Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16931-35-4, name is 7-Chloro-1H-benzo[d]imidazole, A new synthetic method of this compound is introduced below., Recommanded Product: 16931-35-4
General procedure: To a solution of aryl halide (1.0 equivalence) and boronic acid (1.1 equivalence) in 1,4-Dioxane (1.0 M), was added potassium carbonate (2.0 equivalence, 2.0 M aqueous solution) followed by palladium catalyst [1,1?-bis(diphenylphoshphino)ferrocene]-dichloropalladium (II) 1:1 complex with dichloromethane (0.10 equivalence). The reaction mixture was degassed for 5 minutes by bubbling nitrogen gas directly into the solution using syringe needle. The reaction vessel was closed tightly and stirred at 100 oC for overnight or until the completion of reaction as judged by TLC. The reaction mixture was filtered through a pad of silica/celite to remove the catalyst, poured into water (25 mL) and extracted with ethyl acetate (3 x 25 mL), the organic layer was washed with water (20 mL), dried over Na2SO4 and concentrated and purified by chromatography.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Kashyap, Sudhir; Sandler, Joel; Peters, Ulf; Martinez, Eduardo J.; Kapoor, Tarun M.; Bioorganic and Medicinal Chemistry; vol. 22; 7; (2014); p. 2253 – 2260;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem