Category: 17450-34-9

These common heterocyclic compound, 17450-34-9, name is Ethyl 2-(1-Imidazolyl)acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 17450-34-9

Take the above compounds Intermediate 1 is 7.7g (0.05mol) was dissolved in 100mL of water, concentrated hydrochloric acid to adjust the pH value of 1.5, refluxed for 7h at 100 deg.] C, After completion of the reaction, the resultant reaction liquid was distilled under reduced pressure at 25 deg.] C directly to the not drop out of the droplet, was added 300 mL of acetone to give a white solid was filtered and recrystallized from isopropanol to give white crystals, i.e. intermediate compound 2;

The synthetic route of Ethyl 2-(1-Imidazolyl)acetate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jiangsu Atomic Medical Institute; Lin Jianguo; Peng Ying; Qiu Ling; Lv Gaochao; Li Ke; Luo Shineng; Zhao Xueyu; Wang Shanshan; (22 pag.)CN106749405; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 17450-34-9, name is Ethyl 2-(1-Imidazolyl)acetate, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17450-34-9, Formula: C7H10N2O2

Under a dry argon atmosphere, a solution of 2 (6.05g, 39.2mmol) in dry THF (20mL) was added dropwise to the mixture of lithium aluminum hydride (3.00g, 79.1mmol) and dry THF (60mL) at 0C. The reaction mixture was stirred for 5min at 0C and for 4h at room temperature. Then, water (3mL), 15% sodium hydroxide aqueous solution (3mL), and water (9mL) were separately added dropwise to the reaction mixture at 0C. The resulting reaction mixture was stirred at room temperature for 12h and filtered. The filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography eluted with a mixed solvent of chloroform/methanol (10/1v/v). The fraction with an Rf value of 0.22 was collected and purified by distillation under reduced pressure twice to afford 1-(2-hydroxyethyl)imidazole (Im2OH) as colorless oil (2.386g, 54%)

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Reference:
Article; Ichikawa, Tsukasa; Wako, Tsuyoshi; Nemoto, Nobukatsu; Reactive and functional polymers; vol. 99; (2016); p. 1 – 8;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem