Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 176721-01-0, name is (2,3-Dimethylphenyl)(1-trityl-1H-imidazol-5-yl)methanol, A new synthetic method of this compound is introduced below., Safety of (2,3-Dimethylphenyl)(1-trityl-1H-imidazol-5-yl)methanol
The compound of formula IV (50 g, 0.11 mol) was added to 1,4-dioxane (750 mL).Add MnO2 (100g,1.15mol),Warming up to reflux,Reaction for 3h,The reaction is complete,Hot filtered,The filtrate is concentrated and dried.Obtained a crude white solid,Add methanol (350mL) at room temperature (25 C) for 1-2h,filter,Vacuum drying to give a white solid compound of formula V (45 g).Yield: 90.0%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Shanghai Tianci International Pharmaceutical Co., Ltd.; Chi Wangzhou; Sha Fei; (11 pag.)CN109912508; (2019); A;,
Imidazole – Wikipedia,
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