Category: 1632-83-3

Stop-Flow Microtubing Reactor-Assisted Visible Light-Induced Hydrogen-Evolution Cross Coupling of Heteroarenes with C(sp³)-H Bonds was written by Li, Dong-Sheng;Liu, Tao;Hong, Yang;Cao, Chen-Lin;Wu, Jie;Deng, Hong-Ping. And the article was included in ACS Catalysis in 2022.COA of Formula: C8H8N2 This article mentions the following:

Herein, assisted by stop-flow microtubing reactors, an operationally simple protocol for the visible light-induced hydrogen-evolution cross coupling of heteroarenes Ar-H (Ar = 4-methylquinolin-2-yl, phenanthridin-6-yl, 1,3-benzothiazol-2-yl, etc.) with unactivated C(sp³)-H bonds was developed in a metal- and external oxidant-free manner. A wide range of alkylated heteroarenes ArR¹ (R¹ = oxan-2-yl, Me, (1R,4S)-bicyclo[2.2.1]heptan-2-yl, etc.) was generated with common feedstock chems., including ethane. Mechanistic studies indicated that photoredox-induced hydrogen atom transfer processes followed by dehydrogenative rearomatization delivered the desired coupling products. The merits of this strategy were further demonstrated by the late-stage functionalization of various complex bioactive mols. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3COA of Formula: C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. COA of Formula: C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Tetracoordinate borates as catalysts for reductive formylation of amines with carbon dioxide was written by Jiang, Xiaolin;Huang, Zijun;Makha, Mohamed;Du, Chen-Xia;Zhao, Dongmei;Wang, Fang;Li, Yuehui. And the article was included in Green Chemistry in 2020.COA of Formula: C8H8N2 This article mentions the following:

We report sodium trihydroxyaryl borates as the first robust tetracoordinate organoboron catalysts for reductive functionalization of CO2. These catalysts, easily synthesized from condensing boronic acids with metal hydroxides, activate main group element-hydrogen (E-H) bonds efficiently. In contrast to BX3 type boranes, boronic acids and metal-BAr4 salts, under transition metal-free conditions, sodium trihydroxyaryl borates exhibit high reactivity of reductive N-formylation toward a variety of amines (106 examples), including those with functional groups such as ester, olefin, hydroxyl, cyano, nitro, halogen, MeS-, ether groups, etc. The over-performance to catalyze formylation of challenging pyridyl amines affords a promising alternative method to the use of traditional formylation reagents. Mechanistic investigation supports electrostatic interactions as the key for Si/B-H activation, enabling alkali metal borates as versatile catalysts for hydroborylation, hydrosilylation, and reductive formylation/methylation of CO2. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3COA of Formula: C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.COA of Formula: C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Quaternization of azido-N-heteroarenes with Meerwein reagent: A straightforward synthesis of 2-azido(benzo)imidazolium and related azido-N-heteroarenium tetrafluoroborates was written by Li, Yan;Wan, Ting-Biao;Guo, Bin;Qi, Xiao-Wen;Zhu, Chifan;Shen, Mei-Hua;Xu, Hua-Dong. And the article was included in Tetrahedron Letters in 2022.Category: imidazoles-derivatives This article mentions the following:

The 2-azido(benzo)imidazolium salts e.g., I have been made through quaternization of 2-Azido(benzo)imidazoles e.g., II with Meerwein reagent at ambient conditions. This one-pot protocol is also applicable to 4 or 3-azidopyridines e.g., III and appropriate azido(iso)quinolines e.g., IV to prepare correlative azido-N-heteroarenium salts e.g., I. When compared with their precursors, improved diazotransfer reactivity was observed for several representative azido-N-heteroarenium salts e.g., I in reaction with di-Et malonate. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Category: imidazoles-derivatives).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Manganese-Catalyzed Hydroborations with Broad Scope was written by Ghosh, Pradip;Jacobi von Wangelin, Axel. And the article was included in Angewandte Chemie, International Edition in 2021.Recommanded Product: 1-Methylbenzimidazole This article mentions the following:

Reductive transformations of easily available oxidized matter are at the heart of synthetic manipulation and chem. valorization. The applications of catalytic hydrofunctionalization benefit from the use of liquid reducing agents and operationally facile setups. Metal-catalyzed hydroborations provide a highly prolific platform for reductive valorizations of stable C:X electrophiles. Here, the authors report an especially facile, broad-scope reduction of various functions including carbonyls, carboxylates, pyridines, carbodiimides, and carbonates under very mild conditions with the inexpensive pre-catalyst Mn(hmds)₂. The reaction could be successfully applied to depolymerizations In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Recommanded Product: 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Recommanded Product: 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Facile access to N-formyl imide as an N-formylating agent for the direct synthesis of N-formamides, benzimidazoles and quinazolinones was written by Huang, Hsin-Yi;Lin, Xiu-Yi;Yen, Shih-Yao;Liang, Chien-Fu. And the article was included in Organic & Biomolecular Chemistry in 2020.Reference of 1632-83-3 This article mentions the following:

N-Formamides e.g., N-benzylformamide synthesis using N-formyl imide RC(O)NHC(O)H (R = Ph, tert-Bu, pyridin-4-yl, thiophen-2-yl, etc.) with primary and secondary amines e.g., benzylamine with catalytic amounts of p-toluenesulfonic acid monohydrate (TsOH路H₂O) is described. This reaction is performed in water without the use of surfactants. Moreover, N-formyl imide is efficiently synthesized using acylamidines RC(O)N=CHN(CH₃)₂ with TsOH路H₂O in water. In addition, N-formyl imide was successfully used as a carbonyl source in the synthesis of benzimidazole I (R¹ = H, Me; R² = H, Me, F, CN, etc.; R³ = H, Me, Cl; R⁴ = H, Me, Bn, Ts; R²R³ = -CH=CH-CH=CH-) and quinazolinone derivs II (R⁵ = H, Pr, Ph, cyclopentyl, etc.). Notable features of N-formylation of amines by using N-formyl imide include operational simplicity, oxidant- and metal-free conditions, structurally diverse products, and easy applicability to gram-scale operation. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Reference of 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Reference of 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Lewis acid / base-free strategy for the synthesis of 2-arylthio and selenyl benzothiazole / thiazole and imidazole was written by Balakishan, Guniganti;Kumaraswamy, Gullapalli;Narayanarao, Vykunthapu;Shankaraiah, Pagilla. And the article was included in Heterocyclic Communications in 2021.Related Products of 1632-83-3 This article mentions the following:

A Cu(II)-catalyzed Csp²-Se and Csp²-sulfur bond formation was achieved with moderate to good yields without the aid of Lewis acid and base. The reaction was compatible with a wide range of heterocycles such as benzothiazole, thiazole and imidazole. Also, this typical protocol was found to be active in thio-selenation via S-H activation. Addnl., a plausible mechanistic pathway involving Cu(III) putative intermediate was proposed. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Related Products of 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Related Products of 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazolyl Alanes – Synthesis, Structures and Reactivity Studies was written by Simon, Martin;Radius, Michael;Wagner, Hanna E.;Breher, Frank. And the article was included in European Journal of Inorganic Chemistry in 2020.Recommanded Product: 1-Methylbenzimidazole This article mentions the following:

Targeting the synthesis of Al/C based ambiphilic mols., the dehydrohalogenation of a series of (benz)imidazole alane adducts was investigated. Depending on the steric bulk of the heterocycle, different dimeric products with various ring sizes were obtained. Dehydrohalogenation of the adduct of 1-mesityl imidazole (^MesIm) and 0.5 [tBu₂AlBr]₂ furnished the dimer, featuring a “classical” N-heterocyclic carbene (NHC) and a mesoionic or “abnormal” NHC (aNHC) subunit within a single mol. The dimer is bound loosely enough to allow thermally induced isomerization of the dimer into the isomers dimer^NHC (all NHC) and dimer^aNHC (all aNHC). Dehydrohalogenation of the adduct of 1-mesityl-2-Me imidazole (^MesIm^Me) and 0.5 [tBu₂AlBr]₂ yielded a dimeric compound consisting of two N-heterocyclic olefin (NHO) subunits. Although these six- and eight-membered heterocycles show no FLP-type reactivity towards small mols. like H₂, CO or CO₂, an ambiphilic behavior of the imidazolyl alanes was observed Salt metathesis reactions using ^MesIm resulted in the formation of a compound which can be viewed as tBu₂AlBr adduct of an Al/N ambiphile. Utilizing heterocycles such as benzimidazole or spiroindole provided the entry point to C-H and N-H activation products, most likely resulting from a reactivity of intermediate species as Al/C ambiphiles. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Recommanded Product: 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ragi (finger millet) starch-based gel electrolytes for dye-sensitized solar cell application was written by Yogananda, K. C.;Ramasamy, Easwaramoorthi;Vasantha Kumar, S.;Rangappa, Dinesh. And the article was included in Bulletin of Materials Science in 2021.Application of 1632-83-3 This article mentions the following:

Starch was isolated from ragi grains using alkali extraction method. Crystallinity of isolated ragi starch (RGS) was studied using X-ray diffraction technique, and thermal properties of RGS were characterized by differential scanning calorimetry. Novel ragi starch (RGS) based gel electrolyte for dye-sensitized solar cells (DSSCs) was prepared and characterized for the first time. In the first part, the effects of additives guanidinium thiocyanate (GSCN) and N-methylbenzimidazole (NMBI) on the photovoltaic performance of DSSC were investigated. Considerable improvement of open circuit voltage was found in the addition of only NMBI to the electrolyte, while only addition of GSCN has an influence on the short circuit current. Synergetic effects were observed when NMBI and GSCN were used together in the gel electrolyte. In the second part, various weight percentages of multiwalled carbon nanotubes (MWCNTs) were added to observe the cell performance. DSSCs fabricated with the optimum weight percentage (1 wt%) of MWCNT achieved a maximum conversion efficiency of 4.34%, an open circuit voltage (V_oc) of 0.803 V, short circuit c.d. (J_sc) of 9.54 mA cm^-2 and fill factor (FF) of 56.59%. Here we reported the novel ragi starch-based gel electrolytes for DSSC application along with the effect of different additives, such as GSCN, NMBI, and various weight percentages of MWCNTs incorporated into the gel electrolyte. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Application of 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Application of 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

(Benz-)imidazolin-2-ylidene-benzimidazolatonickel(II) Chelates: Syntheses, Structures, and Tuning of Noninnocent Chelate Ligand Behavior was written by Kureja, Kunal;Bruhn, Clemens;Ringenberg, Mark R.;Siemeling, Ulrich. And the article was included in Inorganic Chemistry in 2019.Application In Synthesis of 1-Methylbenzimidazole This article mentions the following:

The deprotonation of 1-(1H-benzimidazol-2-yl)-3-methylbenzimidazolium hexafluorophosphate (2^MeH₂[PF₆]) and 1-(1H-benzimidazol-2-yl)-3-isopropylbenzimidazolium hexafluorophosphate (2^iPrH₂[PF₆]) with potassium tert-butoxide in THF afforded the benzimidazolium-benzimidazolates 2^MeH and 2^iPrH. The “instant carbene” behavior of these conjugated mesomeric betaines was demonstrated by trapping their carbenic tautomers 2‘^MeH and 2‘^iPrH with elemental sulfur and selenium, which afforded the corresponding thio- and selenourea derivatives 2‘^MeHE and 2‘^iPrHE (E = S, Se). The treatment of 2^MeH and 2^iPrH with nickelocene furnished the nickel(II) complexes [NiCp(2‘^Me)] and [NiCp(2‘^iPr)], which contain an anionic C,N_amido-chelating NHC ligand. The electronic structure and redox behavior of the nickel(II) chelates were investigated, as well as those of the closely related chelates [NiCp(1‘^Me)] and [NiCp(1‘^iPr)] derived from the corresponding imidazolium-benzimidazolates 1^MeH and 1^iPrH. According to DFT calculations, the HOMO is located over the NiCp moiety and the 蟺 system of the chelate ligand with a large contribution from the (benz-)imidazolate moiety. Cyclic voltammetry revealed a reversible oxidation to the monocation [NiCp(L)]⁺ (E_1/2 = 0.315, 0.222, 0.396, 0.265 V vs. ferrocene/ferrocenium for L = 1‘^Me, 1‘^iPr, 2‘^Me, 2‘^iPr, resp.) in CH₂Cl₂/0.1 M n-Bu₄N[B(Ar^F)₄] (B(Ar^F)₄^– = tetrakis(3,5-bis(trifluoromethyl)phenyl)borate), and isosbestic behavior was found in UV-vis-NIR spectroelectrochem. experiments The different redox potentials reflect the different donor/acceptor properties of the NHC part of the chelate ligands, with 1′^iPr being the strongest and 2‘^Me the weakest net electron donor. The EPR spectroscopic signature of [NiCp(2′^Me)]⁺ in CH₂Cl₂/0.1 M n-Bu₄N[B(Ar^F)₄] at 100 K is consistent with a chelate-ligand-based radical with strong spin-orbit coupling to the Ni center. In contrast, the EPR spectra of [NiCp(1‘^Me)]⁺, [NiCp(1‘^iPr)]⁺, and [NiCp(2‘^iPr)]⁺ indicate that these monocations are best described as Ni^III complexes, the comparatively higher contribution of the Ni^III(L) vs. the Ni^II(L^鈥?) valence tautomer being supported by the results of open-shell DFT calculations C,N_amido-nickel(II) chelates [NiCp(L)] containing (benz-)imidazolin-2-ylidene-benzimidazolate ligands (L) are reversibly oxidized to [NiCp(L)]⁺. The [NiCp(L)] HOMO and [NiCp(L)]⁺ SOMO are delocalized over the NiCp unit and the (benz-)imidazolate moiety of L. The chelate ligand L can support the unusual oxidation state Ni^III. Its noninnocent behavior may be tuned by the N substituent and the backbone of its NHC part, the carbene’s substitution pattern thus determining the relative contribution of the Ni^III(L) vs. the Ni^II(L^鈥?) valence tautomer of [NiCp(L)]⁺. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Application In Synthesis of 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Application In Synthesis of 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The Performance-Determining Role of Lewis Bases in Dye-Sensitized Solar Cells Employing Copper-Bisphenanthroline Redox Mediators was written by Fuerer, Sebastian O.;Milhuisen, Rebecca A.;Kashif, Muhammad K.;Raga, Sonia R.;Acharya, Shravan S.;Forsyth, Craig;Liu, Maning;Frazer, Laszlo;Duffy, Noel W.;Ohlin, C. Andre;Funston, Alison M.;Tachibana, Yasuhiro;Bach, Udo. And the article was included in Advanced Energy Materials in 2020.Application In Synthesis of 1-Methylbenzimidazole This article mentions the following:

Copper redox mediators have enabled open-circuit voltages (VOC) of over 1.0 V in dye-sensitized solar cells (DSCs) and have helped to establish DSCs as the most promising solar cell technol. in low-light conditions. The addition of additives such as 4-tert-butylpyridine (tBP) to these electrolytes has helped in achieving high solar cell performances. However, emerging evidence suggests that tBP coordinates to the Cu(II) species and limits the performance of these electrolytes. To date, the implications of this coordination are poorly understood. Here, the importance of Lewis base additives for the successful implementation of copper complexes as redox mediators in DSCs is demonstrated. Two redox couples, [Cu(dmp)₂]^+/2+ and [Cu(dpp)₂]^+/2+ (with dmp = 2,9-dimethyl-1,10-phenanthroline and dpp = 2,9-diphenyl-1,10-phenanthroline) in combination with three different Lewis bases, TFMP (4-(trifluoromethyl)pyridine), tBP, and NMBI (1-methyl-benzimidazole), are considered. Through single-crystal X-ray diffraction anal., absorption, and ¹H-NMR spectroscopies, the coordination of Lewis bases to the Cu(II) centers are studied. This coordination efficiently suppresses recombination losses and is crucial for high performing solar cells. If, however, the coordination involves a ligand exchange, as is the case for [Cu(dpp)₂]^+/2+, the redox mediator regeneration at the counter electrode is significantly retarded and the solar cells show current limitations. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Application In Synthesis of 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application In Synthesis of 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem