Synthesis of (E)-imidazo[1,2-a]pyridylvinyl sulfones was written by Gautier, Arnaud;Roche, Danielle;Teulade, Jean Claude;Madesclaire, Michel. And the article was included in Sulfur Letters in 1995.Formula: C9H7BrN2O The following contents are mentioned in the article:
Wittig-Horner and Peterson reactions provide heterocyclic vinyl sulfones I (R1 = H, Me, R2 = H, Br, R3 = Ph, Me) and II from 2- and 3-imidazo[1,2-a]pyridinecarbaldehydes with satisfactory yields. Only the (E)-isomer is obtained after purification These compounds are major potential cardiovascular agents. This study involved multiple reactions and reactants, such as 3-Bromo-8-methylimidazo[1,2-a]pyridine-2-carbaldehyde (cas: 175878-06-5Formula: C9H7BrN2O).
3-Bromo-8-methylimidazo[1,2-a]pyridine-2-carbaldehyde (cas: 175878-06-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Formula: C9H7BrN2O
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem