenzimidazole were obtained as yellow solid or thick syrup.; 5-Amino-1, 2-DIMETHYLBENZIMIDAZOLE (XDS01191B, XDS02082B): Yellow solid, mp 126-127C (LIT. 128C, [23] ). TLC single spot at Rf 0.30 (5% methanol/DCM) ;’H NMR (270 MHz, DMSO): 6 7.08 (1H, d, J = 8.7 Hz, 7-H), 7.65 (1H, d, J = 1.5 Hz, 4-H), 6.50 (1H, dd, J = 8.7, 1.5 Hz, 6-H), 4.63 (2H, broad, NH2), 3.58 (3H, s, NCH3), 2.39 (3H, s, CH3). 6-Amino-1, 2-DIMETHYLBENZIMIDAZOLE (XDS01191A, XDS02082A): Yellow solid. TLC single spot at Rf 0.33 (5% methanol/DCM) ;’H NMR (270 MHz, DMSO): 6 7. 13 (1H, d, J = 8.4 Hz, 4-H), 6.48 (1H, d, J = 2. 0 Hz, 7-H), 6.43 (1H, dd, J = 8.4, 2.0 Hz, 5-H), 4.83 (2H, broad, NH2), 3.53 (3H, s, NCH3), 2.39 (3H, s, CH3).

The synthetic route of 2-Methyl-5-nitro-1H-benzo[d]imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; STERIX LIMITED; WO2004/37251; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 1792-40-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1792-40-1, name is 2-Methyl-5-nitro-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

In a 150 mL round-bottomed flask, the benzimidazole compound represented by Formula III (R1 is methyl, R2 is H, R3 is nitro) (0.361 g, 2.04 mmol) was added, and potassium carbonate was used as a base (0.324 g, 2.35 mmol) of acetonitrile as solvent. After stirring at 70C for 30 minutes, the mixture was cooled to room temperature and Compound II (0.400 g, 1.57 mmol) was added to continue the reaction and the temperature was raised to 70C. TLC followed the reaction to completion. After concentration, extraction, column chromatography, drying and other post-treatments, compound IV-3 (0.449 g) was obtained with a yield of 66.1%.

The synthetic route of 2-Methyl-5-nitro-1H-benzo[d]imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Southwest University; Zhou Chenghe; Man Nabaonei·lamohan·laao·yadafu; Ge Pala·lawaya; Wang Yanan; Fang Xuejie; (27 pag.)CN107721933; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1792-40-1, name is 2-Methyl-5-nitro-1H-benzo[d]imidazole, A new synthetic method of this compound is introduced below., Recommanded Product: 2-Methyl-5-nitro-1H-benzo[d]imidazole

To a solution of 2-methyl-5-nitro-1H-benzimidazole (2) (9.0 g,0.05 mol) in ethanol (50 mL), K2CO3 (6.98 g, 0.075 mol) and benzylchloride (9.63 g, 0.075 mol) were refluxed for 8 h. After the completionof the reaction (monitored by TLC), the reaction mixturewas filtered and concentrated to give yellow solid. The residualmass was crystallized from ethanol to give mixture of 1-benzyl-2-methyl-5-nitro-1H-benzimidazole and 3-benzyl-2-methyl-5-nitro-3H-benzimidazole (3) in 75% yield. To a suspension of SnCl2 2H2O (15.45 g, 0.067 mol) in 2 N HCl (47.6 mL), 1/3-benzyl-2-methyl-5-nitro-1H/3H-benzimidazole (3) (4.25 g, 0.019 mol)was heated at 110 C for 7 h. After completion of the reaction,the suspension was neutralized with 2 N NaOH and diluted withethanol. Filtered the solid product and extracted the filtrate with chloroform, dried over Na2SO4, filtered and concentrated to getmixture of products which were separated through column chromatographyusing ethyl acetate/methanol (19:1) as eluent to getsolid compounds 4a and 4b.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Singla, Prinka; Luxami, Vijay; Paul, Kamaldeep; Bioorganic and Medicinal Chemistry; vol. 23; 8; (2015); p. 1691 – 1700;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 1792-40-1,Some common heterocyclic compound, 1792-40-1, name is 2-Methyl-5-nitro-1H-benzo[d]imidazole, molecular formula is C8H7N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 2-methyl-5-nitro-1H-benzimidazole (0.7 g, 4 mmol), (Boc)2O (4.4 mol) and NaHCO3 (4.4 mol) in methanol (30 ml) was stirred at rt for 24 h. The solid was filtered then the solvent was evaporated and purified by column chromatography (petroleum ether/ethyl acetate, 10:1) gave 8 (0.86 g, 78%) as white solid, mp 134-136 C. 1H NMR (300 MHz, CDCl3 delta 1.43 (s, 9H, 3CH3), 2.50 (s, 3H, CH3), 7.61 (d, J = 9 Hz, 1H, H7), 8.02 (d, J = 9 Hz, 1H, H6), 8.34 (s, 1H, H4). 13C NMR (75 MHz, CDCl3 delta 14.9, 28.6, 84.1, 84.3, 85.7, 113.3, 116.8, 119.0, 137.0, 138.2, 140.1, 145.0, 148.1 ppm. MS (EI) m/z (%): 277.11 (20, M+), 176 (100, M-101). Anal. Calcd for C13H15N3O4: C, 56.31; H, 5.45; N, 15.15. Found: C, 56.50; H, 5.27; N, 15.10.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methyl-5-nitro-1H-benzo[d]imidazole, its application will become more common.

Reference:
Article; El-Nezhawy, Ahmed O.H.; Biuomy, Ayman R.; Hassan, Fatma S.; Ismaiel, Ayman K.; Omar, Hany A.; Bioorganic and Medicinal Chemistry; vol. 21; 7; (2013); p. 1661 – 1670;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1792-40-1, name is 2-Methyl-5-nitro-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 2-Methyl-5-nitro-1H-benzo[d]imidazole

General procedure: Conventional Method. A solution of KOH (0.01mol) in water (20 mL) and CS2 (0.01 mol) was added to solution of 4a-d (0.01 mol) in ethanol (20 mL) and then, the mixture was refluxed for 4 hours. After the reaction was completed, monitored by TLC (Ethyl acetate: Hexane, 3:1), the mixturewas cooled down to room temperature and neutralized with diluted HCl (4N). The mixture was left to cool down and the precipitated product was filtrated, washed with H2O andrecrystallized from ethanol. Microwave Method. A solution of 4a-d (0.01 mol) in ethanol(10 mL) and KOH (0.01 mol) in water (5 mL) were taken in a microwave process vial. Then, the mixture was heated under microwave irradiation 300 Watt at 100 C, with stirring and air-jet cooling for 5 min. After the mixture was cooled down, CS2 (0.01 mol) was added to the mixture and then, heated again 300 Watt at 100 C. Completion of reaction was achieved in 10 min. as indicated by TLC. Then, the mixture was neutralized with 4 N HCl and left to cool. The precipitated product was filtrate, washed with H2O and recrystallized from ethanol. 5-[(2-Methyl-5(6)-nitro-1H-benzimidazole-1-yl)methyl]-1,3,4-oxadiazole-2-thiol (5a) M.p. 249-250 C. IR (KBr), nu/cm-1: 3021, 2968, 2698, 1618,1518, 1343, 1250, 1145. 1H-NMR (DMSO-d6, 200 MHz) delta: 14.22 (s, 1H, SH), 8.44 (s, 1H, Ar-H), 8.18 (d, 1H, Ar-H,J=8.8), 7.86 (d, 1H, Ar-H, J=8.8), 5.71 (s, 2H, CH2), 2.42 (s,3H, CH3) ppm. 13C NMR (DMSO-d6, 50 MHz) delta: 14.29, 43.24, 111.38, 115.09, 118.64, 136.14, 142.14, 143.66,157.43, 159.50, 178.73 ppm. Anal. Calcd. For C11H9N5O3S: C, 45.36; H, 3.11; N, 24.04; S, 11.01; Found: C, 45.38; H,3.13; N, 24.05; S, 11.02; ESI-MS: m/z: 292 [M]+.

The synthetic route of 1792-40-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kahveci, Bahittin; Sosan, Nesibe; Mentese, Emre; Yilmaz, Fatih; Revue Roumaine de Chimie; vol. 58; 6; (2013); p. 511 – 515;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem