1632-83-3 Archives - Page 2 of 3 - Imidazoles-derivatives

Wang, Caihong et al. published their research in ACS Applied Energy Materials in 2021 | CAS: 1632-83-3

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Recommanded Product: 1632-83-3

Poly(ionic liquid) Bridge Joining Smectic Lamellar Conducting Channels in Photoelectrochemical Devices as High-Performance Solid-State Electrolytes was written by Wang, Caihong;Li, Xueyong;Zhou, Jiwen;Tian, Wen;Ji, Junyi;Wu, Yong;Tan, Shuai. And the article was included in ACS Applied Energy Materials in 2021.Recommanded Product: 1632-83-3 This article mentions the following:

Nanostructured ionic liquid crystals have emerged as promising electrolytes with the potential to satisfy the demands of both efficient charge transport and stability over conventional liquid electrolytes for advanced energy devices. However, traditional methods via the macroscopic orientation of ionic liquid crystals for charge transport intensification can hardly be achieved during practical device applications. Herein, a simple method was proposed to spontaneously construct long-range continuous conducting channels for significantly improving the charge transport of ionic liquid crystals in the confined space of energy devices. A poly(imidazolium ionic liquid) was designed and in situ prepared in a smectic [C14MIm][I]-based electrolyte for photoelectrochem. device fabrication. The composite solid-state electrolyte self-assembled microphase-segregation nanostructures, wherein the poly(ionic liquid) aggregated at the boundaries of layered smectic polydomains. The imidazolium iodide ions in the poly(ionic liquid) acted as imbedded ion tunnels at domain interfaces via 蟺-蟺 stacking and ionic interaction, which facilitated the charge transport crossing the interfacial gaps to join the intradomain lamellar channels as thermally stable and long-range continuous charge transport pathways. By using the poly(ionic liquid) to bridge the domain-interfacial gaps, the ion conductivity of the ionic liquid crystals was up to 7 times increased with a maximum value of 2.0 x 10^-3 S cm^-1, and the derived dye-sensitized solar cell could operate stably at 70 掳C with a 2-times enhancement and champion efficiency of 8.2%. The approach here was comparable but more processable to traditional methods via the macroscopical orientation of ionic liquid crystals for charge transport intensification within energy devices, which have great potential to develop high-performance solid-state electrolytes to achieve the best balance between efficiency and durability for energy devices. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Recommanded Product: 1632-83-3).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wang, Caihong et al. published their research in ACS Applied Energy Materials in 2021 | CAS: 1632-83-3

Nanostructured ionic liquid crystals have emerged as promising electrolytes with the potential to satisfy the demands of both efficient charge transport and stability over conventional liquid electrolytes for advanced energy devices. However, traditional methods via the macroscopic orientation of ionic liquid crystals for charge transport intensification can hardly be achieved during practical device applications. Herein, a simple method was proposed to spontaneously construct long-range continuous conducting channels for significantly improving the charge transport of ionic liquid crystals in the confined space of energy devices. A poly(imidazolium ionic liquid) was designed and in situ prepared in a smectic [C14MIm][I]-based electrolyte for photoelectrochem. device fabrication. The composite solid-state electrolyte self-assembled microphase-segregation nanostructures, wherein the poly(ionic liquid) aggregated at the boundaries of layered smectic polydomains. The imidazolium iodide ions in the poly(ionic liquid) acted as imbedded ion tunnels at domain interfaces via π-π stacking and ionic interaction, which facilitated the charge transport crossing the interfacial gaps to join the intradomain lamellar channels as thermally stable and long-range continuous charge transport pathways. By using the poly(ionic liquid) to bridge the domain-interfacial gaps, the ion conductivity of the ionic liquid crystals was up to 7 times increased with a maximum value of 2.0 x 10^-3 S cm^-1, and the derived dye-sensitized solar cell could operate stably at 70 °C with a 2-times enhancement and champion efficiency of 8.2%. The approach here was comparable but more processable to traditional methods via the macroscopical orientation of ionic liquid crystals for charge transport intensification within energy devices, which have great potential to develop high-performance solid-state electrolytes to achieve the best balance between efficiency and durability for energy devices. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Recommanded Product: 1632-83-3).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Yasukata, Tatsuro et al. published their research in Heterocycles in 2021 | CAS: 1632-83-3

Efficient synthesis of acrylates bearing an aryl or heteroaryl moiety: one-pot method from aromatics and heteroaromatics using formylation and the Horner-Wadsworth-Emmons reaction was written by Yasukata, Tatsuro;Matsuura, Takaharu. And the article was included in Heterocycles in 2021.HPLC of Formula: 1632-83-3 This article mentions the following:

Acrylates bearing an aryl or heteroaryl moiety were efficiently prepared by a one-pot process employing a sequence of lithiation, formylation and the Horner-Wadsworth-Emmons reaction starting from aromatic and heteroaromatic compounds The method was efficiently introduced an acrylate moiety into aromatic and heteroaromatic compounds In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3HPLC of Formula: 1632-83-3).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wang, Min et al. published their research in ChemistrySelect in 2022 | CAS: 1632-83-3

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Synthetic Route of C8H8N2

Microwave-Accelerated Cross-Dehydrogenative Coupling of Quinoxalin-2(1H)-ones with Alkanes under Transition-Metal-Free Conditions was written by Wang, Min;Zhang, Zhongyi;Xiong, Chunxia;Sun, Peipei;Zhou, Chao. And the article was included in ChemistrySelect in 2022.Synthetic Route of C8H8N2 This article mentions the following:

With simple alkanes as the alkyl radical precursors under microwave irradiation, a convenient and efficient cross-dehydrogenative alkylation reaction of quinoxalin-2(1H)-ones and other N-heteroarenes was achieved. The protocol demonstrates a broad substrate scope, good functional group tolerance, high atom economy and high efficiency, providing a wide range of valuable, structurally diverse C3 alkylated quinoxalin-2(1H)-ones and other alkylated N-heteroarenes in good-to-excellent yields. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Synthetic Route of C8H8N2).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Raja, Dineshkumar et al. published their research in Journal of Organic Chemistry in 2020 | CAS: 1632-83-3

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Electric Literature of C8H8N2

Metal-Free Synthesis of Benzimidazoles via Oxidative Cyclization of D-Glucose with o-Phenylenediamines in Water was written by Raja, Dineshkumar;Philips, Abigail;Palani, Pushbaraj;Lin, Wei-Yu;Devikala, Sundaramurthy;Senadi, Gopal Chandru. And the article was included in Journal of Organic Chemistry in 2020.Electric Literature of C8H8N2 This article mentions the following:

D-Glucose has been identified as an efficient C1 synthon in the synthesis of benzimidazoles from o-phenylenediamines via an oxidative cyclization strategy. Isotopic studies with ¹³C₆–D-glucose and D₂O unambiguously confirmed the source of methine. The notable features of this method include the following: broad functional group tolerance, a biorenewable methine source, excellent reaction yields, a short reaction time, water as an environmentally benign solvent, and the synthesis of vitamin B₁₂ component on the gram scale. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Electric Literature of C8H8N2).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Jelinkova, Kristyna et al. published their research in New Journal of Chemistry in 2020 | CAS: 1632-83-3

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Related Products of 1632-83-3

Binding study on 1-adamantylalkyl(benz)imidazolium salts to cyclodextrins and cucurbit[n]urils was written by Jelinkova, Kristyna;Kovacevic, Jelica;Wrzecionkova, Eva;Pruckova, Zdenka;Rouchal, Michal;Dastychova, Lenka;Vicha, Robert. And the article was included in New Journal of Chemistry in 2020.Related Products of 1632-83-3 This article mentions the following:

Multitopic guests are used as key components of mol. triggers, switchers, sensors, or reactors in recent supramol. chem. studies. The increasing complexity of these compounds correlates with the need for versatile, synthetically available binding motifs (building blocks) with tuneable supramol. properties. The utilization of a favored 1-adamantylmethyl moiety in ammonium, imidazolium and pyridinium salts is sometimes restricted by synthetic difficulties most likely related to the adamantane cage bulkiness. Therefore, we prepared a series of new adamantylated (benz)imidazolium salts with longer flexible linkers between the adamantane cage and cationic moiety. We tested the supramol. properties of these binding motifs towards the natural cyclodextrins α-CD, β-CD and γ-CD and cucurbit[n]urils (n = 7, 8) using NMR, mass spectrometry and titration calorimetry. All tested guests formed 1 : 1 complexes with the abovementioned hosts, retaining binding strengths, selectivity, and complex geometries in comparison to the parent methylene-linked homologues. We did not confirm our original concern that longer linkers would neg. affect the binding strength towards CBns due to the reduction in the ion-dipole interaction contribution. Therefore, we believe that adamantylalkyl imidazolium binding motifs can be used for multitopic supramol. guest construction. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Related Products of 1632-83-3).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

9/9/21 News Brief introduction of 1632-83-3

The synthetic route of 1632-83-3 has been constantly updated, and we look forward to future research findings.

1632-83-3, name is 1-Methylbenzimidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 1632-83-3

In an oven dried nitrogen purged 3 neck 100 mL round bottom flask, 1.00 g (7.57 mmol) of 1 -methylbenzimidazole in 20 mL of dry tetrahydrofuran is cooled to -78C. 10.69 mL (18.17 mmol) of 1.7 M t-butyllithium in hexanes is added and the reaction mixture is stirred at -780C. for 1 h. 2.55 g (11.36 mmol) of NIS in 20 mL of dry tetrahydrofuran is added. Reaction is removed from bath and stirred at room temperature for 1 hour, quenched with saturated aqueous solution of ammonium chloride, and diluted with dichloromethane. The layers are separated, the aqueous is extracted 3X100 mL dichloromethane, dried (MgSO4), and concentrated. The crude mixture is purified by EPO chromatography using hexanes:ethyl acetate as a solvent system. The product containing fractions are combined to obtain 0.400 g of the title compound, 21% yield. MS, ES+ = 259.0 (M+l); 1H NMR (DMSO-d6) 57.580-7.552 (m, 2H); 7.228-7.129 (m, 2H); 3.750 (s, 3H) ppm.

The synthetic route of 1632-83-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ELI LILLY AND COMPANY; WO2006/107784; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Discovery of 1632-83-3

The synthetic route of 1-Methylbenzimidazole has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 1632-83-3, name is 1-Methylbenzimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 1-Methylbenzimidazole

General procedure: 4.3 General procedure for CuO-catalyzed arylation and alkenylation of 1,3-azole (0012) Under argon, 0.5mmol of the bromobenzene or bromoalkene was added to the reaction mixture containing 0.25mmol of the benzoxazole, 0.5mmol K2CO3, 0.025mmol CuO, and 0.075mmol PPh3, followed by the addition of 2mL dry diglyme. The sealed reaction tube was stirred at 160C for 5-24h. After cooling, the reaction mixture was centrifuged to remove solid and separated the organic phase. Then, organic phase was extracted and dried over anhydrous MgSO4, and concentrated under reduced pressure after filtered. The residue was purified by column chromatography on silica gel eluted to afford corresponding product.

The synthetic route of 1-Methylbenzimidazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Wu; Tian, Yujie; Zhao, Na; Wang, Yuanyuan; Li, Jia; Wang, Zhenghua; Tetrahedron; vol. 70; 36; (2014); p. 6120 – 6126;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The important role of C8H8N2

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methylbenzimidazole, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 1632-83-3, name is 1-Methylbenzimidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1632-83-3, HPLC of Formula: C8H8N2

General procedure: To 1,4-dioxane were added azole derivative (0.293 M) and alpha-chloroacetamide derivative (0.267 M), which was prepared from chloroacetyl chloride and alpha-aminoester. After stirring the reaction mixture at 110 C for 16 h, the solvent was removed under reduced pressure. The residue was dissolved in methanol, and then activated carbon was added. After 16 h, the activated carbon was removed by filtration. The filtrate was concentrated under reduced pressure to obtain a solid, which was purified by reprecipitation using ethyl acetate and methanol to afford the corresponding azolium compound. Because of the highly hydroscopic character, elemental analyses of 1-4, 6-13, and 25 were not preformed. Azolium salts 7, 10, and 14-16 were reported in the preceding paper.12b Because of the light-sensitive character, elemental analyses of 28 and 29 were not preformed.

Reference:
Conference Paper; Yoshimura, Misato; Shibata, Naoatsu; Kawakami, Miaki; Sakaguchi, Satoshi; Tetrahedron; vol. 68; 17; (2012); p. 3512 – 3518;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The important role of C8H8N2

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

1-methylbenzimidazole (1 mmol, 132.1 mg)Perfluoroiodobutane (1.1 mmol, 380.5 mg) was placed in a 10 mL round bottom flask.Potassium tert-butoxide (1.2 mmol, 134.7 mg) is addedAnd 5mL of toluene,Stir at room temperature for 3 hours,TLC monitored the endpoint of the reaction.After the toluene was removed by rotary evaporation, the mixture was washed with water and extracted with dichloromethane. The organic phase was collected and dried. The dichloromethane was removed by rotary evaporation to give a crude product.The crude product was subjected to silica gel column chromatography with petroleum ether and ethyl acetate as eluents (ratio by volume = 15:1).2-Iodo-1-methylbenzimidazole was obtained (white solid, 208.9 mg, yield 81%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Liaoning University; Liang Fushun; Liu Xia; Han Zhengbo; Su Zhongmin; (10 pag.)CN107501023; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem