Category: 177843-26-4

September 23, 2021 News Introduction of a new synthetic route about 177843-26-4

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1H-benzo[d]imidazol-5-amine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 177843-26-4, name is 4-Bromo-1H-benzo[d]imidazol-5-amine, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 177843-26-4, SDS of cas: 177843-26-4

5-(methylthio)-3,4-dihydro-2H-pyrrole (238mg) was combined with of 1 H-benzimidazol- 6-amine, 7-bromo (430 mg) (CAS 177843-26-4) in 10 mL of isopropyl alcohol. The reaction was stirred at reflux for 4 days. The refluxed mixture was then cooled to room temperature and concentrated. Flash column chromatography (4-6% 7N NH3 in MeOH/DCM) yielded the title compound 1 H NMR (300 MHz, CD3OD) delta 2.08 (m, 2H), 2.55 (t, J=7.92Hz, 2H), 3.39 (t, J=6.74Hz, 2H), 6.93 (d, J=8.50Hz, 1 H), 7.50 (d, J=8.50Hz, 1 H), 8.1 1 (s, 1 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1H-benzo[d]imidazol-5-amine, and friends who are interested can also refer to it.

Reference:
Patent; ALLERGAN, INC.; CHOW, Ken; GIL, Daniel W.; DONELLO, John E.; WANG, Liming; CORPUZ, Evelyn G.; FANG, Wenkui K.; SINHA, Santosh C.; DIBAS, Mohammed I.; WO2011/44229; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Introduction of a new synthetic route about 4-Bromo-1H-benzo[d]imidazol-5-amine

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1H-benzo[d]imidazol-5-amine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 177843-26-4, name is 4-Bromo-1H-benzo[d]imidazol-5-amine, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 177843-26-4, COA of Formula: C7H6BrN3

5-(methylthio)-3,4-dihydro-2H-pyrrole (238mg) was combined with of 1 H-benzimidazol- 6-amine, 7-bromo (430 mg) (CAS 177843-26-4) in 10 mL of isopropyl alcohol. The reaction was stirred at reflux for 4 days. The refluxed mixture was then cooled to room temperature and concentrated. Flash column chromatography (4-6% 7N NH3 in MeOH/DCM) yielded the title compound 1 H NMR (300 MHz, CD3OD) delta 2.08 (m, 2H), 2.55 (t, J=7.92Hz, 2H), 3.39 (t, J=6.74Hz, 2H), 6.93 (d, J=8.50Hz, 1 H), 7.50 (d, J=8.50Hz, 1 H), 8.1 1 (s, 1 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1H-benzo[d]imidazol-5-amine, and friends who are interested can also refer to it.