Category: 1739-84-0

Reference of 1739-84-0, A common heterocyclic compound, 1739-84-0, name is 1,2-Dimethyl-1H-imidazole, molecular formula is C5H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 1,2-dimethyl-1H-imidazole (1a) (96 mg, 1 mmol) in DMF (5 mL), was added NBS (169 mg, 0,95 mmol) and the resulting reaction mixture was stirred in the dark at room temperature for 3 h. The orange-yellowish solution thus obtained was diluted with EtOAc (50 mL), washed with a 10% aqueous solution of NaOH (2 x 50 mL), water (50 mL) and brine (50 mL). The aqueous phases were back-extracted with EtOAc (50 mL) and the combined organic phases dried over Na2SO4 and filtered. The solvent was removed at reduced pressure, affording the title compound as colorless crystals (3.78 g, 76%).

The synthetic route of 1739-84-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bellina, Fabio; Lessi, Marco; Marianetti, Giulia; Panattoni, Alessandro; Tetrahedron Letters; vol. 56; 25; (2015); p. 3855 – 3857;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 1739-84-0, name is 1,2-Dimethyl-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1739-84-0, SDS of cas: 1739-84-0

General procedure: Quaternization of 1,2-dimethylimidazole withalkyl halides was performed in acetonitrile (50% solution)at the boiling point of the solvent and an equimolarratio of the starting reagents for 48 h. The solvent was then removed, and lithium bis(trifluoromethylsulfonyl)imide (10% excess) in water (30% solution) was added to the solid residue, and the reaction mixture was stirred for 30 min. The desired product precipitated from water into the lower liquid phase. The upper aqueous layer was decanted, methylene chloride (equal volume) was added to the lower layer, and the resulting solution was washed again with distilled water till negative reaction to Cl- with AgNO3. The ionic liquids were dried by azeotropic distillation of absolute methylene chloride, then the traces of the organic solvent were removed in vacuum by heating (3 h at 100C).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,2-Dimethyl-1H-imidazole, and friends who are interested can also refer to it.

Reference:
Article; Krasovskiy; Chernikova; Glukhov; Kapustin; Koroteev; Russian Journal of Physical Chemistry; vol. 92; 12; (2018); p. 2379 – 2385; Zh. Fiz. Khim.; vol. 92; 12; (2018); p. 1851 – 1858,8;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem