Category: 16265-04-6

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16265-04-6, name is 2-Chloro-1H-imidazole, A new synthetic method of this compound is introduced below., SDS of cas: 16265-04-6

Reference example 10 Preparation of 2-chloro-4,5-diiodoimidazole 2-Chloroimidazole (5.13 g) was suspended in water (150 ml), and an aqueous solution of 6N sodium hydroxide (17 ml) was added. Next, iodine (25.9 g) was added and was stirred at a room temperature for 3 hours. After that, the reaction mixture was treated with an aqueous solution of sodium sulfite, the deposited matters were collected by filtration and dried, there was obtained 2-chloro-4,5-diiodoimidazole (16.4 g, yield: 92.5%) as yellow solid. 1H-NMR (DMSO-d6) delta(ppm): 13.61 (1H, bs) 13C-NMR (DMSO-d6) delta (ppm): 133.07.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Otsuka Pharmaceutical Company, Limited; EP1553088; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16265-04-6, name is 2-Chloro-1H-imidazole, A new synthetic method of this compound is introduced below., Quality Control of 2-Chloro-1H-imidazole

A reaction vessel A’-1 (1.74g, 17.0mmol), A’-2 (2.07g, 17.0mmol), Tetrakis (triphenylphosphine) palladium (0.7g, 1.08mmol), Potassium carbonate (5.3 g, 38.3mmol), toluene (60 mL), ethanol (20 mL) and distilled water (20 mL) were added, followed by stirring at 60 C for 3 hours.After the reaction was completed, the reaction mixture was cooled to room temperature, extracted with ethyl acetate, dried over MgSO 4, and then the organic solvent was removed, and A-1 (1.67 g, 68%) was obtained by silica column method

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Choi Don-su; Choi Jin-sol; (70 pag.)KR2019/35043; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Some common heterocyclic compound, 16265-04-6, name is 2-Chloro-1H-imidazole, molecular formula is C3H3ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 2-Chloro-1H-imidazole

B’-1 (2.05g, 20.0 mmol), B’-2 (3.38 g, 20.0mmol), Pd2(dba)3 (0.18g, 0.2mmol), PtBu3 (0.04g, 0.4mmol) and KOtBu (1.44g , 15.0 mmol) were dissolved in 40 ml of toluene, and the mixture was stirred at 80 C for 4 hours. The reaction mixture was cooled to room temperature, and extracted three times with 50 mL of water and 30 mL of diethyl ether. The combined organic layer was dried over MgSO4 and the solvent was evaporated. The resulting residue was purified by silica column method to obtain Intermediate B-1 (3.86 g, yield 82%)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 16265-04-6, its application will become more common.

Reference:
Patent; Choi Don-su; Choi Jin-sol; (70 pag.)KR2019/35043; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

16265-04-6, name is 2-Chloro-1H-imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 16265-04-6

4 g of 98% sulfuric acid, 2.04 g of 2-chloroimidazole ((? 02 mol) was added to the three-necked flask, and the mixture was stirred at room temperature (? 5h,And then heated to 45 ~ 55 C, slowly dropping from 1. 9g95% fuming nitric acid (0. 03mol) and 5g 20% fuming sulfuric acid composition of the mixed acid, after dropping, the temperature to 110 C reaction lh, the end After the reaction solution was poured into ice water, the pH was adjusted to 3 to 4 with aqueous ammonia, filtered and the cake was dried to give a white powdery solid 2-chloro-4-nitroimidazole, 56 mg, yield 87.3% HPLC purity 99. 4%, melting point 218. 6 ~ 219.5 C.

The synthetic route of 16265-04-6 has been constantly updated, and we look forward to future research findings.

Related Products of 16265-04-6,Some common heterocyclic compound, 16265-04-6, name is 2-Chloro-1H-imidazole, molecular formula is C3H3ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To make PCA 1 4-(2-(dimethylamino)ethoxy)-5-methoxy-2-nitrobenzyl 2-chloro-1H-imidazole-1-carboxylate, carbonyldichloroimidazole (CDCl) was freshly prepared by dissolving 2-chloroimidazole (102 mg, 1.0 mmol) in THF (1.5 mL) and triphosgene (25 mg, 0.08 mmol) dissolved in THF (1.0 mL) was added to this. The resulting mixture was stirred for 30 min at room temperature and then filtered. The filtrate was concentrated in vacuo and dried under high vacuum for 5 min resulting in a white powder (1H NMR (300 MHz, DMSO-d6) delta7.70 (d, J=1.9 Hz, 2H), 7.14 (d, J=1.9 Hz, 2H)), which was immediately used without any further purification. The white powder was dissolved in THF (1.0 mL) and to this was added a solution of compound 4a (8 mg, 0.03 mmol) dissolved in THF (1.0 mL) and the resulting mixture was stirred for 5 min at room temperature. Next, DIPEA (35 muL, 0.20 mmol) was added and the reaction was stirred for an additional 5 min before concentrating in vacuo. The obtained yellow solid was immediately dissolved in DMSO (30 muL) resulting in a -1 M solution and stored at -80 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-1H-imidazole, its application will become more common.

Reference:
Patent; The Board of Trustees of the Leland Stanford Junior University; Velema, Willem Arend; Kool, Eric T.; (79 pag.)US2019/264205; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16265-04-6, name is 2-Chloro-1H-imidazole, A new synthetic method of this compound is introduced below., Quality Control of 2-Chloro-1H-imidazole

Reference example 10 Preparation of 2-chloro-4,5-diiodoimidazole 2-Chloroimidazole (5.13 g) was suspended in water (150 ml), and an aqueous solution of 6N sodium hydroxide (17 ml) was added. Next, iodine (25.9 g) was added and was stirred at a room temperature for 3 hours. After that, the reaction mixture was treated with an aqueous solution of sodium sulfite, the deposited matters were collected by filtration and dried, there was obtained 2-chloro-4,5-diiodoimidazole (16.4 g, yield: 92.5%) as yellow solid. 1H-NMR (DMSO-d6) delta(ppm): 13.61 (1H, bs) 13C-NMR (DMSO-d6) delta (ppm): 133.07.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Otsuka Pharmaceutical Company, Limited; EP1553088; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

These common heterocyclic compound, 16265-04-6, name is 2-Chloro-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C3H3ClN2

To a solution of 2-chloro-1H-imidazole (250 mg, 2.44 mmol) in DMF (5 mL) were added K2CO3 (1011 mg, 7.32 mmol) and tert-butyl (2-bromoethyl)carbamate (601 mg, 2.68 mmol), and the resulting mixture was stirred at 80 C. for 16 h then concentrated under reduced pressure. H2O (20 mL) was added, the mixture was extracted with EtOAc (3*10 mL), and the combined organic layers were washed with sat. aq. NaCl, dried over MgSO4, filtered and concentrated under reduced pressure. The residue was purified by SiO2 gel chromatography (0% to 5% MeOH in CH2Cl2) to give the title compound as a white solid (394 mg, 66%). MS (ES+) C10H16ClN3O2 requires: 245, found: 246 [M+H]+.

The synthetic route of 2-Chloro-1H-imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Board of Regents, The University of Texas System; LE, Kang; SOTH, Michael J.; JONES, Philip; CROSS, Jason Bryant; CARROLL, Christopher L.; MCAFOOS, Timothy Joseph; MANDAL, Pijus Kumar; US2019/298729; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16265-04-6, name is 2-Chloro-1H-imidazole, A new synthetic method of this compound is introduced below., Recommanded Product: 2-Chloro-1H-imidazole

4 g of 98percent sulfuric acid, 2.04 g of 2-chloroimidazole ((? 02 mol) was added to the three-necked flask, and the mixture was stirred at room temperature (? 5h,And then heated to 45 ~ 55 ¡ã C, slowly dropping from 1. 9g95percent fuming nitric acid (0. 03mol) and 5g 20percent fuming sulfuric acid composition of the mixed acid, after dropping, the temperature to 110 ¡ã C reaction lh, the end After the reaction solution was poured into ice water, the pH was adjusted to 3 to 4 with aqueous ammonia, filtered and the cake was dried to give a white powdery solid 2-chloro-4-nitroimidazole, 56 mg, yield 87.3percent HPLC purity 99. 4percent, melting point 218. 6 ~ 219.5 ¡ã C.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Yancheng Institute Of Technology; Zhao, LingLing; Dai, Yong; Qi, gang; (5 pag.)CN103396369; (2016); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 16265-04-6, name is 2-Chloro-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16265-04-6, HPLC of Formula: C3H3ClN2

Intermediate 77 Sodium hydride (60%> in mineral oils, 468 mg, 11.7 mmol) was added to 2-chloro-lH- imidazole (800 mg, 7.8 mmol) in THF (24 mL) at 0 C. The mixture was stirred at rt for 10 min. Then 2-(trimethylsilyl)ethoxymethyl chloride (2 mL, 11.7 mmol) was added at 0 C and the mixture was stirred for 2 h. The mixture was diluted with sat. sol. NH4C1 and extracted with EtOAc. The organic layer was separated, dried (MgS04), filtered and the solvents evaporated in vacuo. The crude product was purified by flash column chromatography (silica; EtOAc in Heptane 0/100 to 50/50). The desired fractions were collected and the solvents concentrated in vacuo to yield 1-77 (1.52 g, 89%).

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Reference:
Patent; JANSSEN PHARMACEUTICA NV; VAN GOOL, Michiel, Luc, Maria; ALCAZAR-VACA, Manuel, Jesus; ALONSO-DE DIEGO, Sergio-Alvar; DE LUCAS OLIVARES, Ana, Isabel; (105 pag.)WO2016/87487; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16265-04-6, name is 2-Chloro-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C3H3ClN2

Zinc nitrate hexahydrate (120 mg, 0.4 mmol) and 2-cim (108 mg, 1 mmol) were added to methanol (4 mL) in a glass vial. The mixture was homogenized by sonication for 2 mins. Then the vial was capped and placed into 100 C. oven for two days. Colorless polyhedral crystals of Compound 1 (See FIG. 4) were obtained (42 mg). Similarly, crystals of Compound 2 (55 mg) were obtained (See FIG. 5) by reacting zinc nitrate hexahydrate (121 mg, 0.4 mmol) and 2-bim (120 mg, 0.8 mmol) in ethanol (95%, 4 mL) for 2 days

The synthetic route of 16265-04-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; US2011/282067; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem